Navigation Links
Common erectile dysfunction drug not helpful for heart failure patients, study finds
Date:3/11/2013

SAN FRANCISCO -- A commonly used erectile dysfunction drug, sildenafil, doesn't help patients who have heart failure with preserved ejection fraction, a condition in which the heart's lower chambers are stiff and cannot relax and fill fully between beats. That is the finding of the RELAX study, presented today at the American College of Cardiology's 62nd Annual Scientific Session and simultaneously published in The Journal of the American Medical Association. The study's lead author called the results disappointing.

Sildenafil, a phosphodiesterase-5 inhibitor, had shown encouraging results in smaller studies and in animal models.

In this study, researchers looked at the drug's effect on maximum exercise ability as assessed by peak oxygen consumption and on how far people could walk in six minutes, their clinical status and their heart structure and function. They found no benefit, says lead author Margaret Redfield, M.D., heart failure specialist and researcher at Mayo Clinic in Rochester, Minn.

"It was surprising and a disappointment, and it was contradictory to our hypothesis," says

Dr. Redfield. "There are few options for help for these patients, and we hoped we would find something."

When the heart does not pump blood well, heart failure symptoms such as shortness of breath, fatigue and weakness can result.

The RELAX study is the first multicenter trial to look at the effect of therapy with sildenafil on this condition, also known as diastolic heart failure. The study was a double-blinded, placebo-controlled, randomized trial of 216 stable outpatients with heart failure (with an ejection fraction of greater than 50 percent) with reduced exercise capacity; the median age was 69. Participants were enrolled during a 3.5-year period from the nine U.S. centers including Mayo Clinic that make up the Heart Failure Clinical Research Network and 17 other centers in the United States and Canada.

"This was a very complex study and criteria for study participants were very strict," Dr. Redfield says. "But it's most likely that we didn't see the results we hoped for because this type of heart failure just does not respond to this drug."


'/>"/>

Contact: Traci Klein
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Related medicine news :

1. Common MS drugs taken together do not reduce relapse risk
2. Study: HPV Genital Warts is Most Common Sexually Transmitted Infection in U.S. Military, polyDNA Recommends Gene-Eden-VIR Against the HPV Infection
3. Anxiety May Be More Common Than Depression After Pregnancy
4. 7 genetic risk factors found to be associated with common eye disorder
5. Stress Disorder May Be Common Among ICU Patients on Ventilators
6. Study identifies growth factor essential to the most common malignant pediatric brain tumor
7. How common is sexting among urban minority youth?
8. PTSD symptoms common among ICU survivors
9. Common Sense Approaches May Stem ICU Delirium
10. Plastics Chemical BPA Common in Preemie ICU: Study
11. UCLA study finds endocrine disorder is most common cause of elevated calcium levels
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/2/2016)... ... May 02, 2016 , ... Advanced Spine ... fluid/“stem cells” and Platelet Rich Plasma (PRP) injections. “These are becoming the ‘go-to’ ... Baranski, D.C., of Advanced Spine & Sport Medical. “We are very excited to ...
(Date:5/1/2016)... ... May 01, 2016 , ... Women's Excellence in Wellness, powered ... taught by Patti Dolan, a Young Living Gold Member. , The class will be ... followed by a small intro to the Oils that can benefit participant's yoga practice, ...
(Date:5/1/2016)... ... 2016 , ... ProBrand Reveal Volume 2 is a set of versatile and smooth logo reveals ... animations, users can easily create a unique logo reveal in just a matter of minutes. ... Use these title presets to add a uniquely animated logo to any photos or videos. ...
(Date:5/1/2016)... ... May 01, 2016 , ... Good Circle Insurance Agency ... of chiropractic help. The agency offers a verity of health, life and injury policies ... to Chris Nelson at the firm, “Many insurance plans don’t cover chiropractic care, so ...
(Date:4/30/2016)... ... April 30, 2016 , ... Create an abstract shape animation ... and manipulate three-dimensional shapes with ease all within Apple Motion . Users ... polygon texture animation, opacity texture animation, overall shape texture displacement, twist, camera controls, ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... 28, 2016   Acsis , a leading provider ... IT market research and advisory firm IDC has named ... MarketScape: Worldwide Pharmaceutical Track and Trace Software 2016 Vendor ... an assessment of the capabilities and business strategies of ... market. Logo - http://photos.prnewswire.com/prnh/20160427/360791LOGO ...
(Date:4/27/2016)... Inc. (Nasdaq: HOLX ) announced today ... quarter ended March 26, 2016.  GAAP diluted earnings ... non-GAAP diluted EPS of $0.47 increased 14.6%.  Revenue ... basis, and 6.3% on a constant currency basis.  ... highlighted by 14.6% growth in non-GAAP EPS," said ...
(Date:4/27/2016)... , April 27, 2016 ... accelerator (MR-linac) platform will be the focal point of ... of the European Society for Radiotherapy & Oncology, taking ... MR-linac integrates a state-of-the-art radiotherapy system and a high-field ... to clearly see the patient,s anatomy in real time. ...
Breaking Medicine Technology: