Navigation Links
Common epilepsy drug could prevent and treat Alzheimer's disease
Date:10/27/2008

The team led by UBC Psychiatry Prof. Weihong Song, who is also the Jack Brown and Family Professor and Chair in Alzheimer's Disease at UBC, found that if Valproic Acid (VPA) is used as a treatment in early stages of AD memory deficit is reversed.

The study, published in the Journal of Experimental Medicine, reveals that VPA works by inhibiting the activity of an enzyme that produces a neurotoxic protein called beta Amyloid. In doing so, plaque formation is discontinued. Amyloid beta-proteins are the central component of neurotoxic plaques in AD.

"We found that if we used VPA in the early stage of Alzheimer's disease, in model mice, it reduced plaque formation and further prevented brain cell death and axon damage," says Song, who is a Canada Research Chair in Alzheimer's disease and Director of the Townsend Family Laboratories in UBC's Faculty of Medicine. "The drug also improved performance in memory tests."

The results will help inform the design of human clinical trials because researchers now understand the mechanisms and pathology of VPA in AD animal models.

"We are very excited about these results because we now know when VPA should be administered to be most effective and we now know how VPA is working to prevent AD," says Song, who is also a member of the Brain Research Centre at UBC and VCHRI. "A small human clinical trial is currently underway and we expect results to be available in the next year."

AD is a neurodegenerative disorder characterized by progressive cognitive deterioration and is the most common form of dementia. The Alzheimer Society of Canada estimates that AD affects close to 300,000 Canadians and accounts for two-thirds of all cases of dementia. By 2031, about 750,000 Canadians will suffer from AD and related dementias.


'/>"/>

Contact: Catherine Loiacono
catherine.loiacono@ubc.ca
604-822-2644
University of British Columbia
Source:Eurekalert

Page: 1

Related medicine news :

1. Westaim to deregister its common stock in the United States
2. Vision loss more common in people with diabetes
3. deCODE Launches deCODE BreastCancer(TM), a Genetic Test to Screen for Risk of the Common Forms of Breast Cancer
4. LegalView Informs Patients of Possible Cimzia Cancer Link, Drug Commonly Used to Treat Arthritis
5. National study finds post-traumatic stress disorder common among injured patients
6. Common painkillers lower levels of prostate cancer biomarker
7. Survey: Tanorexia common among university students
8. Depression common among Rwandan youth who head households
9. Commonwealth Medical Group Physicians to Join Aurora Health Care
10. Longs Drug Stores Corporation Declares Cash Dividend on Common Shares
11. Enhanced Care Initiatives (HC Innovations, Inc.) Contracts with HIP and GHI to Create a Medical Home Network Project with Support from the Commonwealth Fund
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/23/2017)... NJ (PRWEB) , ... February 23, 2017 , ... ... in thought leadership , media relations, content marketing, social media management, corporate ... several clients already in the state and in nearby New Hampshire, Massachusetts and ...
(Date:2/23/2017)... ... February 23, 2017 , ... On April 13, ... symposium on “Doping in Sport: How the Culture Might Change,” in ... LLP. The symposium will be held at Pepperdine University in Malibu, California. , ...
(Date:2/23/2017)... ... February 23, 2017 , ... ... interactive publication where generations converge and explore the world from different perspectives. By ... Magazine enables readers to gain understanding, increase empathy, and find greater happiness. ...
(Date:2/23/2017)... ... February 23, 2017 , ... ... today that it will soon begin franchising throughout the U.S. starting this spring. ... help bring the practice of meditation mainstream. Current Meditation will be the first ...
(Date:2/23/2017)... ... February 23, 2017 , ... ... partnership with the Rhode Island Consortium for Autism Research and Treatment (RI-CART) and ... children with autism spectrum disorder (ASD) to see films in an environment that ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... , Feb. 23, 2017  This report analyzes ... by the following Products: Intermediates, Analytical, ... the report include Pharmaceuticals, and Agrochemicals. The report provides ... , Europe , and Rest ... the period 2015 through 2022. Also, a six-year historic ...
(Date:2/24/2017)... , Feb 24, 2017 Medivir ... proposal for a new Board of Directors that will ... 2016-2017 Nomination Committee comprises representatives of the company,s three ... of 2016 who have accepted a seat on the ... composition of the 2016-2017 Nomination Committee was as follows:  ...
(Date:2/23/2017)... 2017 Visiomed, the French leader in ... is changing the landscape of healthcare with their ... pro-active, custom-made solutions. Recognizing the rising demand of ... healthcare without walls, Visiomed has launched BewellConnect, the ... healthcare professionals that is empowering the lives of ...
Breaking Medicine Technology: