Navigation Links
Common diabetes drug may 'revolutionize' cancer therapies
Date:6/3/2009

This release is available in French.

Researchers at McGill University and the University of Pennsylvania have discovered that a widely used anti-diabetic drug can boost the immune system and increase the potency of vaccines and cancer treatments. Their findings will be published June 3 in the journal Nature.

The discovery was made by Dr. Russell Jones, an assistant professor at McGill's Goodman Cancer Centre and the Department of Physiology, Faculty of Medicine, Yongwon Choi, PhD, professor of pathology and laboratory medicine, and postdoctoral fellow Erika Pearce, PhD, of the University of Pennsylvania. They discovered that the widely prescribed diabetes treatment metformin increases the efficiency of the immune system's T-cells, which in turn makes cancer and virus-fighting vaccines more effective.

The specialized white blood cells of the human immune system known as "T-cells" remember pathogens they have encountered from previous infections or vaccinations, enabling them to fight subsequent infections much faster. This "immunological memory" has been the subject of intense study for many years, but until now the underlying cellular mechanisms behind it were not well understood. Now, the researchers say, they can use diabetic therapies to manipulate T-cell response and enhance the immune system's response to infections and cancer alike.

"Many genes involved in diabetes regulation also play a role in cancer progression," Jones explained. "There is also a significant body of data suggesting that diabetics are more prone to certain cancers. However, our study is the first to suggest that by targeting the same metabolic pathways that play a role in diabetes, you can alter how well your immune system functions."

"We serendipitously discovered that the metabolizing, or burning, of fatty acids by T-cells following the
'/>"/>

Contact: Cynthia Lee
cynthia.lee@mcgill.ca
514-398-6754
McGill University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. HealthEdge(R) and Click4Care(R) Announce Common Leadership
2. Most common brain cancer may start in neural stem cells
3. Most common brain cancer may originate in neural stem cells
4. Bioniche Represented at House of Commons Sub-Committee on Food Safety
5. Common migraine pain condition also prevalent in cluster headache
6. WeissComm Group Acquires Common Sense Media Group, Appoints Founder Bob Pearson Chief Technology and Media Officer to Help Clients Evaluate and Optimize Social Media
7. Cogdell Spencer Announces Commencement of Common Stock Offering
8. Medivation Announces Offering of 2,750,000 Shares of Common Stock
9. Americans United for Life: Obama Nominates Avowed Judicial Activist Judge Who Undermines Common Ground
10. PET scan can non invasively measure early assessment of treatment for common type of breast cancer
11. Among Obese Diabetics, Sleep Apnea May Be Common
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/12/2014)... (PRWEB) July 12, 2014 Wright & Schulte ... clients in Just For Men Lawsuits (case #59776/2014), announces ... consumers of reports that allege the popular hair dye, Just ... burns to their face, neck and other areas. In addition ... For Men chemical burns , the advertisements being run by ...
(Date:7/12/2014)... 12, 2014 Maxim Peptide, a website ... are used solely in scientific experiments, is currently celebrating ... in business, Maxim Peptide, which was created by the ... new and updated website that now features a special ... been updated with fascinating articles about peptide research, including ...
(Date:7/11/2014)... Recently, MagicQuinceaneraDresses.com, the popular online supplier of special occasion ... Quinceanera dresses . The company’s new items are specially ... paying a large amount of money. They are all ... The company’s online shop has become a one stop ... In addition to exquisite Quinceanera dresses, it also offers ...
(Date:7/11/2014)... According to new report "C4ISR Market (2014 ... register a CAGR of 2.28% to reach $93.04 ... tables and 76 figures spread through 185 pages ... , Early buyers will receive 10% customization ... report provides market analysis of the global C4ISR ...
(Date:7/11/2014)... PA (PRWEB) July 11, 2014 Butler Mobility ... of Inclined Platform Lifts . Previously the two ... offering five new beautiful earth tone colors as standard colors ... blend well in the home but will enhance the beauty ... choice for any home color scheme or individual décor. , ...
Breaking Medicine News(10 mins):Health News:Just for Men Lawsuit News: TV Campaign Launched by Wright & Schulte LLC to Inform Consumers of the Alleged Association between the Popular Hair Dye and Chemical Burns 2Health News:Just for Men Lawsuit News: TV Campaign Launched by Wright & Schulte LLC to Inform Consumers of the Alleged Association between the Popular Hair Dye and Chemical Burns 3Health News:Just for Men Lawsuit News: TV Campaign Launched by Wright & Schulte LLC to Inform Consumers of the Alleged Association between the Popular Hair Dye and Chemical Burns 4Health News:Maxim Peptide Celebrates Second Anniversary Online with an Updated Website and Special Deals Section 2Health News:Cheap Quinceanera Dresses Now Available At MagicQuinceaneraDresses.com 2Health News:C4ISR Market Estimated to Reach $93.04 Billion by 2019 - New Report by MarketsandMarkets 2Health News:C4ISR Market Estimated to Reach $93.04 Billion by 2019 - New Report by MarketsandMarkets 3Health News:C4ISR Market Estimated to Reach $93.04 Billion by 2019 - New Report by MarketsandMarkets 4Health News:Butler Mobility Products Announces Five New Standard Colors for Their Inclined Platform Lifts 2
... -- The risk of fractures after weight-loss surgery may be ... Prior research has shown that people who undergo surgery to ... for bone fractures. One study, for example, showed a 1.8-fold ... But further analysis showed the risk was actually closer to ...
... thought to accelerate tumor growth in thyroid cancer patients ... for novel cancer therapies, a Mayo Clinic study has ... Clinic researcher Honey Reddi, Ph.D., at the Endocrine Society ... widespread implications in cancer research and endocrinology . ...
... womb can program the potential for adverse health effects in ... on whether the mother or father transmits them, a new ... The Endocrine Society,s 93rd Annual Meeting in Boston. "This ... the womb to excessive levels of stress hormones, known as ...
... 2011 - Additional radiation treatment improves disease free survival ... early breast cancer who have had breast conserving surgery ... results will be presented Monday, June 6 at the ... "These results are potentially practice-changing," said Dr. ...
... -- Medical students who are physically fit are more likely ... new study. Researchers found that medical students who ... physical activity guidelines often felt strongly that being active themselves ... treating. In analyzing certain markers of physical health -- ...
... News) -- College athletes who suffer a concussion may ... concussion is a head injury that can cause headache, ... hearing, as well as difficulty following instructions. "This ... in student-athletes," study author Robert Gardner, a student ...
Cached Medicine News:Health News:Weight-Loss Surgery Linked to Rise in Fracture Risk 2Health News:Fighting cancer with cancer: Mayo Clinic finds promising use for thyroid cancer gene 2Health News:Fetal programming of disease risk to next generation depends on parental gender 2Health News:Breast cancer surgery patients benefit from adding radiation therapy 2Health News:Fit Doctors More Likely to Prescribe Exercise: Study 2Health News:Concussions Tied to Verbal Memory Loss in Young Athletes 2
(Date:7/11/2014)...  Kindred Hospital Houston Northwest, with Wound Care ... its new outpatient wound healing center.  The wound ... chronic, hard to heal wounds. Chronic wounds include ... lower leg wounds related to blood flow issues, ... injury wounds which are complex and demonstrate delayed ...
(Date:7/11/2014)... 2014  Veran Medical Technologies, a U.S. ... positive, cost-effective final results for the initial ... SPiNPerc endobronchial percutaneous biopsy study results support ... biopsy when a traditional bronchoscopic method is ... positive financial outcomes when more can be ...
(Date:7/10/2014)... July 10, 2014  The U.S. Department of Health ... to University Hospitals (UH) Case Medical Center Seidman Cancer ... model aimed at improving care for patients with complex ... project will test a unique model developed at UH ... disease, significant comorbidities, or demonstrated need for high health ...
Breaking Medicine Technology:Kindred Hospital Houston Northwest, With Wound Care Specialists, Opens Outpatient Wound Healing And Hyperbaric Center 2Veran Medical Publishes Lung Cancer Patient Management Study 2University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 2University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 3University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 4
... 11, 2011 Reportlinker.com announces that ... available in its catalogue: ... New pricing rules set to negatively ... internationally http://www.reportlinker.com/p0360217/Germany-Pharmaceutical-Market-Overview-–-New-pricing-rules-set-to-negatively-impact-drug-sales-both-domestically-and-internationally.html ...
... 11, 2011 Reportlinker.com announces that a new ... The Endoscopy Device Market Outlook ... Introduction This endoscopy device market ... global market, covering endoscopic accessories, instruments, endoscopes, and ...
Cached Medicine Technology:Reportlinker Adds Germany Pharmaceutical Market Overview - New pricing rules set to negatively impact drug sales both domestically and internationally 2Reportlinker Adds The Endoscopy Device Market Outlook to 2015 2
Bayonet Kerrison Rongeur, ceramic ejector, 9.5 length 40 Fwd, 6.5 working length 165 mm....
Hardy Micro Dissector, bayonet. Working distance 4 1/4" (120 mm). Angled up, tip width: 2 mm....
Papavero-caspar specula for trans-sphenoidal hypophysectomy....
Fahlbusch hypophysectomie instrument, spoon, bayonet-shaped, malleable....
Medicine Products: