Navigation Links
Common class of pain drugs reduces severity of postpartum breast cancers
Date:8/11/2011

Published online on Aug. 7, 2011, the journal Nature Medicine reports that non-steroidal anti-inflammatory drugs including ibuprofen reduce the severity of postpartum breast cancers in animal models. "We caution patients and providers that because a mother's body is undergoing radical changes during this time, we can't yet speak to the safety of these drugs for women diagnosed with or at risk for postpartum breast cancer, and thus can't yet recommend NSAIDs as a preventative therapy or cancer treatment," says Pepper Schedin, PhD, investigator at the University of Colorado Cancer Center and professor in the division of medical oncology at the University of Colorado School of Medicine, who teamed up on this study with Virginia Borges, MD, an expert in young women's breast cancer who is also at the Cancer Center. First authors of this important paper are University of Colorado trainees, Drs. Traci Lyons and Jenean O'Brien.

The story starts with breast involution the process by which milk-producing cells that are no longer needed are killed and replaced with fat cells. During this time of change, the breast is especially susceptible to the development of cancer. In fact, recent studies show that women who have children before age 30 increase their risk of pre-menopausal breast cancer by 10% and women who wait to have children until after age 35 increase their risk by 30%. Not only is breast cancer more prevalent in young mothers than women who have not had a child, but cancers diagnosed in the early years postpartum tend to be more aggressive, with increased risk of spreading to other organs. For example, one study reported that women diagnosed with cancer within two years of giving birth had a 40% five-year survival rate, as opposed to a 70% five-year survival rate for women diagnosed outside the postpartum window.

What this University of Colorado research team discovered is that breast involution shares similarities with wounds, and wounds can cause cells to become cancerous in addition to promoting metastasis of otherwise localized tumor cells. Two wound-like changes that occur in the postpartum breast are an increase in fibrous collagen (the protein that gives our flesh structure) and increase of an enzyme called COX-2.

In addition to causing inflammation and pain, COX-2 aids the formation of fibrous collagen, which in the process of wound healing serves as a highway along which healthy skin cells travel in order to close the wound. However, this collagen also forms a rich architecture for the growth and spread of cancers. In short, breast involution leads to COX-2, which leads to fibrous collagen, which promotes the release of more COX-2, and this positive feedback loop can help a tumor grow and push into other tissues.

It's a vicious chain, but one with a weak link: many drugs exist that inhibit COX-2. These include the non-steroidal anti-inflammatories (NSAIDs), such as ibuprofen, or celecoxib, which is a more targeted COX-2 inhibitor used in other inflammatory diseases like arthritis. "Inhibition of COX-2 slows the formation of fibrillar collagen and thus both tumor growth and the tumor's travel into the lung," write Schedin and collaborators. Sure enough, Schedin and the research team found that in postpartum mice, ibuprofen and celecoxib treatment reduced mammary tumor size, collagen architecture, COX-2 expression, and breast tumor cell spreading into the lung.

However, recommending ibuprofen for women undergoing breast involution is premature. Schedin and Borges point out that early studies of vitamin A in lung cancer and vitamin E in prostate cancer at first found the vitamins to be cancer-fighting but eventually showed them to be cancer-promoting. "It becomes a numbers game," says Borges, "with the benefit of the drug weighed against its dangers. It seems as if the safety of these drugs is self-evident, but it's only because we don't fully understand the effects of NSAIDs during this unique period of a woman's life, when her body is undergoing dramatic changes. So it becomes very important to study the effects of NSAID treatment in this particular group of women before we can make any prevention recommendations."

This is about the fifth step down an extremely promising path toward identifying a simple, inexpensive, effective treatment of postpartum breast cancers. But there are many steps still to go.


'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

Related medicine news :

1. Peak oil and public health: Political common ground?
2. Johns Hopkins scientists map genes for common form of brain cancer
3. Scientists May Have Found Missing Link to Common Brain Cancer
4. Common Swimming Injuries Often Avoidable
5. University of Maryland researchers discover possible drug targets for common non-Hodgkins lymphoma
6. RI Hospital researchers find common test may be unnecessary for bariatric surgery candidates
7. No increase in commonest preventable cause of intellectual disability over 20 years
8. Exposure to Common Chemicals May Affect Thyroid Function
9. Suicide Among Veterans All Too Common, Study Finds
10. Older Women at Greater Risk for Common STD, Study Suggests
11. Arthroscopic treatment of common hip problem improves range of motion
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2017)... ... ... “Congratulations! It's A Boy! God’s Gift: A Story of Love”: a children’s book that ... Boy! God’s Gift: A Story of Love” is the creation of published authors, Dale ... Christian Faith Publishing, Dale Anthony and Rachael Anthony’s new book is a perfect gift ...
(Date:8/18/2017)... ... ... ... For Immediate Release                Contact: Julian Teixeira, ... Women Seek Sex and Relationship Advice from their Fathers ...
(Date:8/18/2017)... New York, NY (PRWEB) , ... August 18, ... ... the launch of this summer’s edition of “Vision & Hearing,” advocating for active, ... The campaign focuses on resources available for individuals with hearing impairments and shares ...
(Date:8/18/2017)... O'Fallon, MO (PRWEB) , ... August 18, 2017 , ... ... Charles County, is inaugurating a new charity drive to generate community support for efforts ... for research into cures and treatments for all types of cancer. , Each ...
(Date:8/18/2017)... ... August 18, 2017 , ... Moore Insurance, a ... in east Texas, is launching a regional charity effort to provide publicity assistance ... the Pediatric Brain Tumor Foundation (PBTF) has raised nearly $30 million in donations ...
Breaking Medicine News(10 mins):
(Date:8/4/2017)... 3, 2017  Agragen, LLC, a ... the biopharmaceutical, nutraceutical, and aquacultural feed sectors, announces ... lead drug candidates, AGR131.  This drug is designed ... the blood of patients suffering from inflammatory conditions ... disease. Biological ...
(Date:8/2/2017)... Ore. , Aug. 2, 2017  Life Flight Network ... Agreement. The agreement improves patient care and operational efficiency for ... Springfield , Cottage Grove , ... level medical transportation. PeaceHealth and Life Flight Network work collaboratively ... available during transport, or when a time sensitive emergency exists. ...
(Date:7/31/2017)... , July 31, 2017 Three Tru-D SmartUVC ... South Korea . Tru-D, short for "Total Room Ultraviolet ... operating rooms after an environmental services (ES) professional cleans the area with ... ... "Although the BAACH ...
Breaking Medicine Technology: