Navigation Links
Common blood pressure medication may pose risk to older adults

Dallas June 12, 2014 Adults over 65 who have recently begun thiazide diuretics are at a greater risk for developing metabolic-related adverse events, researchers at UTSouthwestern Medical Center have found.

More than two-thirds of older adults have high blood pressure in the United States and thiazide diuretics are often recommended as the initial medication for these hypertensive patients. Thiazide diuretics primarily inhibit sodium transport in the kidney, leading to urinary loss of sodium and water, which decreases blood pressure. While the risks of this medication are well known, the risks are not well quantified in real-world clinical practice, where older adults who are treated may have a number of other illnesses.

The national observational study, undertaken by a team of researchers at UTSouthwestern and the University of California, San Francisco, examined 1,060 adult veterans with hypertension who recently began taking a thiazide diuretic. The study compared them to a similar group of veterans who were not prescribed a thiazide diuretic. The findings were recently published in the Journal of the American Geriatrics Society.

During a nine month period, 14 percent of older adults prescribed a thiazide diuretic developed a metabolic adverse event, compared with 6 percent of adults not prescribed a thiazide diuretic. For every 12 adults who were newly prescribed a thiazide diuretic, one developed a metabolic adverse event that he or she would not otherwise have had.

The three metabolic adverse events that researchers assessed were hyponatremia (low sodium levels in the blood), hypokalemia (low potassium levels in the blood), and acute kidney injury (a 25 percent decrease in kidney function from the baseline value before the thiazide diuretic was started).

"Our research quantifies the risks of metabolic adverse events in older adults in real-world, clinical practice shortly after initiating thiazide diuretics," said Dr. Anil Makam, assistant professor of Internal Medicine at UTSouthwestern and first author of the study. "From a clinical point-of-view, the implications of these findings help inform doctors of the risks associated with a common medication and their use in older adults."

While the findings highlight that thiazide-related adverse events are common in this population, researchers were surprised to discover that only 42 percent of older adults who had recently begun taking a thiazide diuretic had laboratory testing to monitor for these adverse events within the first three months of beginning the medication.

"Our research suggests that thiazide-induced adverse events are common in older adults and greater attention should be paid to potential complications in prescribing thiazide diuretics to older adults, including closer laboratory monitoring before and after initiation of thiazides," Dr. Makam said.

Contact: Lisa Warshaw
UT Southwestern Medical Center

Related medicine news :

1. Researchers uncover common heart drugs link to diabetes
2. Compounds in saliva and common body proteins may fend off DNA-damaging chemicals
3. Creatures of habit: Disorders of compulsivity share common pattern and brain structure
4. Gambling history is common among homeless people in Toronto, new study
5. Study debunks common myth that urine is sterile
6. Discovery links rare, childhood neurodegenerative diseases to common problem in DNA repair
7. Expert guidance strengthens strategies to prevent most common and costly infection
8. Complications from kidney stone treatments are common and costly
9. Unemployment common after breast cancer treatment
10. Vanderbilt study finds physical signs of depression common among ICU survivors
11. Pregnancy complications may be more common in immigrants from certain regions
Post Your Comments:
Related Image:
Common blood pressure medication may pose risk to older adults
(Date:6/26/2016)... ... June 26, 2016 , ... Many women ... diagnosed with endometriosis. These women need a treatment plan to not only alleviate ... that can help for preservation of fertility and ultimately achieving a pregnancy. The ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX ... Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms over ... Cut Pro X . Simply select a ProHand generator and drag it above media ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, ... at Work award to iHire in recognition of their exemplary accomplishments in worksite health ... annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle ... chronic pain and the benefits of holistic treatments, Serenity Recovery Center of ... Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the red ...
(Date:6/24/2016)... Francisco, CA (PRWEB) , ... June 24, 2016 ... ... CitiDent, is now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive ... self-ligating Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... Jazz Pharmaceuticals plc (Nasdaq: JAZZ ... Antitrust Improvements Act of 1976, as amended ("HSR"), with ... ("Celator"; Nasdaq: CPXX ) expired effective June ... As previously announced on May 31, 2016, Jazz ... under which Jazz Pharmaceuticals has commenced a tender offer ...
(Date:6/24/2016)... , June 24, 2016  Consumers have taken ... regulators/payers have placed more emphasis on patient outcomes. ... support programs in the pharmaceutical industry have evolved ... Consequently, pharmaceutical companies are focusing on becoming more ... providing products and services that improve health. ...
(Date:6/24/2016)... , June 24, 2016   Bay ... Rehabilitation Network,s Dean Center for Tick Borne ... Medicine and Rehabilitation, MIT Hacking Medicine, University of ... Innovation, today announced the five finalists of ... Lyme disease.  More than 100 scientists, clinicians, researchers, ...
Breaking Medicine Technology: