Navigation Links
Common anti-inflammatory coaxes liver cancer cells to commit suicide
Date:5/16/2011

s function.

"Normally, STAT3 is persistently activated in cancer cells. If you have a good molecule that sticks to STAT3, it will prevent its activation," Li said. And when STAT3 is inhibited, cellular survival pathways are blocked that cause the cancer cell to chop itself up and die.

The research appears online and is scheduled for later print publication in the journal Cancer Prevention Research.

The biological portion of the study further defined the role of a pro-inflammatory protein in liver cancer's development. The protein, called interleukin-6, or IL-6, is a cytokine, a chemical messenger that causes inflammation, which can have both beneficial and damaging effects in the body. Previous research by other scientists has shown that high levels of IL-6 in the blood are associated with hepatocellular carcinoma, the most common type of liver cancer.

Lin and colleagues determined that IL-6 initiates a chemical reaction called phosphorylation of STAT3. That reaction activates STAT3 inside liver cancer cells, where STAT3 in turn activates at least three other known genes that allow the cells to resist the effects of chemotherapy.

The scientists treated five different types of hepatocellular carcinoma cells with two different doses of celecoxib for two hours, and followed by giving them IL-6 for 30 minutes. The pre-treatment with the lower dose of celecoxib inhibited IL-6's ability to start the reaction that activates STAT3. The higher dose blocked STAT3 altogether.

The researchers then treated a line of liver cancer cells with celecoxib in combination with two chemotherapy drugs: doxorubicin, which is used to treat breast, ovarian, gastric, thyroid and several other cancers, and sorafenib, which is the only chemotherapy medication approved by the Food and Drug Administration for liver cancer treatment. Its brand name is Nexavar.

With both drugs, the addition of celecoxib treatment reduced the numb
'/>"/>

Contact: Jiayuh Lin
lin.674@osu.edu
614-722-5086
Ohio State University
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Mental Decline Common in Women Over 85: Study
2. New model taps tiny, common tropical fish for large-scale drug screening to combat Cushing disease
3. Post-traumatic stress disorder common following significant orthopedic trauma
4. DNA from common stomach bacteria minimizes effects of colitis, U-M study says
5. TVs Common in Daycare Centers, Flouting Guidelines
6. Common Painkillers May Blunt Antidepressants
7. Prenatal exposure to common insecticide linked to decreases in cognitive functioning at age 7
8. Depression Common After Brain Injury
9. Treatment-resistant epilepsy common in idiopathic autism
10. Can Common Virus, Lack of Sunlight Boost MS Risk?
11. Hookah Use Common Among College Students, Survey Finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... if a suspicious skin lesion is painful or itchy ... to be cancerous, according to a new study headed ... Dermatology at Temple University School of Medicine. , The ... July 23, 2014, found that nearly 36. 9 percent ... 28.2 percent involve pain. Non-melanoma skin cancers specifically, ...
(Date:7/23/2014)... Celebrating a decade of philanthropy in 2014, The ... of $1,070,000 in grants to 20 New Jersey non-profit ... Foundation’s 1,000th grant. , “The Horizon Foundation for New ... community-based organizations that are working to improve public health ... State,” said Robert A. Marino, Horizon Blue Cross Blue ...
(Date:7/23/2014)... Inventor and entrepreneur Delegate Joe T. May will ... pump – sharing his passion for technology and innovation ... , With 24 patents granted and three pending, this ... the General Assembly since Thomas Jefferson. Inventions credited to ... seen on television, an instrument for measuring octane on ...
(Date:7/23/2014)... News) -- Regularly checking the pulse of a stroke ... "Screening pulse is the method of choice for checking ... have never had a stroke. Our study shows it ... to identify people who might need more thorough monitoring ... Bernd Kallmunzer, of Erlangen University in Germany. ...
(Date:7/23/2014)... in Shaanxi province, and the University of California, Davis, ... groundwork for establishing the Sino-U.S. Joint Research Center for ... held in the city of Yingchuan, China, during a ... Agriculture and China,s Ministry of Science and Technology. , ... and for our World Food Center and serves as ...
Breaking Medicine News(10 mins):Health News:Research led by Temple's chair of dermatology: Pain and itch may be signs of skin cancer 2Health News:The Horizon Foundation for New Jersey Awards More than $1 million in Grants to 20 Non-profit Organizations 2Health News:The Horizon Foundation for New Jersey Awards More than $1 million in Grants to 20 Non-profit Organizations 3Health News:The Horizon Foundation for New Jersey Awards More than $1 million in Grants to 20 Non-profit Organizations 4Health News:The Horizon Foundation for New Jersey Awards More than $1 million in Grants to 20 Non-profit Organizations 5Health News:Celebrating Innovation and Invention 2Health News:Routine Pulse Check May Prevent Second Stroke, Study Says 2Health News:Global food safety research agreement signed by China and UC Davis 2Health News:Global food safety research agreement signed by China and UC Davis 3
... older women need screening as much as younger ones, ... screening should continue for women older than 50 -- ... because they have a similar level of risk as ... suggested there,s little benefit in repeating smear tests in ...
... recovered from unique virus , , THURSDAY, April 23 (HealthDay ... now been diagnosed with a unique form of swine ... people have recovered, Dr. Anne Schuchat, director of the ... for Immunization and Respiratory Diseases, said during an afternoon ...
... EFFINGHAM, Ill., April 23 Heartland Dental Care, Inc. ... care facilities during first quarter 2009.The six acquisitions include ... Phoenix, Ariz., Glendale, Ariz., and New Port Richie, Fla. ... locations in Lee,s Summit, Mo. and Dulles, Va. This ...
... WASHINGTON, April 23 The Food and Drug Administration ... expanded over-the-counter access to the morning-after pill, Levonorgestrel or ... adults. Deirdre McQuade, Assistant Director for Policy and Communications ... Pro-Life Activities, objected to the move in the following ...
... can be significantly reduced by providing a simple intervention ... and alternatives of various imaging modalities, according to a ... Island, NY. , "Given the increased awareness ... medical imaging we hypothesized that a simple intervention of ...
... Minn. -- An important genetic study conducted through ... alcoholism in subjects with European ancestry, according to ... Experimental Research . , Research findings ... specific genes and their variations associated with this ...
Cached Medicine News:Health News:Don't Lower Age for Cervical Cancer Test, Study Urges 2Health News:Swine Flu Cases Now Total 7: CDC 2Health News:Heartland Dental Care, Inc. Adds Eight Dental Practices In First Quarter 2009 2Health News:Pro-Life Spokeswoman Objects to FDA Approval of 'Morning-After Pill' for Minors Without Prescription 2Health News:Mayo clinic study finds gene bringing together animal and human research in alcoholism 2
(Date:7/23/2014)... , July 23, 2014 UBM Medica US ... a new online community and information resource for neurologists ... and treat their patients with neurological disorders . ... an aging population, necessitates greater access to dedicated information ... statistics on neurological conditions include: , 1 ...
(Date:7/23/2014)... July 23, 2014 Research and Markets ... Market in Consumer Healthcare by Application, Sensor Type & ... - 2020" report to their offering. ... been an increasing momentum for consumer healthcare monitoring and ... The consumer healthcare will lessen the healthcare cost of ...
(Date:7/23/2014)... Research and Markets  has announced the ... Product, End-user & by Lead Type - Global Forecast ... http://photos.prnewswire.com/prnh/20130307/600769 The global ... segments, namely, holter monitor, resting, and stress type diagnostic ... million in 2013 and is poised to grow at ...
Breaking Medicine Technology:UBM Medica US Launches NeurologyTimes.com 2UBM Medica US Launches NeurologyTimes.com 3Sensor Market in Consumer Healthcare (Patient Monitoring, Therapeutic, Handheld and Homecare, & Fitness and wellness) - Analysis & Forecast to to 2013 - 2020 2Sensor Market in Consumer Healthcare (Patient Monitoring, Therapeutic, Handheld and Homecare, & Fitness and wellness) - Analysis & Forecast to to 2013 - 2020 3Global Diagnostic Electrocardiograph (Resting, Stress, Holter Monitor) (ECG) Market - Forecast to 2020 2Global Diagnostic Electrocardiograph (Resting, Stress, Holter Monitor) (ECG) Market - Forecast to 2020 3
... custom bars have a large body ... contacts (spaced 3 centimeters center-to-center) to ... repeated cleaning. Polarity indicators are molded ... handle fits our bar electrode styles. ...
... the strongest vacuum force in ... The unit includes a ... plug, footswitch, built-in wheels, retractable ... ring to hold the liquid ...
A system for the removal and filtration of laser and surgical smoke....
Stryker Instruments, the leader in surgical helmets, offers its 4th generation of personal protection systems for todays surgical environment the Sterishield T4 System....
Medicine Products: