Navigation Links
Common anti-inflammatory coaxes liver cancer cells to commit suicide
Date:5/16/2011

COLUMBUS, Ohio The anti-inflammatory drug celecoxib, known by the brand name Celebrex, triggers liver cancer cell death by reacting with a protein in a way that makes those cells commit suicide, according to a new study.

Researchers also found that the combination of celecoxib with each of two chemotherapy drugs killed more liver cancer cells in culture, making those combinations more effective than either drug on its own.

"Each chemotherapy drug alone will reduce the growth of cancer cells, but when each single drug is combined with Celebrex, a greater growth suppression effect was observed," said Jiayuh Lin, senior author of the study and an associate professor of pediatrics at Ohio State University. "For clinicians, this research suggests the possibility of a new therapeutic strategy."

Celecoxib has this effect by acting on STAT3, a gene inside liver cancer cells that, when activated, allows those cancer cells to resist the effects of chemotherapy drugs. The researchers determined that the celecoxib molecule binds to STAT3 on so-called "hot spots," effectively blocking its ability to function.

Powerful computing techniques were employed before the researchers ever considered celecoxib as a potential treatment for cancer. Celebrex is a nonsteroidal anti-inflammatory drug, or NSAID, and a Cox-2 inhibitor, meaning it helps control inflammation by inhibiting an enzyme known as cyclooxygenase-2. It is most commonly prescribed to treat the pain of arthritis.

Chenglong Li, an assistant professor of medicinal chemistry and pharmacognosy at Ohio State, has developed computer simulations to identify optimal drug fragment combinations that attach simultaneously to proteins in ways that block the proteins' functions. By searching a database of existing federally approved drugs, he found that celecoxib was structurally similar to a template molecule that he had determined would most effectively bind to STAT3 and inhibit it
'/>"/>

Contact: Jiayuh Lin
lin.674@osu.edu
614-722-5086
Ohio State University
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Mental Decline Common in Women Over 85: Study
2. New model taps tiny, common tropical fish for large-scale drug screening to combat Cushing disease
3. Post-traumatic stress disorder common following significant orthopedic trauma
4. DNA from common stomach bacteria minimizes effects of colitis, U-M study says
5. TVs Common in Daycare Centers, Flouting Guidelines
6. Common Painkillers May Blunt Antidepressants
7. Prenatal exposure to common insecticide linked to decreases in cognitive functioning at age 7
8. Depression Common After Brain Injury
9. Treatment-resistant epilepsy common in idiopathic autism
10. Can Common Virus, Lack of Sunlight Boost MS Risk?
11. Hookah Use Common Among College Students, Survey Finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... percent of patients undergoing breast cancer surgery require additional ... cancerous tissue in the initial operation. However, researchers at ... tool they developed that will help surgeons better distinguish ... chances for repeat operations. , The ... 2014 in the Proceedings of the National Academy ...
(Date:9/22/2014)... South Asians living in Canada have a higher rate ... compared with while people, McMaster researchers have found. ... Canadian Medical Association Journal (CMAJ Open) and may ... the fastest-growing ethnic groups in the country is the ... Canada, comprising about three percent of the population. They ...
(Date:9/22/2014)... 2014 Quincy Bioscience, one of ... promotes National Self-Improvement Month this September. ... should have access to self-improvement resources, especially for ... demand for products that preserve health is growing ... For over six years, Quincy Bioscience has been ...
(Date:9/22/2014)... York, New York (PRWEB) September 22, 2014 ... associated with the use of power morcellators ( ... LLP notes a new report detailing the continued ... warnings from federal regulators that specifically discouraged these ... physicians believe that the potential cancer risks associated ...
(Date:9/22/2014)... CareFlight Air & Mobile Services of Miami ... N3+ Dauphin, the latest version of Airbus Helicopters outstanding ... at Miami Valley Hospital in Dayton, Ohio, ... helicopters. , “We have a lot of confidence in ... Emergency, Trauma, and CareFlight. “We’ve been operating Dauphins for ...
Breaking Medicine News(10 mins):Health News:The fine line between breast cancer and normal tissues 2Health News:Higher risk of heart disease for South Asians in Canada 2Health News:Quincy Bioscience Promotes National Self-Improvement Month 2Health News:Power Morcellator News: Bernstein Liebhard LLP Notes New Report Detailing Continued Use of Uterine Morcellation Despite FDA Warning 2Health News:Power Morcellator News: Bernstein Liebhard LLP Notes New Report Detailing Continued Use of Uterine Morcellation Despite FDA Warning 3Health News:Power Morcellator News: Bernstein Liebhard LLP Notes New Report Detailing Continued Use of Uterine Morcellation Despite FDA Warning 4Health News:Miami Valley Hospital CareFlight begins Service with AS365 N3+ 2Health News:Miami Valley Hospital CareFlight begins Service with AS365 N3+ 3
... Discoveries are exciting but roadblocks remain, experts say , , ... future, people may routinely have doctors scan their personal ... help prevent, spot or treat a cancer. , "We ... a revolution in cancer care," said Dr. Len Lichtenfeld, ...
... With the Help of Leading Medical and Lifestyle Experts ... - the National Psoriasis Foundation is Empowering ... Expanded Web Resources, NEW YORK, Sept. 15 ... have a new resource. Today,the National Psoriasis Foundation officially ...
... disorder is widespread but can be prevented , FRIDAY, Sept. ... the diagnosis, management and prevention of a widespread, deadly lung ... 15 percent to 25 percent of adults over the age ... in the United States. It,s expected to become the fifth ...
... way to motivate the billion people in the world ... an overwhelming task, but a University of Houston professor ... his own. , Ioannis Pavlidis, a UH computer science ... have developed a computer game that translates physical activity ...
... Mozambique, Sept. 14 Aid provided by,The Prem Rawat ... 300 women and their families who were victims of ... After the flooding, caused by cyclones in this ... were displaced from their homes. The,Prem Rawat Foundation made ...
... 14 MAKO Surgical Corp., a,developer of minimally ... today that Frederic H. Moll, M.D.,has been named ... 24,2007. Dr. Moll has over 20 years ... co-founded Hansen Medical Inc. in September 2002 and,currently ...
Cached Medicine News:Health News:Genetics Hold Promise, Challenges for Cancer Care 2Health News:Genetics Hold Promise, Challenges for Cancer Care 3Health News:Genetics Hold Promise, Challenges for Cancer Care 4Health News:Empowerment Program Gets Patients on the PATH to Managing the Physical and Emotional Effects of Psoriatic Arthritis 2Health News:Empowerment Program Gets Patients on the PATH to Managing the Physical and Emotional Effects of Psoriatic Arthritis 3Health News:Experts Publish New Lung Disease Guidelines 2Health News:Weight loss game looking for 'NEAT-o' results 2Health News:The Prem Rawat Foundation Supports Disaster-Relief Efforts in Mozambique 2Health News:MAKO Surgical Corp. Names Frederic H. Moll, M.D. to Board of Directors 2
(Date:9/22/2014)... Pa. , Sept. 22, 2014  Inovio ... today it has initiated a phase I clinical ... will evaluate the safety, tolerability, and immunogenicity of ... (HPV-6), which causes most aerodigestive cancers. ... throat, vocal cords, and parts of the esophagus ...
(Date:9/22/2014)... and NEW YORK , ... (OTCBB: ACCP), has signed an exclusive, global license ... development and commercialization of its proprietary plasma fractionation ... management team and its intention to strategically refocus ... and its plans to pursue a national listing ...
(Date:9/22/2014)... Sept. 22, 2014 Auxilium Pharmaceuticals, Inc. ... company, today announced that its Board of Directors ... conditional proposal from Endo International plc ("Endo") and, ... advisors, has unanimously determined it is not a ... merger agreement with QLT Inc. ("QLT") and has ...
Breaking Medicine Technology:Inovio Pharmaceuticals Expands HPV Immunotherapy Development to Aerodigestive Cancers 2Inovio Pharmaceuticals Expands HPV Immunotherapy Development to Aerodigestive Cancers 3Inovio Pharmaceuticals Expands HPV Immunotherapy Development to Aerodigestive Cancers 4Access Pharmaceuticals Announces Exclusive Global Plasma Therapeutics License, New Management And New Corporate Name 2Access Pharmaceuticals Announces Exclusive Global Plasma Therapeutics License, New Management And New Corporate Name 3Access Pharmaceuticals Announces Exclusive Global Plasma Therapeutics License, New Management And New Corporate Name 4Access Pharmaceuticals Announces Exclusive Global Plasma Therapeutics License, New Management And New Corporate Name 5Access Pharmaceuticals Announces Exclusive Global Plasma Therapeutics License, New Management And New Corporate Name 6Auxilium Provides Transaction Update 2Auxilium Provides Transaction Update 3Auxilium Provides Transaction Update 4Auxilium Provides Transaction Update 5Auxilium Provides Transaction Update 6
... DecisionView Inc., a leading provider of ... life sciences companies, today announced the release of ... flagship solution for patient enrollment planning, tracking and ... into site performance and cost projections, StudyOptimizer 4.3 ...
... 19, 2011 Reportlinker.com announces that ... available in its catalogue: ... http://www.reportlinker.com/p0358494/North-American-External-Defibrillator-Market.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Cardiovascular_Devices ... state of the North American external ...
Cached Medicine Technology:DecisionView StudyOptimizer 4.3™ Enhances Market-Leading Enrollment Optimization Solution With Greater Visibility Into Site Performance and Cost Forecasting 2DecisionView StudyOptimizer 4.3™ Enhances Market-Leading Enrollment Optimization Solution With Greater Visibility Into Site Performance and Cost Forecasting 3North American External Defibrillator Market 2North American External Defibrillator Market 3North American External Defibrillator Market 4North American External Defibrillator Market 5North American External Defibrillator Market 6
... of German Craftsmanship have produced ... the world. Ocutek® now makes ... holders of the coveted Meisterbrief ... apprenticeship, are qualified to become ...
... Centuries of German Craftsmanship ... instrumentation in the world. Ocutek ... you! Only holders of the ... and eight-year apprenticeship, are qualified ...
... of German Craftsmanship have produced ... the world. Ocutek now makes ... holders of the coveted Meisterbrief ... apprenticeship, are qualified to become ...
... platform with integrated neck. Piston assembly ... an internal spring to recoil back ... Block fits into precision milled cavity ... sized 6.25 - 9.0mm. Designed for ...
Medicine Products: