Navigation Links
Common Heart Drug Might Improve Lung Cancer Survival
Date:1/9/2013

By Steven Reinberg
HealthDay Reporter

WEDNESDAY, Jan. 9 (HealthDay News) -- New research suggests that beta blockers, medications that are used to control blood pressure and heart rhythms, may also help lung cancer patients live longer.

The researchers found that patients with non-small-cell lung cancer being treated with radiation lived 22 percent longer if they were also taking these drugs.

"These findings were the first, to our knowledge, demonstrating a survival benefit associated with the use of beta blockers and radiation therapy for lung cancer," said lead researcher Dr. Daniel Gomez, an assistant professor in the department of radiation oncology at the University of Texas M.D. Anderson Cancer Center in Houston.

"The results imply that there may be another mechanism, largely unexplored, that could potentially reduce the rates of tumor spread in patients with this very aggressive disease," he added.

The report was published Jan. 9 in the Annals of Oncology.

For the study, Gomez's team compared the outcomes of more than 700 patients undergoing radiation therapy for lung cancer.

The investigators found that the 155 patients taking beta blockers for heart problems lived an average of almost two years, compared with an average of 18.6 months for patients not taking these drugs.

The findings held even after adjusting for other factors such as age, stage of the disease, whether or not chemotherapy was given at the same time, presence of chronic obstructive pulmonary disease and aspirin use, the researchers noted.

Beta blockers also improved survival without the disease spreading to other parts of the body and survival without the disease recurring, they added.

Beta blockers, however, made no difference in the length of survival without the disease progressing in the part of the lungs where it started, the study authors pointed out.

How beta blockers might slow cancer's spread isn't known. However, the researchers speculate that these drugs may work by suppressing a hormone called norepinephrine, which is known to promote the spread of cancer cells.

"Right now, we would not advocate that patients take beta blockers for this purpose, until these findings can be validated by prospective trials," Gomez said. "In addition, future studies will help us to understand if the mechanism that we propose is correct, and thus if beta blockers are indeed directly affecting the aggressiveness of this cancer or if these findings are due to the activation or inhibition of another pathway."

For one expert, the study raises more questions than it answers.

"It is unclear whether beta blockers need to be started before the cancer is found, or if they still have a utility once the diagnosis is made," said Dr. Len Horovitz, a pulmonologist at Lenox Hill Hospital in New York City.

In addition, Horovitz wonders whether other drugs that block hormones might serve the same purpose.

One thing is clear, however, he added. People should not start taking beta blockers in hopes of preventing or controlling lung cancer, he said.

Horovitz did say he thinks trials testing whether or not beta blockers or other hormone-blocking drugs prevent the spread of lung cancer should be done.

Although the study found a link between beta blocker use in patients undergoing radiation therapy and increased non-small-cell lung cancer survival, it did not prove cause-and-effect.

More information

For more on lung cancer, visit the U.S. National Cancer Institute.

SOURCES: Daniel Gomez, M.D., assistant professor, department of radiation oncology, University of Texas M.D. Anderson Cancer Center, Houston; Len Horovitz, M.D., pulmonologist, Lenox Hill Hospital, New York City; Jan. 9, 2013, Annals of Oncology


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Researchers reveal most effective treatment for common kidney disorder
2. Binge Drinking Common Among U.S. Women, Girls: CDC
3. Researchers identify new target for common heart condition
4. Common Blood Pressure Drugs Might Lower Dementia Risk
5. Psychological common ground could ease tensions among those with different religious beliefs
6. What do cyborgs, shale gas and TSCA reform have in common?
7. Common data determinants of recurrent cancer are broken, mislead researchers
8. Dr. Alavi Responds to Common Plastic Surgery Myths
9. Car Crashes Common for Sleepy Doctors in Training: Study
10. Probiotic Action Responds to Article Answering Common Questions About Acne
11. Some Kids Abusing Common Baking Ingredients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Common Heart Drug Might Improve Lung Cancer Survival
(Date:6/23/2017)... ... June 23, 2017 , ... Ulster University, Magee Campus ... from 9 am to 3 pm to present to graduate students exciting new and ... an original curriculum project led by The Health Improvement Service of the Western Health ...
(Date:6/23/2017)... ... June 23, 2017 , ... Radabaugh & Associates, ... families and business owners in North Central West Virginia, is embarking on a ... differently abled residents in the region. , The Stepping Stones organization offers a ...
(Date:6/22/2017)... Indianapolis, IN (PRWEB) , ... June 22, 2017 ... ... employee benefits advisory organization, is pleased to welcome Whipple & Company as its ... on the clear purpose of balancing their clients’ risk while tailoring optimized benefit ...
(Date:6/22/2017)... , ... June 22, 2017 , ... ... awards for environmental excellence. Maryland Recycling Network has awarded the Baltimore VA Medical ... Outstanding Small Government Program Award for its efforts to promote waste reduction and ...
(Date:6/20/2017)... ... June 20, 2017 , ... ... that Claritas Capital, a Nashville-based private equity firm, has invested $3.35 million in ... for some time, and Claritas Capital offers the smart money, speed to market ...
Breaking Medicine News(10 mins):
(Date:6/8/2017)... 8, 2017  Less than a month ago, amateur ... 200,000 companies, including hospital networks, in over 150 countries. ... of the largest online extortion attempts ever recorded. With ... it is imperative that providers understand where the risks ... this — and many other very real cyber threats.  ...
(Date:6/7/2017)... GAITHERSBURG, Md. , June 7, 2017  Novavax, Inc., ... the second of two Phase 2 trials of its RSV ... women of child bearing age have been published in the ... this publication have been shared in prior scientific conferences). The ... trial in April 2014. Novavax is developing the RSV F ...
(Date:6/3/2017)... -- Eli Lilly and Company (NYSE: LLY ... 3 MONARCH 2 study showed that abemaciclib, a ... with fulvestrant, significantly improved progression-free survival (PFS) compared ... hormone-receptor-positive (HR+), human epidermal growth factor receptor 2-negative ... progressed after endocrine therapy (median PFS, 16.4 vs. ...
Breaking Medicine Technology: