Navigation Links
Common Genetic Variant Tied to Lung Cancer Risk
Date:5/27/2008

It may explain why some nonsmokers contract the disease, study says

TUESDAY, May 27 (HealthDay News) -- A common genetic variant increases the risk of lung cancer, even in nonsmokers, researchers report.

The findings -- that certain forms of the alpha1-antitrypsin gene double someones risk of developing lung cancer, regardless of whether he or she ever smoked -- could help explain why some nonsmokers develop the disease, said study author Dr. Ping Yang, of the Mayo Clinic.

The study also sheds light on why some smokers never develop lung cancer while others do, added William Phelps, scientific program director at the American Cancer Society.

"Part of the reason may be changes like this that are fairly common in the population," he said. "It is a common mutation that adds a modest amount of risk."

Alpha1-antitrypsin (AT) gene deficiencies are among the most common genetic disorders in the United States, affecting at least 10 million Americans. An estimated 11 percent to 12 percent of lung cancer patients in the study carried the defective gene variants, said the study authors, who published their findings in the May 26 issue of Archives of Internal Medicine.

According to Yang, the link between AT deficiency (ATD) and lung cancer involves another disease called chronic obstructive pulmonary disease (COPD). People with COPD are at greater risk of lung cancer, and the diseases often coexist in families, suggesting a genetic link. People with two abnormal copies of the AT gene develop early onset emphysema and ultimately COPD. But those with just one bad copy often have no symptoms at all, the study authors said.

"These carriers may be more vulnerable to carcinogen-containing tobacco smoke than non-carriers in developing lung cancer, especially when their alpha1-AT levels are compromised under physiological stress or have sub-clinical lung tissue damage," Yang explained.

'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Page: 1 2 3

Related medicine news :

1. UK junior doctors gaining less experience of common procedures
2. New insights into common knee injuries
3. High and mighty: first common height gene identified by researchers behind obesity gene finding
4. Figure Skater Peggy Fleming, HealthSaver Says: Take Pains For Back Strains, 2nd Most Common Doctor Complaint
5. Exelixis Commences Public Offering of Common Stock
6. Common misdiagnosis: most women believe they have a yeast infection when they dont
7. Business Executives Discuss National Health Care Reform at Conference Sponsored by The Century Foundation, with Support from The Commonwealth Fund, and AARP
8. New Expert Report Dispels Common Myths About Aspartame
9. Common Foot Myths Trip Us Up
10. AHPC Holdings, Inc. Announces Intent to Deregister Common Stock With Securities and Exchange
11. Allergy-Induced Asthma More Common in Affluent Countries
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2015)... March 28, 2015 "Necrorun" was featured ... takes a look at the latest and coolest applications ... Troohey, the host of NewsWatch and technology expert, conducted ... is an entertaining endless runner game with knights, nature, ... was released in 2009, according to Eurogamer. The popularity ...
(Date:3/28/2015)... 28, 2015 The California-based leading wig ... every customer shopping on UniWigs during the Easter Holidays ... a big promotion on April Fools’ Day. , As ... just around the corner. Easter Festival, with religious origins ... a major holiday after Christmas. The best wig provider, ...
(Date:3/28/2015)... Centurion Service Group will be hosting a ... 2 at their Las Vegas warehouse, located at 4606 Andrews ... which consists of equipment from hospitals and surgery centers from ... PDT. , Buyers will find items of all types ... a one-stop-shop,” said Erik Tivin, CEO of Centurion. , Among ...
(Date:3/28/2015)... March 28, 2015 Delaying rotator cuff ... necessary, according to research presented today at the American ... Day. , “Our study compared results for 170 patients ... an additional glenohumeral joint capsule release procedure to relieve ... MD, PhD, lead author from St. George Hospital in ...
(Date:3/28/2015)... Portland, OR (PRWEB) March 28, 2015 ... in the media regarding recent changes and proposals around ... TV , current and former collegiate student-athletes across a ... experiences and reflect on common challenges. The special panel ... the country in sports ranging from football, track and ...
Breaking Medicine News(10 mins):Health News:A Grim Endless Runner Game Was Featured on NewsWatch Television on January 30, 2015 2Health News:UniWigs Is Sending Out Mysterious Gifts During the Easter Holidays 2Health News:Medical Equipment Auction to Take Place in North Las Vegas 2Health News:No Need to Delay Rotator Cuff Surgery, Study Shows 2Health News:SCI TV Panel of Former College Athletes Discusses Student Athlete Experience 2Health News:SCI TV Panel of Former College Athletes Discusses Student Athlete Experience 3
... created the world's first canine clone, have cloned another breed ... the water and bird hunting// skills. ,A ... College of Veterinary Medicine of Seoul National University (SNU) cloned ... team, formerly led by the nation's disgraced stem cell scientist ...
... the earth, according to a study by Auckland University. This ... foods// cost substantially more. ,The study suggests that ... obtained for just $7 more a week. ... unit said, "Our research has shown that making some important ...
... in the January 24/31 issue of JAMA, Patients with ... West African// country of Senegal, had higher cure and ... communication with health personnel and community involvement. ... in the global fight against tuberculosis (TB). Reasons for ...
... moderation offers no harm to an expectant mother, in terms ... ,This study performed by researcher Dr Bodil Hammer Bech and ... online by the British Medical Journal. , ... commencing before 20 weeks into their pregnancy. ,The ...
... In a new study from The American Journal of ... and Ruqi Tang (Shanghai Jiao Tong University) present// evidence ... ,Specifically, their findings identify the chitinase 3-like ... that the genes involved in biological response to adverse ...
... may want to tune into more weather forecasts. //Weather patterns ... an epidemic is imminent because they determine the conditions for ... techniques can help quicken the response to viral outbreaks worldwide ... global warming is adding urgency to such strategies for fighting ...
Cached Medicine News:Health News:Seoul Lab Clones Poodle 2Health News:TB Intervention Program Improves Patient Outcomes 2Health News:Coffee Addicts With Baby, Take Heart 2Health News:Scientists Identify Gene That May Indicate Predisposition To Schizophrenia 2Health News:Experts Use Weather to Predict Disease 2
(Date:3/27/2015)... , March 27, 2015  The quality function within ... ensure products meet quality standards at every stage of ... regulations, quality leaders also have the challenge of balancing ... Those who don,t effectively balance these priorities risk ... as marketplace failure and regulatory scrutiny. For ...
(Date:3/27/2015)... /PRNewswire/ - Medicure Inc. (the "Company") (TSXV:MPH, OTCQB:MCUJF) announces ... grant of an aggregate of 236,070 options to certain ... the Company pursuant to the Company,s Stock Option Plan. ... the tenth anniversary of the date of grant, 5,000 ... the date of grant and 50,000 are set to ...
(Date:3/27/2015)... , March 27, 2015 Biopharmaceutical Industry ... biopharmaceutical industry comes out on top as the country,s ... new report  from ndp│analytics. According to the  analysis ... (R&D) investment over the last decade, accounting for 27 ... A Short Video on Medicare Part ...
Breaking Medicine Technology:New Medical Device Quality Study Finds Regulatory Environment is Boosting Quality Spending, Especially for Large Companies 2Week in Review: The Latest from PhRMA 2
... SHENZHEN, China , May 6 /PRNewswire-Asia-FirstCall/ -- China Nepstar Chain,Drugstore Ltd. ... in China based on the number of directly operated stores,announced today ... March 31, 2010 , before the market opens on, Wednesday, May 19, ... ...
... SCOLR Pharma, Inc. (NYSE AMEX: DDD ... Agreement with RedHill Biopharma Ltd. an Israeli corporation, (RedHill), ... ondansetron tablet formulations based on SCOLR,s proprietary extended delivery ... Zofran®, GlaxoSmithKline,s drug to prevent chemotherapy and radiation related ...
Cached Medicine Technology:China Nepstar Chain Drugstore Reports First Quarter 2010 Results on May 19 2China Nepstar Chain Drugstore Reports First Quarter 2010 Results on May 19 3SCOLR Pharma, Inc. Enters into Worldwide Licensing Agreement with RedHill Biopharma Ltd. 2SCOLR Pharma, Inc. Enters into Worldwide Licensing Agreement with RedHill Biopharma Ltd. 3
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: