Navigation Links
Common Genetic Variant Tied to Lung Cancer Risk
Date:5/27/2008

It may explain why some nonsmokers contract the disease, study says

TUESDAY, May 27 (HealthDay News) -- A common genetic variant increases the risk of lung cancer, even in nonsmokers, researchers report.

The findings -- that certain forms of the alpha1-antitrypsin gene double someones risk of developing lung cancer, regardless of whether he or she ever smoked -- could help explain why some nonsmokers develop the disease, said study author Dr. Ping Yang, of the Mayo Clinic.

The study also sheds light on why some smokers never develop lung cancer while others do, added William Phelps, scientific program director at the American Cancer Society.

"Part of the reason may be changes like this that are fairly common in the population," he said. "It is a common mutation that adds a modest amount of risk."

Alpha1-antitrypsin (AT) gene deficiencies are among the most common genetic disorders in the United States, affecting at least 10 million Americans. An estimated 11 percent to 12 percent of lung cancer patients in the study carried the defective gene variants, said the study authors, who published their findings in the May 26 issue of Archives of Internal Medicine.

According to Yang, the link between AT deficiency (ATD) and lung cancer involves another disease called chronic obstructive pulmonary disease (COPD). People with COPD are at greater risk of lung cancer, and the diseases often coexist in families, suggesting a genetic link. People with two abnormal copies of the AT gene develop early onset emphysema and ultimately COPD. But those with just one bad copy often have no symptoms at all, the study authors said.

"These carriers may be more vulnerable to carcinogen-containing tobacco smoke than non-carriers in developing lung cancer, especially when their alpha1-AT levels are compromised under physiological stress or have sub-clinical lung tissue damage," Yang explained.

'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Page: 1 2 3

Related medicine news :

1. UK junior doctors gaining less experience of common procedures
2. New insights into common knee injuries
3. High and mighty: first common height gene identified by researchers behind obesity gene finding
4. Figure Skater Peggy Fleming, HealthSaver Says: Take Pains For Back Strains, 2nd Most Common Doctor Complaint
5. Exelixis Commences Public Offering of Common Stock
6. Common misdiagnosis: most women believe they have a yeast infection when they dont
7. Business Executives Discuss National Health Care Reform at Conference Sponsored by The Century Foundation, with Support from The Commonwealth Fund, and AARP
8. New Expert Report Dispels Common Myths About Aspartame
9. Common Foot Myths Trip Us Up
10. AHPC Holdings, Inc. Announces Intent to Deregister Common Stock With Securities and Exchange
11. Allergy-Induced Asthma More Common in Affluent Countries
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... Pools and beaches are the place to be ... especially for small children, so Amica Insurance is ... the Centers for Disease Control and Prevention, children between the ... water-related injuries and deaths. It’s important to know the best ... is offering the following tips from the American Red Cross:, ...
(Date:7/24/2014)... Drinking caffeine may worsen the hot flashes and night ... go through menopause, new survey data suggests. "While ... caffeine intake may be useful for those postmenopausal women ... researcher Dr. Stephanie Faubion, director of the Women,s Health ... But caffeine -- a stimulant found in coffee and ...
(Date:7/24/2014)... (PRWEB) July 24, 2014 Horizon BCBSNJ’s ... give one lucky family a rent-free week in a ... August 3, 2014. Don’t miss your chance to win ... is open to all New Jersey residents, 25 or ... Facebook page, http://www.facebook.com/HorizonBCBSNJ . , “A family ...
(Date:7/24/2014)... Carnegie Mellon University, working with high-throughput data generated ... Laboratory, have devised a computational method to determine ... cells turn malignant and as they respond to ... how genes interact with each other in laboratory-grown ... by the online journal PLOS Computational Biology ...
(Date:7/24/2014)... Human Papillomavirus Vaccination (HPV) even after becoming sexually ... results than those who were never vaccinated. These ... Diseases . , Researchers from Boston University ... conducted a cross-sectional study of 235 women age ... HPV status and demographic and behavioral characteristics were ...
Breaking Medicine News(10 mins):Health News:Keep Kids Safe in the Water with 5 Tips from Amica 2Health News:Is Coffee Aggravating Your Hot Flashes? 2Health News:(Beach) Sands of Time Running out to Enter Horizon Blue Cross Blue Shield of New Jersey’s 2014 “Back to the Boardwalk” Sweepstakes 2Health News:Gene changes in breast cancer cells pinpointed with new computational method 2Health News:Gene changes in breast cancer cells pinpointed with new computational method 3
... recognized,anesthesiologist, Dr. Barry L. Friedberg was an invited speaker ... Anesthesiologists. , (Photo: ... His first lecture ,Why is minimally invasive ... ,PK 101, minimally invasive,anesthesia for minimally invasive surgery., , ...
... and Solutions Medical Billing Team Up To Offer a Unique Medical Claims ... ... and London (PRWEB) December 2, 2008 -- Making medical insurance claims is ... phase of a "Claims in a Cloud" software as a service (SaaS) ...
... provider of onsite health services and technology solutions, has announced that ... develop, implement and manage onsite health clinics and to provide health ... ... Burlington, VT (PRWEB) December 2, 2008 -- Marathon Health, ...
... Persons is recognized on Dec. 3, Mercy Ships celebrates with the story ... onboard the Africa Mercy, a floating hospital docked in Liberia, Benedict,s feet ... children his age. High resolution photos and video can be ... ...
... announces that the SouthEast Alaska Regional Health Consortium ... Integration Engine to help the different electronic health ... with each other. It also plans to extend ... State of Alaska immunization registry) and AKAIMS (an ...
... 2 Motorola, Inc. (NYSE: MOT ... powerbroadband system to enable,three hospitals managed by leading ... voice, data and video services. The innovative,Motorola solution ... services delivered over the existing telephone line, eliminating,the ...
Cached Medicine News:Health News:Corporate Modelling Partners Start Selling BPM in Cloud Service 2Health News:Marathon Health Joins Forces with New Balance for Employee Health - Associate Health Services Provided at Three Maine Locations 2Health News:Marathon Health Joins Forces with New Balance for Employee Health - Associate Health Services Provided at Three Maine Locations 3Health News:Mercy Ships Recognizes International Day of Disabled Persons 2Health News:Mercy Ships Recognizes International Day of Disabled Persons 3Health News:SouthEast Alaska Regional Health Consortium Selects Orion Health's Rhapsody Integration Engine for Full-scale Application Integration and Monitoring 2Health News:SouthEast Alaska Regional Health Consortium Selects Orion Health's Rhapsody Integration Engine for Full-scale Application Integration and Monitoring 3Health News:Motorola Extends the Delivery of Personalized Media Experiences to Hospital Group Generale De Sante 2Health News:Motorola Extends the Delivery of Personalized Media Experiences to Hospital Group Generale De Sante 3
(Date:7/24/2014)... 24, 2014 /PRNewswire-iReach/ -- Delivery of the Report ... placed. Photo - http://photos.prnewswire.com/prnh/20140723/129707 ... in-depth market survey on Global and Chinese Hemodialysis ... information of Hemodialysis Machine including its classification, application ... and China,s top manufacturers of Hemodialysis Machine listing ...
(Date:7/24/2014)... Cancer patients in the west of ... closer to home when a new radiotherapy center opens near ... (NYSE: VAR ) has been selected to equip ... for four TrueBeam™ medical linear accelerators. Two ... radiotherapy and radiosurgery treatments, will replace older treatment machines at ...
(Date:7/24/2014)... -- Blueprint Medicines (Blueprint), a leader in discovering highly selective ... the appointment of Jeffrey Albers as chief ... ASA, where he served on the executive management team ... Mr. Albers succeeds Alexis Borisy , co-founder and ... Ventures, who will remain an active member of the ...
Breaking Medicine Technology:Hemodialysis Machine Industry for Global and Chinese Markets Forecast to 2019 2Hemodialysis Machine Industry for Global and Chinese Markets Forecast to 2019 3Hemodialysis Machine Industry for Global and Chinese Markets Forecast to 2019 4Hemodialysis Machine Industry for Global and Chinese Markets Forecast to 2019 5Varian Medical Systems Selected to Equip First Satellite Radiotherapy Center in Scotland 2Varian Medical Systems Selected to Equip First Satellite Radiotherapy Center in Scotland 3Blueprint Medicines Appoints Jeffrey Albers as Chief Executive Officer 2
... The Iowa Health Information Technology Regional Extension Center (HITREC) has ... health record (EHR), practice management and interoperability solution PrimeSuite® , ... the federal Department of Health and Human Services (HHS) REC ... , , ...
... , SAN DIEGO , PARSIPPANY, N.J. and INDIANAPOLIS ... Eli Lilly and Company announced today that the companies have entered into ... about antiplatelet therapy and the role of platelet function testing. , ... Several factors, including a patient,s genetic ...
Cached Medicine Technology:Iowa Regional Extension Center Selects Greenway EHR Solutions 2Iowa Regional Extension Center Selects Greenway EHR Solutions 3Iowa Regional Extension Center Selects Greenway EHR Solutions 4Iowa Regional Extension Center Selects Greenway EHR Solutions 5Accumetrics, Inc., Daiichi Sankyo, Inc. and Eli Lilly and Company Launch Strategic U.S. Collaboration 2Accumetrics, Inc., Daiichi Sankyo, Inc. and Eli Lilly and Company Launch Strategic U.S. Collaboration 3Accumetrics, Inc., Daiichi Sankyo, Inc. and Eli Lilly and Company Launch Strategic U.S. Collaboration 4
Extremely wide blade opening. Excellent bio and MRI compatibility. Lot number on each clip. Long reliable history. Large type 1/1 (mm), opening width 12.0 mm and length 18 mm....
Extremely wide blade opening. Excellent bio and MRI compatibility. Lot number on each clip. Long reliable history. Large type 1/1 (mm), opening width 13.0 mm and length 15 mm....
Extremely wide blade opening. Excellent bio and MRI compatibility. Lot number on each clip. Long reliable history. Standard type 1/1 (mm), opening width 8.0 mm and length 9 mm....
Extremely wide blade opening. Excellent bio and MRI compatibility. Lot number on each clip. Long reliable history. Standard type 1/1 (mm), opening width 9.0 mm and length 8 mm....
Medicine Products: