Navigation Links
Common Chemotherapy Drug Linked to Memory Problems
Date:4/21/2008

in why the cognitive ill effects persist in some patients.

For the new study, Noble and his colleagues exposed cell lines in a laboratory and in mice to doses of 5-FU, and then evaluated the drug's effects. The drug is used to treat malignancies of the breast, ovaries, stomach, colon and other sites.

The researchers found that 5-FU damaged specific kinds of cells in the central nervous system -- immature cells known as progenitor cells, which later differentiate into specialized cells.

Also damaged were cells called oligodendrocytes, which help produce myelin, the fatty substance that coats nerve cells and facilitates communication between cells.

"The damage at eight weeks was considerably greater than one day after treatment," Noble said. "Damage at six months was even greater than at six weeks."

The finding "means that there is a real physiological basis for the symptoms of 'chemobrain,'" said Dr. Christina A. Meyers, chief of the department of neuro-oncology at M.D. Anderson Cancer Center, in Houston, who wrote an accompanying comment. "Until we know enough to develop targeted treatments for it, there is still lots to do about it [and better to have it than the alternative]." Among the remedies are relaxation training to focus attention, exercise, cognitive rehabilitation and medicine such as anti-inflammatory agents, she said.

Another cancer expert praised the study.

"This is a very good animal model," said Dr. Patricia Ganz, director of cancer prevention and control at the University of California, Los Angeles Jonsson Cancer Center.

But she added a caveat: "This does not mean that everybody receiving this drug will have damage to their brain," she said. And, she added, this is the effect of just one chemotherapy drug, 5-FU. Today, 5FU is "rarely used in breast cancer treatment," she said.

Noble hopes to focus next on why the damage continues. Eventually, his research m
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved

Page: 1 2 3

Related medicine news :

1. UK junior doctors gaining less experience of common procedures
2. New insights into common knee injuries
3. High and mighty: first common height gene identified by researchers behind obesity gene finding
4. Figure Skater Peggy Fleming, HealthSaver Says: Take Pains For Back Strains, 2nd Most Common Doctor Complaint
5. Exelixis Commences Public Offering of Common Stock
6. Common misdiagnosis: most women believe they have a yeast infection when they dont
7. Business Executives Discuss National Health Care Reform at Conference Sponsored by The Century Foundation, with Support from The Commonwealth Fund, and AARP
8. New Expert Report Dispels Common Myths About Aspartame
9. Common Foot Myths Trip Us Up
10. AHPC Holdings, Inc. Announces Intent to Deregister Common Stock With Securities and Exchange
11. Allergy-Induced Asthma More Common in Affluent Countries
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/12/2014)... July 12, 2014 As reported in ... of Standards and Technology), the June 25th, 2014 Supreme Court ... discovery world. It was also met with both ... on whether it was seen from an individual privacy perspective, ... is fact, there is now precedent which will require law ...
(Date:7/12/2014)... July 12, 2014 A recent article released ... a trio of suggestions for those seeking cosmetic surgical ... are rapidly approaching and the heat begins to enliven the ... their summer clothing, realizing that they didn’t work out as ... This can cause a sudden surge of people eager to ...
(Date:7/12/2014)... Seattle, Wa (PRWEB) July 12, 2014 ... by Doctors Sen and Samantha Pearson, a couple boasting ... chose to launch Restore My Vision Today as a ... that many ophthalmologists have become in their respective ... makes readers privy to a “secret” trove of pertinent ...
(Date:7/12/2014)... 2014 The largest pure occupational medicine ... to announce that it will be opening its fifth ... will join four Atlanta-based Nova Medical Centers’ locations. The ... Deans Bridge Road, and will be open from 8:30 ... “With Nova’s treatment philosophy of rapid return-to-work and decreased ...
(Date:7/11/2014)... DressyQuinceanera.com, a well-known wedding dress manufacturer and retailer, has ... online category. Furthermore, the firm has announced that all ... to 62% off. , The brand new Quinceanera Dama ... quality and style. All items in the new collection ... the company’s other items: lace evening dresses, short bridesmaid ...
Breaking Medicine News(10 mins):Health News:Mobile Device Forensics Guidelines Play Key Role in Supreme Court’s Smartphone Evidence Warrant Decision 2Health News:Mobile Device Forensics Guidelines Play Key Role in Supreme Court’s Smartphone Evidence Warrant Decision 3Health News:Mobile Device Forensics Guidelines Play Key Role in Supreme Court’s Smartphone Evidence Warrant Decision 4Health News:Mobile Device Forensics Guidelines Play Key Role in Supreme Court’s Smartphone Evidence Warrant Decision 5Health News:Best Summer Cosmetic Surgeries Revealed in Article By Seattle Plastic Surgeon 2Health News:Restore My Vision Today | Groundbreaking Book Reveals How To Restore Your Vision Without The Use of Glasses – Vinamy 2Health News:Restore My Vision Today | Groundbreaking Book Reveals How To Restore Your Vision Without The Use of Glasses – Vinamy 3Health News:Nova Medical Centers To Open New Facility in Augusta, Georgia 2Health News:DressyQuinceanera.com: Beautiful Quinceanera Dama Dresses At Low Prices 2
... (January 25, 2008) Research in the January issue ... (JACS) shows that many patients with minimal injuries ... and II trauma centers, despite the ability of the ... that overuse of trauma centers threatens to limit the ...
... Inc. (NYSE: WTW ) announced today that ... Sardini, Chief Financial,Officer, will present at the Credit ... The presentation will be held on Tuesday, ... a.m. local time) and will be accessible via ...
... to encourage Americans to ... 25 , Who: "The Biggest Loser" Season Four winner Bill Germanakos ... with MSN Health & Fitness and ... discuss "The Biggest Loser" Million Pound Match-Up sweepstakes, at ...
... Doctors Care is,pleased to announce the opening of its ... Hoffmeyer Road, Florence. The new center opened,January 23, 2008. ... scheduled to,open soon., Dr. Thomas Gibbons, the Midlands ... "Doctors Care is excited to provide convenient,urgent care, family ...
... 300-bed facility in Tempe, Arizona, raises MDS capacity in the ... Phoenix-area to 420 ... MDS Pharma,Services (http://www.mdsps.com ), a leading provider of innovative drug ... a new 300-bed Phase I facility in nearby Tempe, Arizona. The ...
... Md., Jan. 25 MiddleBrook,Pharmaceuticals, Inc. (Nasdaq: ... commercializing novel anti-infective products, today,announced that it has ... the private placement of 8,750,000 shares of,its common ... includes,five-year warrants to purchase 3,500,000 shares of common ...
Cached Medicine News:Health News:Excessive overtriage in US trauma centers overwhelming system resources, delaying patient care 2Health News:Weight Watchers to Present at Credit Suisse 10th Annual Global Services Conference 2Health News:Bill Germanakos and Hollie Self Bring 'The Biggest Loser' Million-Pound Tour, Presented by MSN, to Arizona Mills Mall 2Health News:UCI Medical Affiliates Inc. Opens New Doctors Care Center in Florence 2Health News:MDS Pharma Services Opens Largest Phase I Clinic on U.S. West Coast 2Health News:MiddleBrook Pharmaceuticals to Raise $21 Million Through Private Placement of Common Equity 2Health News:MiddleBrook Pharmaceuticals to Raise $21 Million Through Private Placement of Common Equity 3Health News:MiddleBrook Pharmaceuticals to Raise $21 Million Through Private Placement of Common Equity 4
(Date:7/11/2014)... 2014  Australian drug delivery company, Phosphagenics Limited (ASX: ... A$19.3 million via a placement of A$16.3 million to ... U.S., Asia and ... purchase plan (SPP) to be offered to existing shareholders. ... two tranches. "This capital raising positions us ...
(Date:7/11/2014)... July 11, 2014  Veran Medical Technologies, ... today the positive, cost-effective final results for ... procedure. The SPiNPerc endobronchial percutaneous biopsy study ... approach to biopsy when a traditional bronchoscopic ... physicians experience positive financial outcomes when more ...
(Date:7/10/2014)... NEWS, Virginia , 11. Juli ... Hersteller von Kameras für die molekulare ... (MBI/BSGI), hat heute die CE-Zulassung für ... dem CE-Zeichen kann Dilon das Produkt ... Vertriebsbereich auf den Großteil der europäischen ...
Breaking Medicine Technology:Phosphagenics' A$19.3 million Capital Raising 2Phosphagenics' A$19.3 million Capital Raising 3Veran Medical Publishes Lung Cancer Patient Management Study 2Dilon erhält CE-Zulassung für sein Navigator-Gamma-Sondensystem 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: