Navigation Links
Common Blood Pressure Drugs Might Lower Dementia Risk
Date:1/7/2013

By Kathleen Doheny
HealthDay Reporter

MONDAY, Jan. 7 (HealthDay News) -- Taking blood pressure drugs known as beta blockers may reduce the risk of brain changes that can lead to Alzheimer's disease and other dementias, new research suggests.

"Levels of the Alzheimer lesions were about half or less in persons receiving beta blockers, compared with persons whose hypertension was untreated," said study author Dr. Lon White, a researcher at the Pacific Health Research and Education Institute in Honolulu. Beta blockers also appeared to reduce the risk of these brain changes more than other blood pressure medications did.

White added a caution, however. "It would be premature to make any specific recommendations for treatment," he said, such as suggesting people switch to beta blockers only.

Examples of beta blockers are Inderal (propranolol), Tenormin (atenolol) and Lopressor (metoprolol).

"Our findings will need to be examined in other studies before such recommendations could be made," White said.

The research does support the idea that treating high blood pressure in midlife must be part of the way to prevent late-life cognitive impairment and dementia, he said.

The study is scheduled to be presented in March at the American Academy of Neurology annual meeting in San Diego.

One in eight older American adults has Alzheimer's, a progressive brain disease, according to the Alzheimer's Association. Alzheimer's and other types of dementia affect memory, thinking and behavior.

In the study, White and colleagues evaluated the autopsies of 774 men who were enrolled in the Honolulu-Asia Aging Study, a community-based study of Japanese-American men who were between the ages of 71 to 93 when the study began. The study was conducted from 1991 through 2012.

Of the men who were autopsied, 610 had had high blood pressure or had been treated with high blood pressure drugs. The men had taken five common types of blood pressure-lowering medicines. White also looked at two subgroups who took two or more medicines in combination, a common practice for lowering blood pressure.

After adjusting for factors such as the men's age, their blood pressure levels at the study's start, their test scores and other factors, White found those who took beta blockers as their only blood pressure-lowering drug had fewer brain abnormalities -- such as lesions associated with Alzheimer's -- than those who took no hypertension drugs or other types of blood pressure medications.

Those who took beta blockers in combination with other blood pressure-lowering drugs also had fewer brain abnormalities, but the benefit was not as great as in the beta blocker-alone group.

White can't explain why the beta blockers seem to have a protective effect. "We have no way to attribute the association with fewer brain lesions to any specific underlying mechanism," he said.

An Alzheimer's expert discussed the new findings.

"This is an interesting study, and the Honolulu-Asia Aging Study has been a valuable source of information," said Heather Snyder, senior associate director of medical and scientific relations for the Alzheimer's Association.

However, she added: "It's a small study. I would agree it is premature to draw conclusions about treatment."

Some people with brain lesions, one of the markers used in the study to gauge risk of Alzheimer's, do not have cognitive changes, she added.

Until more research is in, she said, those who want to reduce their risk of Alzheimer's disease should maintain a healthy cardiovascular system by eating a good diet and staying physically active.

White will continue his research. The Alzheimer's Association has given him a grant to continue the study of the brain tissue. He will examine the tissue for signs of changes known to be linked with Alzheimer's and evaluate which risk factors during life were linked with the brain abnormalities.

Research presented at medical meetings should be viewed as preliminary until published in a peer-reviewed journal.

While this study showed an association between beta blockers and a reduced risk of brain changes typical of Alzheimer's, it did not prove a cause-and-effect link.

More information

To learn more about Alzheimer's, visit the Alzheimer's Association.

SOURCES: Lon White, M.D., researcher, Pacific Health Research and Education Institute, Honolulu; Heather Snyder, Ph.D., senior associate director, medical and scientific relations, Alzheimer's Association; March 16-23, 2013, presentation, American Academy of Neurology annual meeting, San Diego


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Texting in College Classrooms Common, Distracting
2. Recovery from propofol anesthesia may be sped by use of common stimulant
3. Long-term neuropsychological impairment is common in acute lung injury survivors
4. Overuse Injuries Common Among Female College Athletes
5. Common Blood Pressure Drug Safe for Heart Failure: Study
6. Test links strains of common parasite to severe illness in US newborns
7. Common Plastics Chemical Might Boost Diabetes Risk
8. Off-Label Drug Use Appears Common
9. Global, common approach to pharmaceutical supply chain integrity the focus of workshop
10. Slow-growing babies more likely in normal-weight women; Less common in obese pregnancies
11. Common Blood Pressure Drugs May Not Cut Colon Cancer Risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Common Blood Pressure Drugs Might Lower Dementia Risk
(Date:1/16/2017)... GA (PRWEB) , ... January 16, 2017 , ... ... to announce their recent partnership with an innovator in the wheelchair accessibility industry, ... to motivate their dealer salespeople to sell wheelchair accessible vehicles. With this new ...
(Date:1/16/2017)... ... ... One thing common to all types of cancer is that it’s a ... money spent screening for and treating cancer in the United States is estimated to ... than in any other country that has an advanced healthcare system, sometimes spending as ...
(Date:1/15/2017)... ... January 15, 2017 , ... Going above and ... that strives to better communities around the world by offering the Gensuite team ... the opportunity for team members to become involved in a cause that is ...
(Date:1/15/2017)... ... 14, 2017 , ... Wondering where to go this Valentine's Day? Well, there ... for a romantic, lobster feast in the comfort of your own home. Lobster Gram ... dinners will be featured until February 15th, 2017. , Romantic Dinner one is ...
(Date:1/14/2017)... ... January 14, 2017 , ... AgileMinder develops innovative products and services ... Scale is now available on Apple as a fun, free emoji sticker pack for ... one of the ten color coded values on The Emoji Scale. , On ...
Breaking Medicine News(10 mins):
(Date:1/16/2017)... and PUNE, India , January ... by Allied Market Research, titled, "Vital Signs Monitoring Devices Market ... Forecast, 2014-2022", projects that the global vital signs monitoring devices ... expected to reach $5,491 million by 2022, growing at a ... America was the leading regional market in global ...
(Date:1/16/2017)... Oregon and PUNE, India , January 16, 2017 ... Research, titled, "Antioxidants Market by Type - Global Opportunity Analysis and Industry Forecast, ... is expected to reach $4,531 million by 2022, registering a CAGR of 6.42% ... for more than one-third share of the global volume in 2015. ... ...
(Date:1/16/2017)... 16, 2017  Dovetail Genomics today announced the commercial ... service, which yields chromosome-scale genome assemblies. The service is ... workshop on Jan. 17 at the Plant & Animal ... . "We are thrilled to be ... our Dovetail Hi-C offering," said Todd Dickinson , ...
Breaking Medicine Technology: