Navigation Links
Common Blood Pressure Drugs Might Lower Dementia Risk
Date:1/7/2013

By Kathleen Doheny
HealthDay Reporter

MONDAY, Jan. 7 (HealthDay News) -- Taking blood pressure drugs known as beta blockers may reduce the risk of brain changes that can lead to Alzheimer's disease and other dementias, new research suggests.

"Levels of the Alzheimer lesions were about half or less in persons receiving beta blockers, compared with persons whose hypertension was untreated," said study author Dr. Lon White, a researcher at the Pacific Health Research and Education Institute in Honolulu. Beta blockers also appeared to reduce the risk of these brain changes more than other blood pressure medications did.

White added a caution, however. "It would be premature to make any specific recommendations for treatment," he said, such as suggesting people switch to beta blockers only.

Examples of beta blockers are Inderal (propranolol), Tenormin (atenolol) and Lopressor (metoprolol).

"Our findings will need to be examined in other studies before such recommendations could be made," White said.

The research does support the idea that treating high blood pressure in midlife must be part of the way to prevent late-life cognitive impairment and dementia, he said.

The study is scheduled to be presented in March at the American Academy of Neurology annual meeting in San Diego.

One in eight older American adults has Alzheimer's, a progressive brain disease, according to the Alzheimer's Association. Alzheimer's and other types of dementia affect memory, thinking and behavior.

In the study, White and colleagues evaluated the autopsies of 774 men who were enrolled in the Honolulu-Asia Aging Study, a community-based study of Japanese-American men who were between the ages of 71 to 93 when the study began. The study was conducted from 1991 through 2012.

Of the men who were autopsied, 610 had had high blood pressure or had been treated with high blood pressure drugs. The men had taken five common types of blood pressure-lowering medicines. White also looked at two subgroups who took two or more medicines in combination, a common practice for lowering blood pressure.

After adjusting for factors such as the men's age, their blood pressure levels at the study's start, their test scores and other factors, White found those who took beta blockers as their only blood pressure-lowering drug had fewer brain abnormalities -- such as lesions associated with Alzheimer's -- than those who took no hypertension drugs or other types of blood pressure medications.

Those who took beta blockers in combination with other blood pressure-lowering drugs also had fewer brain abnormalities, but the benefit was not as great as in the beta blocker-alone group.

White can't explain why the beta blockers seem to have a protective effect. "We have no way to attribute the association with fewer brain lesions to any specific underlying mechanism," he said.

An Alzheimer's expert discussed the new findings.

"This is an interesting study, and the Honolulu-Asia Aging Study has been a valuable source of information," said Heather Snyder, senior associate director of medical and scientific relations for the Alzheimer's Association.

However, she added: "It's a small study. I would agree it is premature to draw conclusions about treatment."

Some people with brain lesions, one of the markers used in the study to gauge risk of Alzheimer's, do not have cognitive changes, she added.

Until more research is in, she said, those who want to reduce their risk of Alzheimer's disease should maintain a healthy cardiovascular system by eating a good diet and staying physically active.

White will continue his research. The Alzheimer's Association has given him a grant to continue the study of the brain tissue. He will examine the tissue for signs of changes known to be linked with Alzheimer's and evaluate which risk factors during life were linked with the brain abnormalities.

Research presented at medical meetings should be viewed as preliminary until published in a peer-reviewed journal.

While this study showed an association between beta blockers and a reduced risk of brain changes typical of Alzheimer's, it did not prove a cause-and-effect link.

More information

To learn more about Alzheimer's, visit the Alzheimer's Association.

SOURCES: Lon White, M.D., researcher, Pacific Health Research and Education Institute, Honolulu; Heather Snyder, Ph.D., senior associate director, medical and scientific relations, Alzheimer's Association; March 16-23, 2013, presentation, American Academy of Neurology annual meeting, San Diego


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Texting in College Classrooms Common, Distracting
2. Recovery from propofol anesthesia may be sped by use of common stimulant
3. Long-term neuropsychological impairment is common in acute lung injury survivors
4. Overuse Injuries Common Among Female College Athletes
5. Common Blood Pressure Drug Safe for Heart Failure: Study
6. Test links strains of common parasite to severe illness in US newborns
7. Common Plastics Chemical Might Boost Diabetes Risk
8. Off-Label Drug Use Appears Common
9. Global, common approach to pharmaceutical supply chain integrity the focus of workshop
10. Slow-growing babies more likely in normal-weight women; Less common in obese pregnancies
11. Common Blood Pressure Drugs May Not Cut Colon Cancer Risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Common Blood Pressure Drugs Might Lower Dementia Risk
(Date:10/13/2017)... ... , ... The American Board of Family Medicine's (ABFM) Board of Directors has ... succeeding Dr. James C. Puffer upon his retirement. Dr. Newton will serve in the ... at the end of 2018. Upon assuming the role of President and CEO on ...
(Date:10/13/2017)... ... 13, 2017 , ... Apple Rehab Shelton Lakes , which specializes in ... the facility as part of a disaster drill on October 3rd. , Apple Rehab ... City Emergency Manager, as well as the Connecticut Long Term Care Mutual Aid ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The ... the most popular and least understood books in the Holy Scriptures, Revelation. The Book ... have baffled scholars for centuries. Many have tossed it off as mere rubbish, but ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... services for healthcare compliance program management, will showcase a range of technology and ... for Assisted Living (NCAL) Convention and Expo to be held October 14–18, 2017 ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical ... Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. ... honor of Morris F. Collen, a pioneer in the field of medical informatics, this ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... , Oct. 12, 2017 AVACEN Medical , ... company with their  2017 New Product Innovation Award for ... extensive primary and secondary medical device market research by Frost ... its first-to-market OTC, drug-free pain relief product, the AVACEN 100, ... to treating fibromyalgia widespread pain. ...
(Date:10/11/2017)... Texas , Oct. 11, 2017  True ... services, has amplified its effort during National Breast ... about hereditary cancer risks. ... of Clinical Oncology calculated that more than 10 ... have inherited mutations in BRCA1 or BRCA2 and have ...
(Date:10/5/2017)... , Oct. 5, 2017  In response ... of Oral and Maxillofacial Surgeons (AAOMS) released prescribing ... – to be used as a first-line therapy ... Recognizing the ... AAOMS White Paper "Opioid Prescribing: Acute and Postoperative ...
Breaking Medicine Technology: