Navigation Links
Common Birth Defect Likely Inherited
Date:6/15/2010

Pyloric stenosis renders babies unable to pass food through intestine, researchers explain

TUESDAY, June 15 (HealthDay News) -- A severe and potentially deadly digestive tract disorder in infants may have a genetic component, finds a new study from Denmark.

Pyloric stenosis, a birth defect that typically affects infants two to eight weeks old, involves an inability to pass food from the stomach into the duodenum, part of the small intestine. The condition is the most common reason for surgery in the first months of life. Among whites, there are 1.5 to 3 cases of pyloric stenosis per 1,000 live births.

This study of nearly two million children born in Denmark between 1977 and 2008 found that pyloric stenosis is more common among twins and siblings. During the study period, 3,362 of the children had surgery for the birth defect. The researchers found that 46 percent of children with an affected identical (monozygotic) twin and 7.7 percent of children with an affected fraternal (dizygotic) twin also had pyloric stenosis.

The findings highlight a strong family risk of pyloric stenosis, with a nearly 200-fold increased risk among identical twins and a 20-fold increase among siblings. Even more distant relatives had an increased risk, the researchers said.

"Our findings argue for a hereditary component of pyloric stenosis," wrote Dr. Camilla Krogh, of the Statens Serum Institute in Copenhagen, and colleagues, in a news release. Not only was it predominant in boys, the risk was higher among identical twins and fraternal twins and cropped up among even third-degree relatives. There was a difference in risk between siblings and half-siblings (and cousins and half-cousins), and there was "a heritability [estimate] of 87 percent," whose most likely explanation was shared genes that affected individuals' responses to various factors after birth, Krogh noted.

The researchers conclude that "the high rates for twins and siblings should be considered in counseling families with affected children."

The study appears in the June 16 issue of the Journal of the American Medical Association.

More information

The Nemours Foundation has more about pyloric stenosis.



-- Robert Preidt



SOURCE: Journal of the American Medical Association, June 16, 2010, news release.


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Ear Infection is the Most Common Reason Why an American Child Sees the Doctor
2. Common Alzheimers medication helps skills necessary for safe driving
3. Video study finds risky food-safety behavior more common than thought
4. Sleep-disordered breathing is common but hard to detect in pediatric patients
5. Hip exercises found effective at reducing, eliminating common knee pain in runners
6. Jews Around the World Linked by Common Genetic Ancestry
7. Share Your Walls, Not the Noise. Introducing dB-Bloc for Common Wall Sound Bleed
8. Common Diabetes Drug Linked to Vitamin B-12 Deficiency
9. Study: Yogurt-like drink DanActive reduced rate of common infections in daycare children
10. Mayo Clinic researchers find genetic secrets to common kidney cancer
11. Treating Common Irregular Heartbeat Might Also Ward Off Alzheimers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Common Birth Defect Likely Inherited
(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term insurance that ... insurance companies have a waiver for care if the client has a cognitive impairment ... family pays for care, is often waived, so the benefits from their insurance start ...
(Date:10/13/2017)... ... ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, has released ... understood books in the Holy Scriptures, Revelation. The Book of Revelation paints a picture ... Many have tossed it off as mere rubbish, but Yisrayl Hawkins says that is ...
(Date:10/13/2017)... ... ... On The Brink”: the Christian history of the United States and the loss of ... William Nowers. Captain Nowers and his wife, Millie, have six children, ten grandchildren, ... Navy. Following his career as a naval aviator and carrier pilot, he spent ...
(Date:10/12/2017)... ... October 12, 2017 , ... The company has developed a ... and regulatory authorities worldwide. From Children’s to Adults 50+, every formula has been ... standard. , These products are also: Gluten Free, Non-GMO, Vegan, Soy Free, ...
(Date:10/12/2017)... ... October 12, 2017 , ... Information about the ... to develop to enable prevention of a major side effect of chemotherapy in ... in pediatric patients. For cisplatin, hearing loss is FDA listed on-label as a ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... the Centers for Disease Control and Prevention (CDC), influenza vaccination should ... helping communities across Massachusetts , Connecticut ... shots through the end of the month. *Some exclusions apply ... ... is by the end of October, according to the Centers for Disease ...
(Date:10/2/2017)... , Oct. 2, 2017  Eli Lilly and ... financial results for the third quarter of 2017 on ... conference call on that day with the investment community ... The conference call will begin at 9 ... can access a live webcast of the conference call ...
(Date:10/2/2017)... Oct. 2, 2017 The Rebound mobile app is ... to reverse the tide of prescription drug addiction. The app ... medicine intake and stepping down their dosage in a safe, ... in December 2017; the first 100,000 people to sign up ... http://www.rebound-solution.com/ ...
Breaking Medicine Technology: