Navigation Links
Common Birth Defect Likely Inherited
Date:6/15/2010

Pyloric stenosis renders babies unable to pass food through intestine, researchers explain

TUESDAY, June 15 (HealthDay News) -- A severe and potentially deadly digestive tract disorder in infants may have a genetic component, finds a new study from Denmark.

Pyloric stenosis, a birth defect that typically affects infants two to eight weeks old, involves an inability to pass food from the stomach into the duodenum, part of the small intestine. The condition is the most common reason for surgery in the first months of life. Among whites, there are 1.5 to 3 cases of pyloric stenosis per 1,000 live births.

This study of nearly two million children born in Denmark between 1977 and 2008 found that pyloric stenosis is more common among twins and siblings. During the study period, 3,362 of the children had surgery for the birth defect. The researchers found that 46 percent of children with an affected identical (monozygotic) twin and 7.7 percent of children with an affected fraternal (dizygotic) twin also had pyloric stenosis.

The findings highlight a strong family risk of pyloric stenosis, with a nearly 200-fold increased risk among identical twins and a 20-fold increase among siblings. Even more distant relatives had an increased risk, the researchers said.

"Our findings argue for a hereditary component of pyloric stenosis," wrote Dr. Camilla Krogh, of the Statens Serum Institute in Copenhagen, and colleagues, in a news release. Not only was it predominant in boys, the risk was higher among identical twins and fraternal twins and cropped up among even third-degree relatives. There was a difference in risk between siblings and half-siblings (and cousins and half-cousins), and there was "a heritability [estimate] of 87 percent," whose most likely explanation was shared genes that affected individuals' responses to various factors after birth, Krogh noted.

The researchers conclude that "the high rates for twins and siblings should be considered in counseling families with affected children."

The study appears in the June 16 issue of the Journal of the American Medical Association.

More information

The Nemours Foundation has more about pyloric stenosis.



-- Robert Preidt



SOURCE: Journal of the American Medical Association, June 16, 2010, news release.


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Ear Infection is the Most Common Reason Why an American Child Sees the Doctor
2. Common Alzheimers medication helps skills necessary for safe driving
3. Video study finds risky food-safety behavior more common than thought
4. Sleep-disordered breathing is common but hard to detect in pediatric patients
5. Hip exercises found effective at reducing, eliminating common knee pain in runners
6. Jews Around the World Linked by Common Genetic Ancestry
7. Share Your Walls, Not the Noise. Introducing dB-Bloc for Common Wall Sound Bleed
8. Common Diabetes Drug Linked to Vitamin B-12 Deficiency
9. Study: Yogurt-like drink DanActive reduced rate of common infections in daycare children
10. Mayo Clinic researchers find genetic secrets to common kidney cancer
11. Treating Common Irregular Heartbeat Might Also Ward Off Alzheimers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Common Birth Defect Likely Inherited
(Date:10/13/2017)... BASKING RIDGE, N.J. (PRWEB) , ... October 13, 2017 , ... ... second annual Holly Day Market. Featuring a collection of specialty vendors and unique items ... myriad of personalized and quality-focused health and wellness services offered by the VNA. ...
(Date:10/13/2017)... ... 13, 2017 , ... Coveros, a leader in agile coaching ... contract by the Center for Medicare and Medicaid Services (CMS). The Enterprise Agile ... of Agile methodologies in a consistent and high value manner across CMS programs. ...
(Date:10/12/2017)... ... , ... Planet Fitness, one of the largest and fastest growing franchisors and ... flagship location in Covington, LA at 401 N. U.S. Highway 190, in January of ... Depot in the Holiday Square shopping center. Its location allows it to serve both ...
(Date:10/12/2017)... Rockville, Maryland (PRWEB) , ... October 12, 2017 ... ... a magnetic drug delivery system that we intend to develop to enable prevention ... regimens can lead to severe hearing loss, especially in pediatric patients. For cisplatin, ...
(Date:10/12/2017)... ... October 12, 2017 , ... Women-owned and ... 2017 Best and Brightest in Wellness® by Best and Brightest. OnSite Wellness will ... Friday, Oct. 20 from 7:30 a.m. to 2 p.m. at the Henry Autograph ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... Pa. , Oct. 12, 2017 ... leader in innovative solutions for injectable drug administration, today ... before the market opens on Thursday, October 26, 2017, ... the results and business expectations at 9:00 a.m. Eastern ... (U.S.) or 253-336-8738 (International). The conference ID is 94093362. ...
(Date:10/11/2017)...  Caris Life Sciences ® , a leading innovator ... precision medicine, today announced that St. Jude Medical Center,s ... (POA) as its 17 th member. Through participation ... Cancer Institute will help develop standards of care and ... making cancer treatment more precise and effective. ...
(Date:10/11/2017)... 2017  Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today ... Las Piedras, Puerto Rico , where ... Following a comprehensive ... minor structural damage, temporary loss of power and minimal ... completed, manufacturing operations have resumed, and the company expects ...
Breaking Medicine Technology: