Navigation Links
Common Antidepressants Tied to Higher Bleeding Risk in Warfarin Users: Study
Date:11/8/2012

By E.J. Mundell
HealthDay Reporter

THURSDAY, Nov. 8 (HealthDay News) -- Millions of older Americans take the blood thinner warfarin, and many may also take one of a widely used class of antidepressants called SSRIs.

Now, a new study finds that selective serotonin reuptake inhibitors (SSRIs) -- which include Celexa, Paxil, Prozac and Zoloft -- may raise the risk for major bleeding in patients also taking warfarin.

Still, because depression is such a tough-to-treat illness, experts say the finding is no reason for patients on warfarin to immediately drop their SSRI.

"The most important thing would be to talk to their doctor, and perhaps for patients who are on both of these medicines, doctors should just keep a close eye on them," said study author Gene Quinn, who was a resident physician in internal medicine at the University of California, San Francisco, at the time of the study.

He presented the finding this week at the American Heart Association annual meeting, in Los Angeles.

Warfarin has been prescribed for decades to help prevent stroke. According to Quinn, smaller, less rigorous studies have suggested that SSRI antidepressants might interact with warfarin to boost bleeding risks, but those studies hadn't taken other factors, such as a patient's age or level of illness, into account.

In the new study, Quinn and his colleagues took those factors into account while looking at data from an ongoing study of more than 13,000 people with the irregular heartbeat known as atrial fibrillation. Almost 9,200 of the patients were also taking warfarin, and this subset was the focus of the new study.

According to Quinn, the warfarin users were divided into three groups: "Patients who were taking no antidepressants, patients who were taking SSRIs and patients who were taking [older] tricyclic antidepressants."

Comparing the bleeding risks among the three groups, "we found that there was a 60 percent higher risk of major hemorrhage in patients that were taking SSRIs and warfarin," versus those who weren't taking an SSRI.

What's more, "there was actually no statistically significant difference [in risk] in those patients taking tricyclic antidepressants and warfarin," Quinn said. That means that the effect was for "SSRIs specifically, not all antidepressants."

Still, Quinn cautioned that the finding remains an association only, and the study could not prove that SSRI use actually helped to cause the bleeds.

He also stressed that the absolute risk to any one patient taking both warfarin and an SSRI remains low. According to the data, Quinn said, "if I took 100 people and treated them with warfarin for one year each, there would be 1.3 hemorrhages, whereas on SSRIs there would be 2.3 hemorrhages out of those 100 people."

He said it's not clear how SSRI medications might encourage bleeding, although experts do have theories. "There have been other studies that platelet aggregation [clotting] and the platelet's ability to clot is related to serotonin, so blocking the serotonin may not allow them to clot as well anymore," Quinn said.

One psychiatrist said there's no reason for a person taking both warfarin and an SSRI antidepressant to worry at this point.

"It does not appear necessary to avoid using SSRIs or other antidepressants in people taking warfarin, but the possibility of increased bleeding risk should be considered when selecting treatment for depression," advised Dr. Bryan Bruno, acting chairman of the department of psychiatry at Lenox Hill Hospital in New York City.

He believes that if an antidepressant "is added to warfarin therapy, the patient needs to be monitored closely for evidence of bleeding, especially during the first two or three months of antidepressant therapy."

Quinn agreed. "Depression is a big deal and we don't want patients to go untreated just because of a worry for this," he said.

Findings presented at medical meetings are typically considered preliminary until published in a peer-reviewed journal.

More information

To find out more about how to safely use blood thinners, head to the Agency for Healthcare Research and Quality.

SOURCES: Gene Quinn, M.D., (former) resident physician in internal medicine, University of California, San Francisco; Bryan Bruno, M.D., acting chairman, department of psychiatry, Lenox Hill Hospital, New York City; Nov 5, 2012, presentation, American Heart Association annual meeting, Los Angeles


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Texting in College Classrooms Common, Distracting
2. Recovery from propofol anesthesia may be sped by use of common stimulant
3. Long-term neuropsychological impairment is common in acute lung injury survivors
4. Overuse Injuries Common Among Female College Athletes
5. Common Blood Pressure Drug Safe for Heart Failure: Study
6. Test links strains of common parasite to severe illness in US newborns
7. Common Plastics Chemical Might Boost Diabetes Risk
8. Off-Label Drug Use Appears Common
9. Global, common approach to pharmaceutical supply chain integrity the focus of workshop
10. Slow-growing babies more likely in normal-weight women; Less common in obese pregnancies
11. Common Blood Pressure Drugs May Not Cut Colon Cancer Risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Common Antidepressants Tied to Higher Bleeding Risk in Warfarin Users: Study
(Date:6/27/2016)... ... June 27, 2016 , ... TopConsumerReviews.com recently awarded their ... Eyeglasses . , Millions of individuals in the United States and Canada wear eyeglasses. ... way to both correct vision and make a fashion statement. Even celebrities use glasses ...
(Date:6/26/2016)... ... 2016 , ... PawPaws brand pet supplements owned by Whole Health ... the health of felines. The formula is all-natural and is made from Chinese herbs ... Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract and Rehmannia ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery services, can now ... and to Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings ... The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under the ...
(Date:6/25/2016)... CA (PRWEB) , ... June 25, 2016 , ... As ... with Magna Cum Laude and his M.D from the David Geffen School of Medicine ... and returned to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive ...
(Date:6/24/2016)... ... 24, 2016 , ... A recent article published June 14 on ... article goes on to state that individuals are now more comfortable seeking to undergo ... such as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016 ... the addition of the " Global Markets for ... This report focuses on ... updated review, including its applications in various applications. The ... which includes three main industries: pharmaceutical and biotechnology, food ...
(Date:6/24/2016)... 24, 2016 Dehaier Medical Systems Ltd. (NASDAQ: ... develops, markets and sells medical devices and wearable sleep ... a strategic cooperation agreement with Hongyuan Supply Chain Management ... on June 20, 2016, to develop Dehaier,s new Internet ... agreement, Dehaier will leverage Hongyuan Supply Chain,s sales platform ...
(Date:6/24/2016)... -- According to a new market research ... Safety Pen Needles), Needle Length (4mm, 5mm, 6mm, 8mm, ... Purchase (Retail, Non-Retail) - Trends & Global Forecasts to ... for the forecast period of 2016 to 2021. This ... 2021 from USD 1.65 Billion in 2016, growing at ...
Breaking Medicine Technology: