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Coming soon: Cell therapies for diabetes, cancer?
Date:3/19/2008

y treated, if a single cancer stem cell remains cancer, could spread and form new tumors.

Also, it appears that cancer stem cells have the ability to repair DNA damage more effectively than do cancer cells, thus adding to a tumors drug resistance. Thus, treatment strategies based on the existence of cancer stem cells - which are reported to be resistant to standard anti-cancer drugs - may take a leap forward when stem cells can be targeted.

A further question arises as to whether only cancer stem cells can be targeted without damaging normal stem cells, added Dr. Kobayashi.

Artificial cells

Although human adult stem cells are ideal for cell therapy via transplantation, keeping available cells alive over the long term is difficult.

We are making efforts to economically establish reversible immortalized human cell lines that can be grown in tissue cultures and used for future gene transfers, explained Dr. Kobayashi. Achieving immortalization, a two-stage process, is not without challenges.

According to Dr. Kobayashi, research focusing on reversible immortalization is being carried out to make safe and secure cell lines with the immortalization gene able to be removed once cell proliferation has been achieved.


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Contact: Naoya Kobayashi
immortal@md.okayama-u.ac.jp
81-862-357-485
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

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