Navigation Links
Coming Soon: Lung-Cancer Spray?
Date:6/15/2009

Novel delivery of gene therapy suppresses tumors in mice

MONDAY, June 15 (HealthDay News) -- Scientists may someday be able to fight lung cancer using gene therapy delivered by an inhalable spray.

In a new study, mice with lung cancer that were treated with a vaporized viral vector twice a week for four weeks had fewer, smaller tumors than untreated mice.

Researchers also found that treated mice had increased apoptosis, or programmed cell death, necessary for healthy tissues, as well as suppressed production of several proteins that contribute to cancer cell growth.

The study, by researchers at Seoul National University in Korea, appears in the June 15 issue of the American Journal of Respiratory and Critical Care Medicine.

"Aerosol delivery targets the lungs specifically and represents a noninvasive alternative for targeting genes to the lung," wrote study author Myung-Haing Cho, a professor at Seoul National University. "The delivery of genes via aerosol holds promise for the treatment of a broad spectrum of pulmonary disorders and offers numerous advantages over more invasive modes of delivery."

In the study, researchers used a lentiviral vector derived from a retrovirus able to infect non-dividing cells, causing lasting genetic changes. The lentiviral vector included a carboxyl-terminal modulator protein (CTMP), which inhibits Akt signaling.

Previous research has shown 90 percent of non-small cell lung carcinomas involve the Akt signaling pathway, according to the study.

Researchers divided mice into three groups: one received the aerosolized CTMP vector, one received the vector alone and one third were untreated.

The mice treated by the CTMP vector had significantly fewer, smaller tumors.

Globally, lung cancer is the most common cause of cancer deaths. Most treatments, including surgery, radiation and chemotherapy, slow progression of the disease only temporarily.

While much research is underway on the use of gene therapy to treat lung cancer, one stumbling block has been finding delivery mechanisms that work.

"Our results demonstrated that lentivirus-mediated CTMP overexpression suppressed Akt activity and inhibited tumor progression," Cho wrote.

More information

The National Cancer Institute has more on lung cancer.



-- Jennifer Thomas



SOURCE: American Journal of Respiratory and Critical Care Medicine, news release, June 15, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Digital TV Transition Coming Soon; Update Preparedness Plans
2. Kendle to Present at Upcoming Jefferies and Wachovia Securities Conferences
3. Align Technology Executive to Present at Upcoming Financial Conference
4. Upcoming Investor Events at The American Association for Clinical Chemistry (AACC) Annual Meeting & Clinical Lab Exposition
5. Almost Family to Present at Two Upcoming Conferences
6. B. Braun Anticipates Becoming First to Deliver FDA Approved 2g Cefazolin
7. drugstore.com, inc. to Present at Upcoming Financial Conferences
8. WellPoint Announces Appearances at Upcoming Conferences
9. ResMed Inc. to Present at Upcoming Conferences in June
10. Finding a New Doctor Becoming More Difficult for Medicare Recipients Says MedicareSupplementPlans.com
11. Medivation Announces Upcoming Presentation of New MDV3100 Data in Patients With Advanced Prostate Cancer at 45th American Society of Clinical Oncology Annual Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Coming Soon:  Lung-Cancer Spray?
(Date:6/28/2017)... ... June 28, 2017 , ... Eating disorders have the highest mortality rate ... least one person dies as a direct result from an eating disorder in the ... treatment providers. The iaedp Foundation meets this challenge by offering what has become the ...
(Date:6/28/2017)... Clara, CA (PRWEB) , ... June 28, 2017 , ... ... hosting a free AFM Luncheon for all SEMICONWest attendees and Park customers ... luncheon will feature talks from Dr. Sang-il Park, Chairman & CEO of Park Systems, ...
(Date:6/28/2017)... ... 2017 , ... Designers Insurance Agency, a privately owned firm ... DC, is announcing a cooperative charity event in conjunction with the Insight Memory ... lead to memory impairment. , The Insight Memory Care Center (IMCC) offers a ...
(Date:6/27/2017)... and London UK (PRWEB) , ... June 27, 2017 , ... ... to a clinical study is whether they can trust the sponsor to pay them ... is vital that sponsors and CROs establish payment strategies that encourage sites to work ...
(Date:6/27/2017)... ... June 27, 2017 , ... ... SUNucate efforts, Louisiana became the sixth state to pass legislation which ensures ... John Bel Edwards’ signature, Louisiana joins the states of Alabama, Arizona, Florida, Utah ...
Breaking Medicine News(10 mins):
(Date:5/30/2017)... DarioHealth Corp. (NASDAQ: DRIO), a leading global digital health company with ... be presenting at the 7th annual LD Micro Invitational on Tuesday, ... CEO, of DarioHealth will be giving the presentation and meeting with ... & 7th, 2017 at the Luxe Sunset Bel Air Hotel and ... About LD Micro LD Micro was ...
(Date:5/29/2017)...  Cellect Biotechnology Ltd. (NASDAQ: APOP ; TASE: ... functional selection of stem cells, today provided a corporate ... ended March 31 st , 2017. ... first quarter of 2017," said Dr. Shai Yarkoni, Chief ... treatment of the first blood cancer patient in the ...
(Date:5/24/2017)...  ivWatch LLC today announced the launch of ... enable seamless integration of ivWatch,s groundbreaking IV infiltration ... and other devices. By integrating ivWatch technology into ... health care customers deliver a higher level of ... therapy. "The ivWatch OEM Board provides ...
Breaking Medicine Technology: