Navigation Links
Combo of Tests Might Spot Ovarian Cancer Early
Date:3/10/2009

Preliminary findings offer hope against a silent killer,,

TUESDAY, March 10 (HealthDay News) -- Used together, a blood test and an ultrasound scan may be effective in detecting ovarian cancer in its early and more curable stages, British researchers report.

The two-step detection method could become a new standard in the fight against this deadly and hard to spot malignancy, experts say.

"It appears to be an approach that may be workable," said Robert Smith, director of cancer screening at the American Cancer Society.

The report was published in the March 10 online edition of The Lancet Oncology.

Experts note that, when found early, ovarian cancer is 90 percent curable. But early detection is often impossible, because the disease causes few or no symptoms as it begins. For that reason, 70 percent of cases of ovarian cancer are diagnosed when the cancer has already reached an advanced stage.

In these later stages, the survival rate drops to only 20 percent to 30 percent. For that reason, scientists and doctors have long sought an effective early screening test.

The new study was led by Dr. Usha Menon, head of the Gynaecological Cancer Research Unit at University College London. The team randomly assigned almost 203,000 postmenopausal women to either no ovarian cancer screening or to screening with transvaginal ultrasound plus a blood test that finds a marker for ovarian cancer, called CA125. A third group was screened using transvaginal ultrasound alone.

Between 2001 and 2005, the researchers uncovered 87 ovarian cancers. The specificity of the tests was best in the combined screening group. In that cohort, fewer retests were needed and almost ninefold fewer surgeries were required, the researchers noted.

The team found that screening was able to identify most women with cervical cancer. The combination of the blood test and ultrasound found 90 percent of the cancers, while ultrasound alone found 75 percent of the cancers.

Almost 50 percent of all the cancers found were in an early stage (stage I or II), the researchers noted. And 48 percent of the more invasive ovarian cancers detected were designated as being stage I tumors. Usually, only 28 percent of ovarian cancers are identified in this early stage, the researchers pointed out.

To see whether these screening strategies have an impact on mortality, the women will continue to be screened through 2012 and followed until the end of 2014, the researchers said.

Menon stressed that it's too early to make firm recommendations based on these early findings.

"Preliminary results are encouraging," she said. "Both types of screening can be used on a large scale, and both successfully pick up ovarian cancers. But for a final answer as to whether ovarian cancer screening will save lives, we need to wait till 2015, when the trial will be finished."

For his part, the ACS' Smith said that experts have learned to be cautious when it comes to advocating a particular screening method for ovarian cancer.

"What we have is a long line of disappointing findings using either CA125 alone or ultrasound alone," he explained. But he added that, "in combination, the performance appears to be much better."

Although some women are getting these tests in the United States, women should not be asking to get these tests based on this preliminary data, Smith said. "Right now, the only group of women that is recommended to undergo any testing for ovarian cancer are women who are at very high risk due to family history," he said.

"This screening trial is both a test of whether we can actually deliver these tests and whether we have shown better survival. But more importantly, have we shown that there is a lower rate of ovarian cancer deaths?" Smith said.

More information

For more about ovarian cancer, visit the American Cancer Society.



SOURCES: Usha Menon, M.D., head, Gynaecological Cancer Research Unit, University College London, U.K.; Robert Smith, Ph.D., director, cancer screening, American Cancer Society, Atlanta; March 10, 2009, The Lancet Oncology, online


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Radiation and drug combo helps boost efficacy of lung cancer treatment
2. Aerobic, Weight Training Combo Best Against Diabetes
3. New antibiotic drug combo to speed up treatment of tuberculosis
4. Drug Combo Helps Fight Marfan Syndrome
5. Drug Combo Blocks Pain Without Impairing Movement
6. Two-Drug Combo Fights Brain Tumors
7. CPR, Defibrillator Combo Boosts Cardiac Incident Survival
8. Drug Combo Boosts Multiple Myeloma Survival
9. Drug Combos Effective Against Rheumatoid Arthritis
10. Combo PET/CT Scan Helps Spot Breast Cancers Spread
11. Drug Combo With Antibiotic May Slow MS Progression
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Combo of Tests Might Spot Ovarian Cancer Early
(Date:6/26/2016)... North Carolina (PRWEB) , ... June 26, 2016 , ... ... release of a new product that was developed to enhance the health of felines. ... for centuries. , The two main herbs in the PawPaws Cat Kidney Support ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs ... College of Mohs Surgery and to Dr. Russell Peckham for medical and surgical dermatology. ... treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar ... M.D from the David Geffen School of Medicine at UCLA. He trained in Internal ... complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had ...
(Date:6/24/2016)... ... , ... A recent article published June 14 on E Online ... on to state that individuals are now more comfortable seeking to undergo not only ... calf and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians (BHP) ...
(Date:6/24/2016)... ... 24, 2016 , ... The Pulmonary Hypertension Association (PHA) learned ... receive two significant new grants to support its work to advance research and ... by recognizing patients, medical professionals and scientists for their work in fighting pulmonary ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Research and Markets has announced the addition of the ... to 2022" report to their offering. ... financial data derived from varied research sources to present unique ... on the market during the next five years, including a ... markets, regional and country level analysis. The report provides a ...
(Date:6/23/2016)... -- Bracket , a leading clinical trial technology and ... platform, Bracket eCOA (SM) 6.0, at the 52 nd ... 2016 in Philadelphia , Pennsylvania.  A demonstration ... of its kind to fully integrate with RTSM, will be ... is a flexible platform for electronic clinical outcomes assessments that ...
(Date:6/23/2016)... and BOGOTA, Colombia , June 23, 2016  Astellas today announced the establishment of ... Farma Brasil as the company,s second affiliate in Latin America . ... ... Manager of Astellas Farma Colombia ... ...
Breaking Medicine Technology: