Navigation Links
Combo of Avastin, second drug shows promise fighting brain cancer, Mayo Clinic finds
Date:2/14/2013

nk"href="http://www.mayoclinic.org/rochester/">Minnesota.

The research began after Dr. Anastasiadis, a basic scientist who studies cell adhesion and migration, gave a seminar to a group of oncologists who treat brain tumors. The issue of bevacizumab-induced invasion was brought up and a collaboration to study it was quickly set up and funded by the Mayo Clinic Specialized Program of Research Excellence (SPORE) grant for brain cancer, one of only four in the country.

The issue of bevacizumab's induced aggressiveness is not limited to brain cancer, Dr. Anastasiadis says.

"While Avastin offers clear benefit in some patients, oncologists have noted that when cancers of many types recur after use of Avastin, they become aggressive and invasive," he says.

The team discovered that as brain tumors become more aggressive after use of bevacizumab in mice, the cancers begin inducing a family of kinases known as Src, which then activate proteins found at the edge of brain tumors. These proteins essentially give the tumor cells "legs" upon which to crawl away and find a new source of nutrition, Dr. Anastasiadis says.

"Anti-angiogenesis drugs like Avastin deprive tumor cells of blood nutrients, so the tumors shrink initially, but we believe that this deprivation acts like a switch to turn on proteins that help the cancer cells migrate to other parts of the brain in search of blood," he says. "In short, if Avastin does not allow a tumor to make new blood vessels to feed it, the tumor will move to other existing blood vessels."

The researchers then tested dasatinib, a drug that inhibits Src kinases. They found that while use of bevacizumab or dasatinib alone did not provide much benefit in mouse models of human glioblastoma, use of both together shrank tumors and blocked any subsequent spread.

"If you blo
'/>"/>

Contact: Kevin Punsky
punsky.kevin@mayo.edu
904-953-2299
Mayo Clinic
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New screening approach identified potential drug combos for difficult-to-treat melanomas
2. Combo Therapy May Help Ease Sleep Apnea at High Altitude
3. HIV Drug Combo May Help Prevent Malaria Reinfection
4. Being neurotic, and conscientious, a good combo for health
5. PI3-kinase and PARP inhibitor combo may offer new treatment option for triple-neg breast cancers
6. Cooking-Oil Combo May Improve Blood Pressure
7. Double drug combo could shut down abnormal blood vessel growth that feeds disease
8. Drug combo better for common type of metastatic breast cancer, UCI-led study finds
9. Booze, Energy Drinks, Casual Sex Combo Common in College: Study
10. FDA Approves Combo Shot for Meningitis, Hib in Kids
11. Combo Therapy May Help Ease Ringing in the Ears
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... Hudson County, NJ (PRWEB) July 31, 2014 ... that a leading gastroenterologist, Dr. Masood Rizvi, has ... system welcomes Dr. Rizvi to the community. Hundreds ... Health Medical Group, a comprehensive network of top ... wide range of specialties. This latest acquisition represents ...
(Date:7/31/2014)... You’re having a wonderful summer—sunning, gardening, enjoying BBQs ... chills and fever, headache, stiff neck, achey joints, and a ... it could actually be the first sign of Lyme ... is greater than you might think. Until last year, it ... U.S. annually. But the Centers for Disease Control and Prevention ...
(Date:7/31/2014)... 31, 2014 Two years in the ... in-depth overview of the research behind the latest scientific ... Davis and Vesanto Melina, well-respected authorities on plant-based nutrition, ... are safe and adequate for people at all stages ... as athletes and pregnant or lactating women. , ...
(Date:7/31/2014)... 31, 2014 Most mommy blogs are ... main purpose is to attract all mothers from all ... a particular group; whether its high fashion or child ... that everything on the Internet was so segmented. “I ... a particular topic and then search Google to get ...
(Date:7/31/2014)... Many black women put concerns about their hair above ... by the U.S. Centers for Disease Control and Prevention ... United States are overweight or obese. Yet some of ... have their hair restyled or restraightened, the University of ... researchers also noted a shift toward more "low-maintenance" hairstyles, ...
Breaking Medicine News(10 mins):Health News:Dr. Rizvi Joins CarePoint Health Medical Group 2Health News:Feel Like You Have A Summertime 'Flu'? It Could Be Lyme Disease 2Health News:Feel Like You Have A Summertime 'Flu'? It Could Be Lyme Disease 3Health News:New Book Presents Health Professionals With A Fully-Referenced, Meticulous Overview of the Research on Plant-Based Diets As A Healthy Choice 2Health News:New Book Presents Health Professionals With A Fully-Referenced, Meticulous Overview of the Research on Plant-Based Diets As A Healthy Choice 3Health News:Mommylish Launches Its Website 2Health News:Hairdo Trumps Exercise for Many Black Women, Study Finds 2
... ... 18 million Americans suffer from heavy snoring, but don’t realize it,s likely a tell-tale sign ... ... Americans suffer from heavy snoring, but don’t realize it may actually be a tell-tale sign ...
... 16 The 15th Annual National Ergonomics Conference ... - 20, will focus on the importance of workplace ergonomics ... topics of return on investment, the aging workforce, and safety ... offices and call centers, industrial, lab, healthcare, and uncontrolled environments ...
... It was found less effective than extended-release niacin, or ... new study raises more questions about ezetimibe (Zetia), a ... statins to lower LDL, or "bad," cholesterol. , The ... June after it was discovered that LDL-cholesterol-lowering Zetia was ...
... modern medicine finds a way to treat a medical condition, ... also have to find ways to get that treatment into ... research from North Carolina State University shows that much more ... hemophilia patients in the developing world, and that the current ...
... SINGAPORE, Nov. 16 /PRNewswire-Asia/ -- Retail sales ... in the first half of 2009 with,total consumption peaking in ... Contact Lens manufacturers. Positive sales,data showing a growth of 14% ... economic recovery that is being led by consumers spending. , ...
... of ketamine users has been published online today in ... Special K) use increasing faster than any other drug ... showing the consequences of repeated ketamine use provides valuable ... the study, researchers from University College London followed 150 ...
Cached Medicine News:Health News:Heavy Snoring Linked To Potentially Life-Threatening Conditions 2Health News:Heavy Snoring Linked To Potentially Life-Threatening Conditions 3Health News:2009 National Ergonomics Conference Opens in Las Vegas November 17 With Hundreds of Industry Leaders in Attendance 2Health News:Study Raises New Questions About Cholesterol Drug Zetia 2Health News:Study Raises New Questions About Cholesterol Drug Zetia 3Health News:Research highlights need to address hemophilia in developing world 2Health News:GfK Asia Reports: Malaysian Contact Lens Market Sees Strong Recovery in Second Half of 2009 2Health News:GfK Asia Reports: Malaysian Contact Lens Market Sees Strong Recovery in Second Half of 2009 3Health News:First ever large-scale study of ketamine users published 2
(Date:7/31/2014)... --  Auxilium Pharmaceuticals , Inc. (NASDAQ: AUXL ... that the Company will release results for the second ... the opening of the U.S. financial markets. The Company ... 8:30 a.m. ET to discuss results and highlights of ... be used during the call will be available on ...
(Date:7/31/2014)... , July 31, 2014  Decision Resources Group ... market intelligence product Marketrack to now include ChinaTrack; the ... device landscape in an interactive dashboard providing detailed brand-level ... volumes at a hospital level. Other key ... Updated data feed: In addition to end-user surveys of ...
(Date:7/31/2014)... 31, 2014 Hovione today announced that ... has successfully passed a pre-approval inspection by the US Food ... by the FDA Consumer Safety Officer, Ms. Britanny Terhar ... st July and concluded on the 25 th . ... principles and guidelines of Good Manufacturing Practices (GMP) and no ...
Breaking Medicine Technology:Auxilium Pharmaceuticals, Inc. To Announce Second Quarter 2014 Results On August 7, 2014 2Auxilium Pharmaceuticals, Inc. To Announce Second Quarter 2014 Results On August 7, 2014 3Decision Resources Group Announces First Medical Device Account Targeting Tool in China 2Successful FDA Inspection at Hovione's API Manufacturing Plant in Cork, Ireland 2
... Pharmaceuticals, Inc. (NASDAQ: AVNR ) today announced ... vice president and chief commercial officer. Mr. Palekar will be ... "Rohan has an outstanding track record of success in ... CEO of Avanir. "I am delighted that we were able ...
... On March 8, attorneys at the Arizona law firm ... for failure to pay its employees the overtime wages to ... (FLSA). The Complaint was filed in the United States District Court ... pharmaceutical reps employed in the U.S. from March 2009 until ...
Cached Medicine Technology:Avanir Pharmaceuticals Announces Appointment of Rohan Palekar as Chief Commercial Officer 2Avanir Pharmaceuticals Announces Appointment of Rohan Palekar as Chief Commercial Officer 3JacksonWhite Files Overtime Lawsuit Against Sunovion Pharmaceuticals 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: