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Combo hormone therapy has increased breast cancer risk over estrogen alone
Date:11/18/2011

on the breast and that women on the combination therapy had more breast tenderness than women on estrogen alone. What was surprising, Crandall said, was that women taking estrogen alone did have breast tenderness, but that didn't correlate to increased risk of breast cancer.

"It's intriguing to think the same symptom in two sets of women taking different hormone therapies could mean something different," Crandall said.

For this prospective study, Crandall and her team analyzed data from more than 27,337 women enrolled in the Women's Health Initiative (WHI). Of the 27,337 women, 16,608 were on the combination therapy, while 10,739 were taking estrogen alone. Launched in 1991, the WHI consisted of a set of clinical trials and an observational study involving161,808 healthy, postmenopausal women.

"These findings highlight the complexity inherent in the use of surrogate risk markers to assess menopausal hormone therapy-associated breast cancer risk," the study states.


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Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles Health Sciences
Source:Eurekalert

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