Navigation Links
Combo Treatment for Aggressive Brain Tumor May Lengthen Life
Date:3/9/2009

Study finds longer-term survival benefit with chemo and radiation

MONDAY, March 9 (HealthDay News) -- Treatment with a combination of the chemotherapy drug temozolomide and radiotherapy increases survival for glioblastoma brain tumor patients better than radiotherapy alone, and the improvement persists for up to five years, say Swiss researchers.

Glioblastoma is the most common and aggressive form of primary brain tumor. For more than three decades, surgery followed by radiotherapy was the standard treatment for glioblastoma, but the average life expectancy was just nine to 12 months.

In 2004, a study reported that combined treatment with temozolomide and radiotherapy (TMZ/RT) reduced glioblastoma patients' risk of dying by 37 percent, compared with radiotherapy alone. Two years after treatment, 27 percent of those who had received TMZ/RT were alive, compared with 10 percent who had received radiotherapy alone.

But it wasn't known whether this survival benefit would persist over time.

In the new study, a team at the University of Lausanne Hospitals looked at the long-term outcomes of people in the large international trial. Three years after treatment, 16 percent of those in the TMZ/RT group were still alive, compared with 4 percent of the radiotherapy only group. Survival was 12.1 percent and 3 percent, respectively, after four years, and 9.8 percent and 1.9 percent after five years.

The improvements in survival among people who received TMZ/RT were seen across all subgroups, including people considered to have a poor prognosis, such as more elderly people and those whose tumor could not be surgically removed.

The study was published online and in the May print issue of The Lancet Oncology.

The researchers suggested that testing tumors for the methylation status of the MGMT gene would identify people most likely to benefit from TMZ/RT. Though this combination treatment can prolong survival, it is not a cure, they noted.

More information

The American Brain Tumor Association has more about glioblastoma and other brain tumors.



-- Robert Preidt



SOURCE: The Lancet Oncology, news release, March 8, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Radiation and drug combo helps boost efficacy of lung cancer treatment
2. Aerobic, Weight Training Combo Best Against Diabetes
3. New antibiotic drug combo to speed up treatment of tuberculosis
4. Drug Combo Helps Fight Marfan Syndrome
5. Drug Combo Blocks Pain Without Impairing Movement
6. Two-Drug Combo Fights Brain Tumors
7. CPR, Defibrillator Combo Boosts Cardiac Incident Survival
8. Drug Combo Boosts Multiple Myeloma Survival
9. Drug Combos Effective Against Rheumatoid Arthritis
10. Combo PET/CT Scan Helps Spot Breast Cancers Spread
11. Drug Combo With Antibiotic May Slow MS Progression
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Combo Treatment for Aggressive Brain Tumor May Lengthen Life
(Date:3/24/2017)... ... March 24, 2017 , ... ... related services to families and business owners across eastern Michigan, is connecting with ... families struggling with financial difficulties. , The Oxford/Orion FISH Food Pantry works to ...
(Date:3/24/2017)... ... 24, 2017 , ... In just two days, Aqua Design ... garden on Kickstarter . Surpassing the $100,000 milestone so quickly,10-times the original ... (and counting) already backing the campaign. , “We are very grateful for ...
(Date:3/24/2017)... ... 2017 , ... Northridge dentists, Dr. Michel Elyson ... apnea and TMJ at their office. TMJ, or temporomandibular joint disorder, has long ... is increasingly being treated at dental offices with newly developed procedures and appliances. ...
(Date:3/24/2017)... ... 24, 2017 , ... The law firm of Enea, Scanlan & Sirignano, ... Westchester resident Lauren C. Enea has joined the firm as an associate attorney. Ms. ... practice in elder law, Medicaid planning and applications, and Wills, Trusts and Estates. ...
(Date:3/24/2017)... Miami, FL (PRWEB) , ... March 24, 2017 ... ... HyGIeaCare Inc. ( http://www.hygieacare.com ) announced their partnership to prep patients for colonoscopy ... Health Endoscopy Centers in 87th Ave., Miami, FL. , The ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... 2017 New England Pediatric Device Consortium (NEPDC) ... including funding and in-kind service towards the commercialization of ... "Making blood draws less traumatic for children could ... experience better.  We,re looking forward to working with Velano ... care for the kids we treat," said Ann-Christine ...
(Date:3/24/2017)... 2017 Research and Markets has announced the addition ... Demand Forecast to 2022" report to their offering. ... The global wound care market was worth ... CAGR of 6.7% during 2016-2022 Among the various wound care ... in the global market in 2015. Among the various applications, surgical wound ...
(Date:3/24/2017)... Research and Markets has announced the addition of the "Dental ... ... markets for Dental Implants in US$ Million. The report provides separate comprehensive ... , Europe , Asia-Pacific , ... Annual estimates and forecasts are provided for the period 2015 through ...
Breaking Medicine Technology: