Navigation Links
Combo Treatment for Aggressive Brain Tumor May Lengthen Life
Date:3/9/2009

Study finds longer-term survival benefit with chemo and radiation

MONDAY, March 9 (HealthDay News) -- Treatment with a combination of the chemotherapy drug temozolomide and radiotherapy increases survival for glioblastoma brain tumor patients better than radiotherapy alone, and the improvement persists for up to five years, say Swiss researchers.

Glioblastoma is the most common and aggressive form of primary brain tumor. For more than three decades, surgery followed by radiotherapy was the standard treatment for glioblastoma, but the average life expectancy was just nine to 12 months.

In 2004, a study reported that combined treatment with temozolomide and radiotherapy (TMZ/RT) reduced glioblastoma patients' risk of dying by 37 percent, compared with radiotherapy alone. Two years after treatment, 27 percent of those who had received TMZ/RT were alive, compared with 10 percent who had received radiotherapy alone.

But it wasn't known whether this survival benefit would persist over time.

In the new study, a team at the University of Lausanne Hospitals looked at the long-term outcomes of people in the large international trial. Three years after treatment, 16 percent of those in the TMZ/RT group were still alive, compared with 4 percent of the radiotherapy only group. Survival was 12.1 percent and 3 percent, respectively, after four years, and 9.8 percent and 1.9 percent after five years.

The improvements in survival among people who received TMZ/RT were seen across all subgroups, including people considered to have a poor prognosis, such as more elderly people and those whose tumor could not be surgically removed.

The study was published online and in the May print issue of The Lancet Oncology.

The researchers suggested that testing tumors for the methylation status of the MGMT gene would identify people most likely to benefit from TMZ/RT. Though this combination treatment can prolong survival, it is not a cure, they noted.

More information

The American Brain Tumor Association has more about glioblastoma and other brain tumors.



-- Robert Preidt



SOURCE: The Lancet Oncology, news release, March 8, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Radiation and drug combo helps boost efficacy of lung cancer treatment
2. Aerobic, Weight Training Combo Best Against Diabetes
3. New antibiotic drug combo to speed up treatment of tuberculosis
4. Drug Combo Helps Fight Marfan Syndrome
5. Drug Combo Blocks Pain Without Impairing Movement
6. Two-Drug Combo Fights Brain Tumors
7. CPR, Defibrillator Combo Boosts Cardiac Incident Survival
8. Drug Combo Boosts Multiple Myeloma Survival
9. Drug Combos Effective Against Rheumatoid Arthritis
10. Combo PET/CT Scan Helps Spot Breast Cancers Spread
11. Drug Combo With Antibiotic May Slow MS Progression
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Combo Treatment for Aggressive Brain Tumor May Lengthen Life
(Date:7/21/2017)... (PRWEB) , ... July 21, 2017 , ... ... management assistance and financial planning services to families and business owners in northern ... event that promises to provide support to area adults with developmental challenges. , ...
(Date:7/21/2017)... ... July 21, 2017 , ... Adolfson & ... and improve the Ramsey County Medical Examiners Facility located in Saint Paul, Minn. ... million project is scheduled to start in late 2017/early 2018. , Staffed ...
(Date:7/21/2017)... ... July 21, 2017 , ... ... Theater of Witness , was awarded a $300,000 grant from The Pew ... fosters empathy, comfort with ambiguity and the recognition of one’s own limits among ...
(Date:7/21/2017)... , ... July 21, 2017 , ... Bernard R. Bach, ... President of the American Orthopaedic Society of Sports Medicine (AOSSM) , received the ... the AOSSM Annual Meeting in Toronto, Canada. This prestigious award is given annually to ...
(Date:7/21/2017)... , ... July 21, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House ... use of violence and aggression to solve problems and pleads with world leaders to be ... armed forces do not bring peace. He says there is a peaceful and positive way ...
Breaking Medicine News(10 mins):
(Date:7/21/2017)... SPRING, Md. and RESEARCH TRIANGLE ... United Therapeutics Corporation (NASDAQ: UTHR ) announced ... financial results before the market opens on Thursday, July ... Therapeutics will host a teleconference on Thursday, July 27, ... accessible by dialing 1-877-351-5881, with international callers dialing 1-970-315-0533.  ...
(Date:7/19/2017)... , July 19, 2017  Mako Medical Laboratories partnered ... the Military Family Assistance Fund (MFA) to bring 140 ... to visit with their families one last time before ... coordinate the travel and logistics needed for these soldiers. ... soldiers and their families. We just wish we could ...
(Date:7/14/2017)... , July 13, 2017 It should come ... States is in the midst of a crippling ... , since 1999, the number of overdose deaths from opiate-based ... in over half a million dead from 2001 to 2015". ... oxycodone, and hydrocodone has similarly quadrupled, drawing a compelling link ...
Breaking Medicine Technology: