Navigation Links
Combo Treatment for Aggressive Brain Tumor May Lengthen Life
Date:3/9/2009

Study finds longer-term survival benefit with chemo and radiation

MONDAY, March 9 (HealthDay News) -- Treatment with a combination of the chemotherapy drug temozolomide and radiotherapy increases survival for glioblastoma brain tumor patients better than radiotherapy alone, and the improvement persists for up to five years, say Swiss researchers.

Glioblastoma is the most common and aggressive form of primary brain tumor. For more than three decades, surgery followed by radiotherapy was the standard treatment for glioblastoma, but the average life expectancy was just nine to 12 months.

In 2004, a study reported that combined treatment with temozolomide and radiotherapy (TMZ/RT) reduced glioblastoma patients' risk of dying by 37 percent, compared with radiotherapy alone. Two years after treatment, 27 percent of those who had received TMZ/RT were alive, compared with 10 percent who had received radiotherapy alone.

But it wasn't known whether this survival benefit would persist over time.

In the new study, a team at the University of Lausanne Hospitals looked at the long-term outcomes of people in the large international trial. Three years after treatment, 16 percent of those in the TMZ/RT group were still alive, compared with 4 percent of the radiotherapy only group. Survival was 12.1 percent and 3 percent, respectively, after four years, and 9.8 percent and 1.9 percent after five years.

The improvements in survival among people who received TMZ/RT were seen across all subgroups, including people considered to have a poor prognosis, such as more elderly people and those whose tumor could not be surgically removed.

The study was published online and in the May print issue of The Lancet Oncology.

The researchers suggested that testing tumors for the methylation status of the MGMT gene would identify people most likely to benefit from TMZ/RT. Though this combination treatment can prolong survival, it is not a cure, they noted.

More information

The American Brain Tumor Association has more about glioblastoma and other brain tumors.



-- Robert Preidt



SOURCE: The Lancet Oncology, news release, March 8, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Radiation and drug combo helps boost efficacy of lung cancer treatment
2. Aerobic, Weight Training Combo Best Against Diabetes
3. New antibiotic drug combo to speed up treatment of tuberculosis
4. Drug Combo Helps Fight Marfan Syndrome
5. Drug Combo Blocks Pain Without Impairing Movement
6. Two-Drug Combo Fights Brain Tumors
7. CPR, Defibrillator Combo Boosts Cardiac Incident Survival
8. Drug Combo Boosts Multiple Myeloma Survival
9. Drug Combos Effective Against Rheumatoid Arthritis
10. Combo PET/CT Scan Helps Spot Breast Cancers Spread
11. Drug Combo With Antibiotic May Slow MS Progression
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Combo Treatment for Aggressive Brain Tumor May Lengthen Life
(Date:6/27/2016)... (PRWEB) , ... June 27, 2016 , ... "FCPX editors ... customizable inside of Final Cut Pro X," said Christina Austin - CEO of Pixel ... style. Final Cut Pro X users can now reveal the media of ...
(Date:6/27/2016)... ... June 27, 2016 , ... TopConsumerReviews.com recently awarded their highest five-star rating ... Millions of individuals in the United States and Canada wear eyeglasses. Once considered to ... correct vision and make a fashion statement. Even celebrities use glasses as a way ...
(Date:6/26/2016)... Carolina (PRWEB) , ... June 26, 2016 , ... ... of a new product that was developed to enhance the health of felines. The ... centuries. , The two main herbs in the PawPaws Cat Kidney Support ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery services, can ... Surgery and to Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey ... cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, ... and his M.D from the David Geffen School of Medicine at UCLA. He trained ... Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 23, 2016 Research and Markets has ... Market Analysis 2016 - Forecast to 2022" report to ... report contains up to date financial data derived from varied ... major trends with potential impact on the market during the ... segmentation which comprises of sub markets, regional and country level ...
(Date:6/23/2016)... Ill. and INDIANAPOLIS , ... students receiving a Lilly Diabetes Tomorrow,s Leaders Scholarship is ... 2016 scholarship winners, announced today online at www.diabetesscholars.org ... let type 1 diabetes stand in the way of ... has supported the Foundation,s scholarship program since 2012, and ...
(Date:6/23/2016)... Research and Markets has announced the addition ... States, China, Japan, Brazil, United Kingdom, Germany, France, Italy, ... Surgical Procedure Volumes: Global ... surgical procedure volume data in a geographic context. The ... of growth drivers and inhibitors, including world population growth, ...
Breaking Medicine Technology: