Navigation Links
Combo Treatment Ups Survival When Cancer Spreads to Abdominal Lining

Studies found it made difference when disease moved from colon, appendix

FRIDAY, March 14 (HealthDay News) -- In certain patients with cancer that has spread to the peritoneum -- the membrane lining the abdominal cavity -- surgery combined with a special kind of chemotherapy can improve survival rates, Wake Forest University researchers report.

The findings are from one of two Wake Forest studies presented at this week's annual meeting of the Society of Surgical Oncology in Chicago.

The first study was a phase I trial to establish the maximum tolerated dose of oxaliplatin used in Intraperitoneal Hyperthermic Chemotherapy (IPHC) in treating colorectal and appendix cancers that have spread to the peritoneum. The 15-patient study found that IPHC at a dose of 200 mg/m is well-tolerated and is the maximum tolerated dose for a two-hour chemoperfusion.

"Based on the data from this phase I study, we propose to conduct a larger trial with oxaliplatin dose to study its efficacy in improving outcomes in patients with peritoneal carcinoma," Dr. John H. Stewart IV, an assistant professor of surgery in the section of surgical oncology, said in a prepared statement.

In the second study, researchers examined the use of IPHC in patients with peritoneal or hepatic metastases (HM), or liver malignancy that has spread from colorectal cancer. The study included 144 patients (17 with liver cancer) who had surgery to remove as much of the cancer as possible, followed by IPHC.

Median overall survival for those without HM was 22.7 months, compared to 15.8 months for those with HM. This was not a significant difference, the researchers said.

The study also found that two- and four-year survival rates for the HM patients were 34 percent and 11.3 percent. The presence of malignant fluid in the abdominal cavity was a significant predictor of decreased survival among patients with HM.

More information

Cancer Research UK has more about peritoneal cancer.

-- Robert Preidt

SOURCE: Wake Forest University Baptist Medical Center, news release, March 14, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Radiation and drug combo helps boost efficacy of lung cancer treatment
2. Aerobic, Weight Training Combo Best Against Diabetes
3. New antibiotic drug combo to speed up treatment of tuberculosis
4. Drug Combo Helps Fight Marfan Syndrome
5. Drug Combo Blocks Pain Without Impairing Movement
6. Two-Drug Combo Fights Brain Tumors
7. CPR, Defibrillator Combo Boosts Cardiac Incident Survival
8. Drug Combo Boosts Multiple Myeloma Survival
9. Drug Combos Effective Against Rheumatoid Arthritis
10. Combo PET/CT Scan Helps Spot Breast Cancers Spread
11. Drug Combo With Antibiotic May Slow MS Progression
Post Your Comments:
Related Image:
Combo Treatment Ups Survival When Cancer Spreads to Abdominal Lining
(Date:6/27/2016)... ... June 27, 2016 , ... "FCPX editors can now ... of Final Cut Pro X," said Christina Austin - CEO of Pixel Film Studios. ... Final Cut Pro X users can now reveal the media of their split ...
(Date:6/27/2016)... ... 27, 2016 , ... A revolution is underway. Brooklyn-based ... experience for the millions of people who require these medical transport services annually. ... through the use of technology. Now, SmartEMS has put forth an industry-changing app ...
(Date:6/26/2016)... , ... June 26, 2016 , ... On June 10-11, ... of the 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, ... the city’s history as home to some of the world’s leading providers of cereal ...
(Date:6/26/2016)... ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer ... through a fitness app. The fitness app plans to fix the two major problems leading ... a one size fits all type program , They don’t eliminate all the ...
(Date:6/25/2016)... ... , ... Austin residents seeking Mohs surgery services, can now turn to Dr. ... Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization to include ... in Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction of Glenn ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Mass. , June 24, 2016   Pulmatrix, ... pharmaceutical company developing innovative inhaled drugs, announced today that ... Russell Investments reconstituted its comprehensive set of ... "This is an important milestone for Pulmatrix," ... will increase shareholder awareness of our progress in developing ...
(Date:6/23/2016)... Calif. , June 23, 2016 Any dentist ... many challenges of the current process. Many of them do ... of the technical difficulties and high laboratory costs involved. And ... to offer it at such a high cost that the ... it. Dr. Parsa Zadeh , founder of ...
(Date:6/23/2016)... ANGELES , June 23, 2016 ... CAPR ), a biotechnology company focused ... therapeutics, today announced that patient enrollment in its ... in Duchenne) has exceeded 50% of its 24-patient ... enrollment in the third quarter of 2016, and ...
Breaking Medicine Technology: