Navigation Links
Combo Treatment Ups Survival When Cancer Spreads to Abdominal Lining
Date:3/14/2008

Studies found it made difference when disease moved from colon, appendix

FRIDAY, March 14 (HealthDay News) -- In certain patients with cancer that has spread to the peritoneum -- the membrane lining the abdominal cavity -- surgery combined with a special kind of chemotherapy can improve survival rates, Wake Forest University researchers report.

The findings are from one of two Wake Forest studies presented at this week's annual meeting of the Society of Surgical Oncology in Chicago.

The first study was a phase I trial to establish the maximum tolerated dose of oxaliplatin used in Intraperitoneal Hyperthermic Chemotherapy (IPHC) in treating colorectal and appendix cancers that have spread to the peritoneum. The 15-patient study found that IPHC at a dose of 200 mg/m is well-tolerated and is the maximum tolerated dose for a two-hour chemoperfusion.

"Based on the data from this phase I study, we propose to conduct a larger trial with oxaliplatin dose to study its efficacy in improving outcomes in patients with peritoneal carcinoma," Dr. John H. Stewart IV, an assistant professor of surgery in the section of surgical oncology, said in a prepared statement.

In the second study, researchers examined the use of IPHC in patients with peritoneal or hepatic metastases (HM), or liver malignancy that has spread from colorectal cancer. The study included 144 patients (17 with liver cancer) who had surgery to remove as much of the cancer as possible, followed by IPHC.

Median overall survival for those without HM was 22.7 months, compared to 15.8 months for those with HM. This was not a significant difference, the researchers said.

The study also found that two- and four-year survival rates for the HM patients were 34 percent and 11.3 percent. The presence of malignant fluid in the abdominal cavity was a significant predictor of decreased survival among patients with HM.

More information

Cancer Research UK has more about peritoneal cancer.



-- Robert Preidt



SOURCE: Wake Forest University Baptist Medical Center, news release, March 14, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Radiation and drug combo helps boost efficacy of lung cancer treatment
2. Aerobic, Weight Training Combo Best Against Diabetes
3. New antibiotic drug combo to speed up treatment of tuberculosis
4. Drug Combo Helps Fight Marfan Syndrome
5. Drug Combo Blocks Pain Without Impairing Movement
6. Two-Drug Combo Fights Brain Tumors
7. CPR, Defibrillator Combo Boosts Cardiac Incident Survival
8. Drug Combo Boosts Multiple Myeloma Survival
9. Drug Combos Effective Against Rheumatoid Arthritis
10. Combo PET/CT Scan Helps Spot Breast Cancers Spread
11. Drug Combo With Antibiotic May Slow MS Progression
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Combo Treatment Ups Survival When Cancer Spreads to Abdominal Lining
(Date:6/26/2016)... Orion, Clarkston, Michigan (PRWEB) , ... June 26, ... ... with respect to fertility once they have been diagnosed with endometriosis. These women ... intercourse but they also require a comprehensive approach that can help for preservation ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs ... College of Mohs Surgery and to Dr. Russell Peckham for medical and surgical dermatology. ... treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture ... said Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package ... Final Cut Pro X . Simply select a ProHand generator and drag it ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, ... and his M.D from the David Geffen School of Medicine at UCLA. He trained ... Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where ...
(Date:6/25/2016)... ... 2016 , ... On Friday, June 10, Van Mitchell, Secretary of the Maryland ... iHire in recognition of their exemplary accomplishments in worksite health promotion. , The Wellness ... & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one of ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016  In a startling report released today, ... residents by lacking a comprehensive, proven plan to eliminate prescription opioid ... ranking of how states are tackling the worst drug crisis in ... states – Kentucky , New Mexico ... . Of the 28 failing states, three – ...
(Date:6/23/2016)... , June 23, 2016 Research ... MEMS Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data ... analysis. Assessment of major trends with potential impact on the ... analysis of market segmentation which comprises of sub markets, regional ...
(Date:6/23/2016)... Research and Markets has announced the addition of ... their offering. The current ... environment for MedImmune to enter. The US ageing population creates ... drive considerable growth for effective anti-influenza medications. The introduction of ... but development is still in its infancy. ...
Breaking Medicine Technology: