Navigation Links
Combo Treatment Best for Elderly Lymphoma Patients
Date:1/15/2008

Adding monoclonal antibody to chemo lowered toxicity, lengthened survival

TUESDAY, Jan. 15 (HealthDay News) -- Treatment that combines the monoclonal antibody rituximab with six cycles of chemotherapy improves survival in elderly patients with aggressive lymphoma, German doctors report.

Their research was published in the Jan. 15 online issue of The Lancet Oncology. The study was expected to appear in the February print issue of the journal.

Researchers studied 1,222 patients aged 60 to 80 with diffuse B-cell lymphoma and found that six cycles of CHOP-14 chemotherapy (cyclophosphamide, doxorubicin, vincristine, and prednisolone) combined with eight applications of rituximab (R-CHOP-14) was as effective as eight cycles of CHOP-14 chemotherapy alone.

Dr. Michael Pfreundschuh, of the Saarland University Medical School in Homburg, and his colleagues noted this means elderly patients can be spared the toxicity and side effects of two additional cycles of chemotherapy.

The study found that three-year, event-free survival was: 47.2 percent after six cycles of CHOP-14; 53 percent after eight cycles of CHOP-14; 66.5 percent after six cycles of R-CHOP-14; and 63.1 percent after eight cycles of R-CHOP-14.

Three-year overall survival was: 67.7 percent for six cycles of CHOP-14; 66 percent for eight cycles of CHOP-14; 78.1 percent for six cycles of R-CHOP-14; and 72.5 percent for eight cycles of R-CHOP-14.

"Six cycles of R-CHOP-14 significantly improved event-free, progression-free, and overall survival over six cycles of CHOP-14 treatment. Response-adapted addition of chemotherapy beyond six cycles, though widely practiced, is not justified," the researchers wrote. "Of the four regimens assessed in this study, six cycles of R-CHOP-14 is the preferred treatment for elderly patients, with which other approaches should be compared."

This diffuse lymphoma is an aggressive type of non-Hodgkin's lymphoma. More than half of patients with this type of lymphoma are more than 60 years old.

More information

The American Cancer Society has more about non-Hodgkin's lymphoma.



-- Robert Preidt



SOURCE: The Lancet, news release, Jan. 14, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Combo Therapy Cuts Prostate Cancer Death Rates
2. Drug Combo Halves Death Risk for Severe COPD Patients
3. Aspirin, Hormone Therapy Combo Can Shorten Lives of Prostate Cancer Patients
4. New Combo Treatment Extends Kidney Cancer Survival
5. Drug Combo With Antibiotic May Slow MS Progression
6. Combo PET/CT Scan Helps Spot Breast Cancers Spread
7. Drug Combos Effective Against Rheumatoid Arthritis
8. Drug Combo Boosts Multiple Myeloma Survival
9. CPR, Defibrillator Combo Boosts Cardiac Incident Survival
10. Two-Drug Combo Fights Brain Tumors
11. Drug Combo Blocks Pain Without Impairing Movement
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... ... PawPaws brand pet supplements owned by Whole Health Supply is ... of felines. The formula is all-natural and is made from Chinese herbs that have ... Kidney Support Supplement Soft Chews are Astragalus Root Extract and Rehmannia Root Extract ...
(Date:6/25/2016)... ... ... Austin residents seeking Mohs surgery services, can now turn to Dr. Jessica ... Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization to include Mohs ... Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction of Glenn Goldstein, ...
(Date:6/25/2016)... ... ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his Bachelors in ... School of Medicine at UCLA. He trained in Internal Medicine at Scripps Green Hospital ... at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to train in ...
(Date:6/24/2016)... Los Angeles, CA (PRWEB) , ... June 24, 2016 , ... ... plastic surgery procedures that most people are unfamiliar with. The article goes on to ... known procedures, but also many of these less common operations such as calf and ...
(Date:6/24/2016)... ... June 24, 2016 , ... The ... in Dallas that it will receive two significant new grants to support its ... PHA marked its 25th anniversary by recognizing patients, medical professionals and scientists for ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 ... CAPR ), a biotechnology company focused on ... today announced that patient enrollment in its ongoing ... Duchenne) has exceeded 50% of its 24-patient target. ... in the third quarter of 2016, and to ...
(Date:6/23/2016)... June 23, 2016 , , ... July 7, 2016 , , , , LOCATION: , , ... , , , EXPERT PANELISTS:  , , , Frost & ... Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar and Unmesh Lal, ... The global pharmaceutical industry is witnessing an exceptional era. Several new ...
(Date:6/23/2016)... June 23, 2016 Revolutionary technology ... Oticon , industry leaders in advanced audiology and ... Oticon Opn ™, the world,s first internet connected ... for IoT devices.      (Photo: http://photos.prnewswire.com/prnh/20160622/382240 ... a number of ,world firsts,: , TwinLink™ ...
Breaking Medicine Technology: