Navigation Links
Combo Treatment Best for Elderly Lymphoma Patients

Adding monoclonal antibody to chemo lowered toxicity, lengthened survival

TUESDAY, Jan. 15 (HealthDay News) -- Treatment that combines the monoclonal antibody rituximab with six cycles of chemotherapy improves survival in elderly patients with aggressive lymphoma, German doctors report.

Their research was published in the Jan. 15 online issue of The Lancet Oncology. The study was expected to appear in the February print issue of the journal.

Researchers studied 1,222 patients aged 60 to 80 with diffuse B-cell lymphoma and found that six cycles of CHOP-14 chemotherapy (cyclophosphamide, doxorubicin, vincristine, and prednisolone) combined with eight applications of rituximab (R-CHOP-14) was as effective as eight cycles of CHOP-14 chemotherapy alone.

Dr. Michael Pfreundschuh, of the Saarland University Medical School in Homburg, and his colleagues noted this means elderly patients can be spared the toxicity and side effects of two additional cycles of chemotherapy.

The study found that three-year, event-free survival was: 47.2 percent after six cycles of CHOP-14; 53 percent after eight cycles of CHOP-14; 66.5 percent after six cycles of R-CHOP-14; and 63.1 percent after eight cycles of R-CHOP-14.

Three-year overall survival was: 67.7 percent for six cycles of CHOP-14; 66 percent for eight cycles of CHOP-14; 78.1 percent for six cycles of R-CHOP-14; and 72.5 percent for eight cycles of R-CHOP-14.

"Six cycles of R-CHOP-14 significantly improved event-free, progression-free, and overall survival over six cycles of CHOP-14 treatment. Response-adapted addition of chemotherapy beyond six cycles, though widely practiced, is not justified," the researchers wrote. "Of the four regimens assessed in this study, six cycles of R-CHOP-14 is the preferred treatment for elderly patients, with which other approaches should be compared."

This diffuse lymphoma is an aggressive type of non-Hodgkin's lymphoma. More than half of patients with this type of lymphoma are more than 60 years old.

More information

The American Cancer Society has more about non-Hodgkin's lymphoma.

-- Robert Preidt

SOURCE: The Lancet, news release, Jan. 14, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Combo Therapy Cuts Prostate Cancer Death Rates
2. Drug Combo Halves Death Risk for Severe COPD Patients
3. Aspirin, Hormone Therapy Combo Can Shorten Lives of Prostate Cancer Patients
4. New Combo Treatment Extends Kidney Cancer Survival
5. Drug Combo With Antibiotic May Slow MS Progression
6. Combo PET/CT Scan Helps Spot Breast Cancers Spread
7. Drug Combos Effective Against Rheumatoid Arthritis
8. Drug Combo Boosts Multiple Myeloma Survival
9. CPR, Defibrillator Combo Boosts Cardiac Incident Survival
10. Two-Drug Combo Fights Brain Tumors
11. Drug Combo Blocks Pain Without Impairing Movement
Post Your Comments:
(Date:6/25/2016)... ... June 25, 2016 , ... ... non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as a method ... —Johnson is one of the first doctors to perform the treatment. Orthobiologics are ...
(Date:6/25/2016)... ... , ... Conventional wisdom preaches the benefits of moderation, whether it’s a matter ... bar too high can result in disappointment, perhaps even self-loathing. However, those who set ... , Research from reveals that behind the tendency to set low ...
(Date:6/24/2016)... ... 2016 , ... Those who have experienced traumatic events may suffer from a ... such as drug or alcohol abuse, as a coping mechanism. To avoid this pain ... following a traumatic event. , Trauma sufferers tend to feel a range of emotions, ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was ... his family verbally and physically. , “When something upset him, he couldn’t control his emotions,” ... He would throw rocks at my other children and say he was going to kill ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, ... Elite. The attorneys chosen by their peers for this recognition are considered among the ... Traurig Shareholders received special honors as members of this year’s Legal Elite Hall of ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 According ... by Type (Standard Pen Needles, Safety Pen Needles), Needle ... GLP-1, Growth Hormone), Mode of Purchase (Retail, Non-Retail) - ... This report studies the market for the forecast period ... reach USD 2.81 Billion by 2021 from USD 1.65 ...
(Date:6/23/2016)... , June 23, 2016  MedSource announced today ... its e-clinical software solution of choice.  This latest ... possible value to their clients by offering a ... preferred relationship establishes nowEDC as the EDC platform ... MedSource,s full-service clients.  "nowEDC has long been a ...
(Date:6/23/2016)... , June 23, 2016  In a startling report released today, ... their residents by lacking a comprehensive, proven plan to eliminate prescription ... definitive ranking of how states are tackling the worst drug crisis ... four states – Kentucky , New ... Vermont . Of the 28 failing states, three – ...
Breaking Medicine Technology: