Navigation Links
Combo Treatment Best for Elderly Lymphoma Patients
Date:1/15/2008

Adding monoclonal antibody to chemo lowered toxicity, lengthened survival

TUESDAY, Jan. 15 (HealthDay News) -- Treatment that combines the monoclonal antibody rituximab with six cycles of chemotherapy improves survival in elderly patients with aggressive lymphoma, German doctors report.

Their research was published in the Jan. 15 online issue of The Lancet Oncology. The study was expected to appear in the February print issue of the journal.

Researchers studied 1,222 patients aged 60 to 80 with diffuse B-cell lymphoma and found that six cycles of CHOP-14 chemotherapy (cyclophosphamide, doxorubicin, vincristine, and prednisolone) combined with eight applications of rituximab (R-CHOP-14) was as effective as eight cycles of CHOP-14 chemotherapy alone.

Dr. Michael Pfreundschuh, of the Saarland University Medical School in Homburg, and his colleagues noted this means elderly patients can be spared the toxicity and side effects of two additional cycles of chemotherapy.

The study found that three-year, event-free survival was: 47.2 percent after six cycles of CHOP-14; 53 percent after eight cycles of CHOP-14; 66.5 percent after six cycles of R-CHOP-14; and 63.1 percent after eight cycles of R-CHOP-14.

Three-year overall survival was: 67.7 percent for six cycles of CHOP-14; 66 percent for eight cycles of CHOP-14; 78.1 percent for six cycles of R-CHOP-14; and 72.5 percent for eight cycles of R-CHOP-14.

"Six cycles of R-CHOP-14 significantly improved event-free, progression-free, and overall survival over six cycles of CHOP-14 treatment. Response-adapted addition of chemotherapy beyond six cycles, though widely practiced, is not justified," the researchers wrote. "Of the four regimens assessed in this study, six cycles of R-CHOP-14 is the preferred treatment for elderly patients, with which other approaches should be compared."

This diffuse lymphoma is an aggressive type of non-Hodgkin's lymphoma. More than half of patients with this type of lymphoma are more than 60 years old.

More information

The American Cancer Society has more about non-Hodgkin's lymphoma.



-- Robert Preidt



SOURCE: The Lancet, news release, Jan. 14, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Combo Therapy Cuts Prostate Cancer Death Rates
2. Drug Combo Halves Death Risk for Severe COPD Patients
3. Aspirin, Hormone Therapy Combo Can Shorten Lives of Prostate Cancer Patients
4. New Combo Treatment Extends Kidney Cancer Survival
5. Drug Combo With Antibiotic May Slow MS Progression
6. Combo PET/CT Scan Helps Spot Breast Cancers Spread
7. Drug Combos Effective Against Rheumatoid Arthritis
8. Drug Combo Boosts Multiple Myeloma Survival
9. CPR, Defibrillator Combo Boosts Cardiac Incident Survival
10. Two-Drug Combo Fights Brain Tumors
11. Drug Combo Blocks Pain Without Impairing Movement
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... While it’s ... poses a problem. Fortunately, an inventor from Austin, Texas, has identified a solution. , ... medication in darkness or restricted lighting. As such, it eliminates the need to turn ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... process to promote standards of excellence for the field of eating disorders, announces ... 22 – 25, 2018 in Orlando, Florida at the Omni Resort at ChampionsGate. ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... PharmD ‘17, and Jennifer Huggins, PharmD ’17, along with clinical associate professor ... prevention of cardiovascular diseases during the 15th Annual Women’s Health Conference. The ...
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton Lakes , ... mock evacuation of the facility as part of a disaster drill on October 3rd. ... EMS and Shelton City Emergency Manager, as well as the Connecticut Long Term ...
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association (VNA) of Somerset Hills ... specialty vendors and unique items from across the nation, this holiday-themed event will raise ... offered by the VNA. The boutique will be open Saturday, November 4 (10:00 ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... PHILADELPHIA , Oct. 2, 2017 Halo Labs announces ... particle analysis system called the HORIZON at MIBio 2017 in ... analyzes subvisible and visible particulate matter in biopharmaceutical samples with unprecedented ... use of the novel technique Backgrounded Membrane Imaging. ... The HORIZON subvisible particle analysis system ...
(Date:9/28/2017)... 2017 Hill-Rom Holdings, Inc. (NYSE: HRC), will ... and webcast on Friday, November 3, 2017, beginning at ... at approximately 8:30 a.m. (CDT) / 9:30 a.m. (EDT). ... financial performance and guidance for 2018, Hill-Rom executives will ... operational performance, and long-range financial outlook through 2020. ...
(Date:9/27/2017)... their devotion to personalized service, SMP Pharmacy Solutions announces their ... South Florida Business Journal,s 50 Fastest-Growing Companies, and listed for ... specialty pharmacy has found its niche.  To that end, the ... by SFBJ as the 2017 Power Leader in Health Care. ... award in October, Bardisa said of the three achievements, "It,s ...
Breaking Medicine Technology: