Navigation Links
Combo Therapy Shows Promise in Treating Brain Tumors
Date:1/18/2008

Radiation seeds, chemo wafers slowed disease, boosted survival

FRIDAY, Jan. 18 (HealthDay News) -- Implantation of radioactive seeds and chemotherapy wafers following surgery shows promise in treating malignant brain tumors, a new study finds.

The early-phase clinical trial, led by researchers at The Neuroscience Institute at the University of Cincinnati and University Hospital, included 34 patients who had the combination therapy after surgery to remove recurrent glioblastoma multiforme (GBM).

The study, designed to assess the safety and effectiveness of simultaneous use of radioactive seeds and chemotherapy wafers, found that median patient survival was 69 weeks. Almost 25 percent (eight) of the patients survived two years. Patients with recurrent GBM who receive conventional treatment (chemotherapy) have a median survival of about 26 weeks.

About 25 percent of patients developed brain tissue death, which was treated with surgery or hyperbaric oxygen and did not affect survival. That rate of brain tissue death appeared to be higher than what's seen in patients treated with either seeds or wafers alone.

"Treatment of recurrent GBM presents a major challenge to neurosurgeons and neuro-oncologists," study author Dr. Ronald Warnick, a professor of neurosurgery, said in a prepared statement.

"Glioblastoma is an aggressive, highly malignant tumor with unclear boundaries. Because of its diffuse nature, surgeons are unable to remove it completely, and it regrows in the majority of patients. Our aim is to find a way to keep the infiltrating glioblastoma cells from growing into adjacent, health tissue," he said.

The radiation seeds, each about the size of a grain of rice, deliver radiation to the targeted area for six months. The chemotherapy wafers, which are about the size of a nickel, are placed along the surface of the brain.

Compared with the use of either one alone, the combination of the seeds and wafers appeared to further delay disease progression and increase length of patient survival, Warnick said.

However, he noted that the effectiveness of the combination therapy is not definitive, because this study did not include a control group.

The study was published in the February issue of the Journal of Neurosurgery.

More information

The U.S. National Cancer Institute has more about brain tumors.



-- Robert Preidt



SOURCE: University of Cincinnati, news release, Jan. 18, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Combo Treatment Best for Elderly Lymphoma Patients
2. Combo Therapy Cuts Prostate Cancer Death Rates
3. Drug Combo Halves Death Risk for Severe COPD Patients
4. Aspirin, Hormone Therapy Combo Can Shorten Lives of Prostate Cancer Patients
5. New Combo Treatment Extends Kidney Cancer Survival
6. Drug Combo With Antibiotic May Slow MS Progression
7. Combo PET/CT Scan Helps Spot Breast Cancers Spread
8. Drug Combos Effective Against Rheumatoid Arthritis
9. Drug Combo Boosts Multiple Myeloma Survival
10. CPR, Defibrillator Combo Boosts Cardiac Incident Survival
11. Two-Drug Combo Fights Brain Tumors
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Combo Therapy Shows Promise in Treating Brain Tumors
(Date:12/8/2016)... ... 2016 , ... California Senate Bill (SB) 863, signed into law in 2012, ... and 2014, according to CompScope™ Medical Benchmarks for California, 17th Edition , a ... study, medical payments per claim in California decreased 4 percent in 2013 and then ...
(Date:12/8/2016)... San Francisco, California (PRWEB) , ... December 08, 2016 , ... ... health coaches, has raised an $18M Series B led by Canvas Ventures . ... use the capital to scale its mobile platform to serve more consumers who are ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... services from offices headquartered in Jefferson County, is announcing the launch of a ... Birmingham. , The number of homeless women and children in Birmingham has grown ...
(Date:12/8/2016)... ... December 08, 2016 , ... The Compretta Insurance Agency, a family ... in and around the Hancock County area, is announcing the launch of a charity ... , The Hancock County Food Pantry has worked for more than 30 years to ...
(Date:12/7/2016)... ... December 07, 2016 , ... DrugDev again demonstrated its dedication to ... of the early adopters completing EU-U.S. Privacy Shield Certification from the U.S. Department of ... both sides of the Atlantic with a mechanism to comply with EU data protection ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... , Dec. 8, 2016  Pennsylvania Physician General ... Drug and Alcohol Programs Gary Tennis ... medications, known as benzodiazepines, developed with the help ... are medications that are frequently prescribed for anxiety ... are used with opioid pain medications, benzodiazepines pose ...
(Date:12/8/2016)... Dec. 8, 2016 True Health Diagnostics ... leading-edge laboratory services and management expertise to hospital ... , allowing more doctors and patients to benefit ... solutions. Logo - http://photos.prnewswire.com/prnh/20161208/447162LOGO ... systems, under pressure to contain costs, have struggled ...
(Date:12/8/2016)... NORWALK, Connecticut , 8. Dezember 2016 Mederi Therapeutics Inc ... Stretta-Therapie – eine nicht-operative Behandlungsmethode für gastroösophageale Refluxerkrankung (GERD) – in ... Reading ... Live ... by Professor Jun Liu, Director of Endoscopy at Wuhan Union Hospital ...
Breaking Medicine Technology: