Navigation Links
Combo Therapy Knocks Out Melanoma Tumors
Date:6/1/2008

Chemo was more effective after a protein in growths was inhibited, researchers say

SUNDAY, June 1 (HealthDay News) -- Chemotherapy may be more effective on melanoma tumors if a protein frequently found in the growth can first be disabled, a new study reports.

Researchers at the Duke Comprehensive Cancer Center found the drug ADH-1, which makes it difficult for cells to properly bind to one another, helped chemotherapy completely destroy the tumors in twice as many patients than with chemo alone. Sixteen people with regionally advanced melanoma, in which the cancerous growths appear and spread mainly on the limbs, participated in the pilot study.

"Eight of the patients in the study had complete responses to therapy, meaning their tumors completely disappeared," study lead investigator Dr. Georgia Beasley, a medical student at Duke, said in a prepared statement. "This is very encouraging, and we look forward to continuing this study and then eventually moving on to a phase III trial."

Without ADH-1, patients generally have complete responses about 25 percent to 35 percent of the time.

"When chemotherapy was applied to the tumor in this weakened state, it was much more effective compared to conventional therapy alone," study senior investigator Dr. Douglas Tyler, a surgeon at Duke and the Durham Veterans Affairs Medical Center, said in a prepared statement.

The researchers were expected to present their findings Sunday at the American Society of Clinical Oncology annual meeting, in Chicago.

"These early results really speak to the importance of developing combination therapies," Beasley said. "Earlier animal results showed that using ADH-1 alone was not an effective treatment, but in combination with chemotherapy, the results, both pre-clinically and clinically, have been very exciting."

Malignant melanoma is increasing at a rate faster than any other cancer -- 60,000 new cases are expected to be diagnosed this year in the United States alone. When the growths spread beyond the primary site, the disease is rarely curable, and treatment is limited.

More information

The American Academy of Family Physicians has more about melanoma.



-- Kevin McKeever



SOURCE: Duke University Medical Center, news release, June 1, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Combo Kidney-Pancreas Transplant Boosts Survival in Diabetics
2. Breast cancer risk amplified by additional genes in combo with BRCA mutation
3. Celebrex-Lipitor combo may halt prostate cancer
4. Green Tea, Mushroom Extract Combo Slows Sarcomas
5. Hormone Combo May Provide Reversible Male Birth Control Tool
6. LG Electronics Debuts Unique Allergen-Reducing Steam Washer/Dryer Combo
7. Combo Treatment Ups Survival When Cancer Spreads to Abdominal Lining
8. MRI/PET scanner combo
9. Treatment Combo for Pancreatic Cancer Has Limited Benefit
10. Raised Breast Cancer Risk Persists After Combo HRT Stopped
11. Combo Treatment Best for Melanoma, Advanced Ovarian Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the Christian history of ... Brink” is the creation of published author, William Nowers. Captain Nowers and his ... veteran, he spent thirty years in the Navy. Following his career as a ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest ... its plans to open a flagship location in Covington, LA at 401 N. U.S. ... Go store next to Office Depot in the Holiday Square shopping center. Its location ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical Informatics (ACMI) ... FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s ... Morris F. Collen, a pioneer in the field of medical informatics, this prestigious award ...
(Date:10/12/2017)... LOS ANGELES (PRWEB) , ... October 12, 2017 ... ... of Parsa Mohebi Hair Restoration, has recently contributed a medical article to the ... doctors, on cosmetictown.com. Dr. Mohebi’s article spotlights the hair transplant procedure known as ...
(Date:10/12/2017)... ... ... On Saturday, October 21, the Health & Wellness Center at Florida Hospital ... for the American Heart Association Heart Walk. Teams of up to 10 people can ... their treadmills moving for 5 hours. Treadmills will start at 7:00 p.m. on Saturday, ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... Oct. 11, 2017  BioPharmX Corporation (NYSE MKT: BPMX) ... developed an innovative way to use nonlinear optical imaging ... of new drugs. ... Conference will show how researchers from BioPharmX and the ... School used a suite of imaging techniques in what ...
(Date:10/10/2017)... 2017  NDS received FDA 510(k) clearance in May 2017 for ... stand specifically designed for endoscopy environments. An innovative secondary monitor solution, ... solution to support the improvement of patient outcomes, procedural efficiency, and ... ... ...
(Date:10/4/2017)... , Oct. 4, 2017  South Korean-based healthcare ... CPR training aide "cprCUBE" on Kickstarter. The device will ... during cardiac arrests with better efficiency compared to the ... offers real-time feedback on efficacy of the compression for ... campaign has a goal to raise $5,000. ...
Breaking Medicine Technology: