Navigation Links
Combo Therapy Knocks Out Melanoma Tumors
Date:6/1/2008

Chemo was more effective after a protein in growths was inhibited, researchers say

SUNDAY, June 1 (HealthDay News) -- Chemotherapy may be more effective on melanoma tumors if a protein frequently found in the growth can first be disabled, a new study reports.

Researchers at the Duke Comprehensive Cancer Center found the drug ADH-1, which makes it difficult for cells to properly bind to one another, helped chemotherapy completely destroy the tumors in twice as many patients than with chemo alone. Sixteen people with regionally advanced melanoma, in which the cancerous growths appear and spread mainly on the limbs, participated in the pilot study.

"Eight of the patients in the study had complete responses to therapy, meaning their tumors completely disappeared," study lead investigator Dr. Georgia Beasley, a medical student at Duke, said in a prepared statement. "This is very encouraging, and we look forward to continuing this study and then eventually moving on to a phase III trial."

Without ADH-1, patients generally have complete responses about 25 percent to 35 percent of the time.

"When chemotherapy was applied to the tumor in this weakened state, it was much more effective compared to conventional therapy alone," study senior investigator Dr. Douglas Tyler, a surgeon at Duke and the Durham Veterans Affairs Medical Center, said in a prepared statement.

The researchers were expected to present their findings Sunday at the American Society of Clinical Oncology annual meeting, in Chicago.

"These early results really speak to the importance of developing combination therapies," Beasley said. "Earlier animal results showed that using ADH-1 alone was not an effective treatment, but in combination with chemotherapy, the results, both pre-clinically and clinically, have been very exciting."

Malignant melanoma is increasing at a rate faster than any other cancer -- 60,000 new cases are expected to be diagnosed this year in the United States alone. When the growths spread beyond the primary site, the disease is rarely curable, and treatment is limited.

More information

The American Academy of Family Physicians has more about melanoma.



-- Kevin McKeever



SOURCE: Duke University Medical Center, news release, June 1, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Combo Kidney-Pancreas Transplant Boosts Survival in Diabetics
2. Breast cancer risk amplified by additional genes in combo with BRCA mutation
3. Celebrex-Lipitor combo may halt prostate cancer
4. Green Tea, Mushroom Extract Combo Slows Sarcomas
5. Hormone Combo May Provide Reversible Male Birth Control Tool
6. LG Electronics Debuts Unique Allergen-Reducing Steam Washer/Dryer Combo
7. Combo Treatment Ups Survival When Cancer Spreads to Abdominal Lining
8. MRI/PET scanner combo
9. Treatment Combo for Pancreatic Cancer Has Limited Benefit
10. Raised Breast Cancer Risk Persists After Combo HRT Stopped
11. Combo Treatment Best for Melanoma, Advanced Ovarian Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/31/2016)... ... ... day, adults often find themselves reaching for a cup of coffee, an energy drink, or ... instead is a cup of Matcha green tea. Matcha is a premium green tea powder ... from early June to mid-July, when the leaves are the most tender. , ...
(Date:5/31/2016)... ... 31, 2016 , ... Twenty years ago it was revolutionary: enabling the people ... the voices they hear. But this approach has proven transformative, both for people who ... gained credibility and now is used around the world, but it still lags in ...
(Date:5/31/2016)... ... 31, 2016 , ... Spartan Bioscience today introduced the Spartan ... convenience. , The Cube is exceptionally small—it takes up the space of a ... into any space, whether in a hospital, doctor’s office, or pharmacy. , The ...
(Date:5/31/2016)... CA (PRWEB) , ... May 31, 2016 , ... WaterField ... for digital-minded professionals, announces the waxed-canvas and leather Duo Dopp Kit , the ... waxed canvas or ballistic nylon, the Duo is smartly designed for Dad’s ...
(Date:5/31/2016)... ... May 31, 2016 , ... Phynd Technologies, Inc. announced recently the signing of ... TX and Shore Medical Center – Somers Point, NJ. The new clients range in ... demonstrating the breadth of Phynd’s solution and its interoperability. , Houston Methodist is a ...
Breaking Medicine News(10 mins):
(Date:5/31/2016)... -- The global biomaterials market is driven by ... deaths from chronic diseases. According to research report, "Global Biomaterials ... and Forecasts (2016-2021) - (By Value; By Material Type - ... Care); By Region-North America, Europe , APAC, ... , Italy , Japan ...
(Date:5/31/2016)... , May 31, 2016 ... Health Assembly zur Eliminierung von viraler Hepatitis    ... eine historische Verpflichtung eingegangen, virale Hepatitis bis 2030 ... World Health Assembly haben sich die Staaten ... viraler Hepatitis (Global Viral Hepatitis Strategy) zu verabschieden, ...
(Date:5/30/2016)... India , May 30, 2016 /PRNewswire/ ... market research report "Healthcare Biometrics Market by ... (Signature, Voice)), Multifactor, Multimodal), Application (Workforce Management), ... Forecast to 2021", published by MarketsandMarkets, the ... Million by 2021 from USD 1,182.6 Million ...
Breaking Medicine Technology: