Navigation Links
Combo Therapy Knocks Out Melanoma Tumors
Date:6/1/2008

Chemo was more effective after a protein in growths was inhibited, researchers say

SUNDAY, June 1 (HealthDay News) -- Chemotherapy may be more effective on melanoma tumors if a protein frequently found in the growth can first be disabled, a new study reports.

Researchers at the Duke Comprehensive Cancer Center found the drug ADH-1, which makes it difficult for cells to properly bind to one another, helped chemotherapy completely destroy the tumors in twice as many patients than with chemo alone. Sixteen people with regionally advanced melanoma, in which the cancerous growths appear and spread mainly on the limbs, participated in the pilot study.

"Eight of the patients in the study had complete responses to therapy, meaning their tumors completely disappeared," study lead investigator Dr. Georgia Beasley, a medical student at Duke, said in a prepared statement. "This is very encouraging, and we look forward to continuing this study and then eventually moving on to a phase III trial."

Without ADH-1, patients generally have complete responses about 25 percent to 35 percent of the time.

"When chemotherapy was applied to the tumor in this weakened state, it was much more effective compared to conventional therapy alone," study senior investigator Dr. Douglas Tyler, a surgeon at Duke and the Durham Veterans Affairs Medical Center, said in a prepared statement.

The researchers were expected to present their findings Sunday at the American Society of Clinical Oncology annual meeting, in Chicago.

"These early results really speak to the importance of developing combination therapies," Beasley said. "Earlier animal results showed that using ADH-1 alone was not an effective treatment, but in combination with chemotherapy, the results, both pre-clinically and clinically, have been very exciting."

Malignant melanoma is increasing at a rate faster than any other cancer -- 60,000 new cases are expected to be diagnosed this year in the United States alone. When the growths spread beyond the primary site, the disease is rarely curable, and treatment is limited.

More information

The American Academy of Family Physicians has more about melanoma.



-- Kevin McKeever



SOURCE: Duke University Medical Center, news release, June 1, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Combo Kidney-Pancreas Transplant Boosts Survival in Diabetics
2. Breast cancer risk amplified by additional genes in combo with BRCA mutation
3. Celebrex-Lipitor combo may halt prostate cancer
4. Green Tea, Mushroom Extract Combo Slows Sarcomas
5. Hormone Combo May Provide Reversible Male Birth Control Tool
6. LG Electronics Debuts Unique Allergen-Reducing Steam Washer/Dryer Combo
7. Combo Treatment Ups Survival When Cancer Spreads to Abdominal Lining
8. MRI/PET scanner combo
9. Treatment Combo for Pancreatic Cancer Has Limited Benefit
10. Raised Breast Cancer Risk Persists After Combo HRT Stopped
11. Combo Treatment Best for Melanoma, Advanced Ovarian Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/20/2017)... ... ... to Moorwick”: the adventures of a young Scottish girl yearning to see the world. ... mother of five who used her time waiting for children to finish their extracurricular activities ... It was a way to give some meaning to the hours I waited for ...
(Date:9/20/2017)... ... 2017 , ... “Monique”: is the story of Monique, whose mother’s deteriorating ... published author, Colleen Crispi, has owned four beauty salons and written a book regarding ... estate and cooking. , “The doctor’s office was only three blocks away, and ...
(Date:9/19/2017)... ... September 19, 2017 , ... DeSola Group, a leading strategy, ... Flannery, to its strategic advisory and client development team. , In her ... clients across different industries to develop and implement market-justified strategies, modernize and transform ...
(Date:9/19/2017)... ... September 19, 2017 , ... Peter ... the President’s Malaria Initiative (PMI) Africa Indoor Residual Spraying (AIRS) Project , ... , The Innovation to Action Award, a USAID Catalyst Award, recognizes USAID ...
(Date:9/19/2017)... ... September 19, 2017 , ... CTNext , ... Innovation Awards (EIA), held this past Thursday night at The Space in Hamden. ... presented their innovative project ideas to a panel of judges for an opportunity ...
Breaking Medicine News(10 mins):
(Date:9/7/2017)... Ind. , Sept. 7, 2017  Zimmer Biomet ... in musculoskeletal healthcare, today announced that it will be ... Global Healthcare Conference at the Grand Hyatt hotel in ... 11, 2017 at 11:40 a.m. Eastern Time. ... via Zimmer Biomet,s Investor Relations website at http://investor.zimmerbiomet.com ...
(Date:9/6/2017)... , Sept. 6, 2017 NeuroRx, a clinical ... Suicidal Ideation and Behavior (ASIB), has been granted Fast Track ... sequential therapy of NRX-100 (ketamine HCl) followed by NRX-101 (D-cycloserine ... a pivotal trial of this sequential therapy targeting patients who ... 1 ...
(Date:9/5/2017)... 5, 2017  Just 18 months after its February ... to announce the appointment of three new senior people ... Dominic Jones-Phillips and James Wright ... Tammy Wynne joins ... access writers. She has over ten years, experience in ...
Breaking Medicine Technology: