Navigation Links
Combo Screening Doesn't Spot Early Ovarian Cancer
Date:3/20/2009

Even finding it early may not save lives, researchers say,,,,

FRIDAY, March 20 (HealthDay News) -- A screening regimen that combines ultrasound and a blood test to detect CA125, a marker for ovarian cancer, fails to discover the cancer in its early stages and often results in unnecessary surgery, a new study shows.

This finding contrasts with another recent study that found that these same two tests did find early cancer. Taken together, experts say these studies highlight the need to find an effective screening method for this deadly cancer, which is often called the "silent killer."

"The jury is still out on the efficacy of screening with CA125 and transvaginal ultrasound in terms of reducing the mortality rate of ovarian cancer," said lead researcher Dr. Edward Partridge, director of the University of Alabama Birmingham Comprehensive Cancer Center.

"In this study, we do not have mortality data on the screening versus the non-screening group, so no conclusions can be made of the impact of screening with CA125 and transvaginal ultrasound," he added.

This study only reports data on women who were screened, Partridge noted. "We learned that the positive predictive value for the combination of tests is pretty low -- in the 1 to 1.3 percent range," he said. "A substantial number of the tests are false positives."

In addition, screening with transvaginal ultrasound lead to a higher rate of surgery for positive findings than positive CA125, Partridge said. "Transvaginal ultrasound leads to more 'unnecessary' surgeries," he said.

And a high percentage of the cancers detected through screening were late-stage malignancies, Partridge said. "If you detect them at a late stage, it is unlikely that you are going to impact mortality," he said. "In order to affect mortality, one has to detect them at an earlier stage."

The report is published in the April issue of Obstetrics & Gynecology.

For the study, Partridge's team collected data on 34,261 women who underwent annual screening for CA125 and also had transvaginal ultrasound.

The researchers found that over the four years of screening, transvaginal ultrasound produced more positive findings for cancer than CA125 screening. In fact, CA125 positive tests decreased from 60 percent in the first year to 34 percent in the third year.

Of the 89 invasive ovarian cancers diagnosed, 60 were detected through screening. In addition, 72 percent of the screen-detected cancer were late-stage cancers, the researchers reported.

Partridge noted that even detecting cancer early may not have an impact on mortality. "In any screening trial, the ultimate test of its usefulness is does it impact mortality," he said.

Based on the findings of this study and the study published in the March 10 online edition of The Lancet Oncology, this screening method will not have any effect on mortality, Partridge said. "What we need is a more sensitive and specific screening test," he said.

In that study, a British research team found that screening was able to identify most women with cancer. The combination of the blood test and ultrasound found 90 percent of the cancers, while ultrasound alone found 75 percent of the cancers.

Almost 50 percent of all the cancers found were in an early stage (stage I or II), the researchers noted. And 48 percent of the more invasive ovarian cancers detected were designated as being stage I tumors. Usually, only 28 percent of ovarian cancers are identified in this early stage, the researchers pointed out.

Dr. David G. Mutch, the Ira C. and Judith Gall Professor of Obstetrics and Gynecology at Washington University, St. Louis, and author of an accompanying journal editorial, agreed there is no worthwhile screening test for ovarian cancer as yet.

"Patients who were screened presented at the same stage as they would have if they were unscreened," Mutch said. "There is no good screening test at this point."

Mutch added that there is no reason to screen for ovarian cancer in the general population at this point. "The prevalence of the diseases is so low, one in 2,500, and the specificity of the tests are so low, that we are going to operate on a lot of patients unnecessarily," he said.

More information

For more on ovarian cancer, visit the American Cancer Society.



SOURCES: Edward Partridge, M.D., director, University of Alabama Birmingham Comprehensive Cancer Center; David G. Mutch, M.D., Ira C. and Judith Gall Professor of Obstetrics and Gynecology, Washington University, St. Louis; April 2009, Obstetrics & Gynecology


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Radiation and drug combo helps boost efficacy of lung cancer treatment
2. Aerobic, Weight Training Combo Best Against Diabetes
3. New antibiotic drug combo to speed up treatment of tuberculosis
4. Drug Combo Helps Fight Marfan Syndrome
5. Drug Combo Blocks Pain Without Impairing Movement
6. Two-Drug Combo Fights Brain Tumors
7. CPR, Defibrillator Combo Boosts Cardiac Incident Survival
8. Drug Combo Boosts Multiple Myeloma Survival
9. Drug Combos Effective Against Rheumatoid Arthritis
10. Combo PET/CT Scan Helps Spot Breast Cancers Spread
11. Drug Combo With Antibiotic May Slow MS Progression
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Combo Screening Doesn't Spot Early Ovarian Cancer
(Date:10/13/2017)... ... October 13, 2017 , ... ProVest Insurance Group, ... Dallas, Miami, and Raleigh regions, is organizing an extended charity drive to benefit ... deadly chromosome abnormality. , After struggling since birth with several health challenges, T.J. ...
(Date:10/13/2017)... ... October 13, 2017 , ... The American Board of Family Medicine's (ABFM) ... and Chief Executive Officer, succeeding Dr. James C. Puffer upon his retirement. Dr. Newton ... until Dr. Puffer’s retirement at the end of 2018. Upon assuming the role of ...
(Date:10/13/2017)... ... ... Lori R. Somekh, founder of the Law Office of Somekh & Associates ... special needs planning attorneys. “Membership in ElderCounsel helps our office remain up to date ... elder law attorneys nationwide,” said Somekh. , ElderCounsel was founded by ...
(Date:10/13/2017)... New York, NY (PRWEB) , ... October 13, 2017 , ... ... most influential people in business to advocate for action towards gender equality at their ... 18,000 views from around the globe, and reached a social audience of over 3 ...
(Date:10/13/2017)... ... 2017 , ... Coveros, a leader in agile coaching services ... by the Center for Medicare and Medicaid Services (CMS). The Enterprise Agile Transformation ... Agile methodologies in a consistent and high value manner across CMS programs. Coveros ...
Breaking Medicine News(10 mins):
(Date:9/23/2017)... Janssen Biotech, Inc. (Janssen) announced today that ... U.S. Food and Drug Administration (FDA) for the Biologics ... treatment of moderately to severely active rheumatoid arthritis (RA). ... needed to further evaluate the safety of sirukumab in ... "We are disappointed ...
(Date:9/22/2017)... AVACEN Medical (AVACEN) announced that its CE-Marked ... those with the widespread pain associated with fibromyalgia in ... Essex, England commented, "I had ... no sleep at all, tremendous pain, with every movement ... [the AVACEN 100] enough, how this has and is ...
(Date:9/19/2017)... 2017   ZirMed Inc ., a recognized leader in ... it has been ranked #1 by its users for the ... 2017 User Survey. ZirMed was recognized as the top-ranked end-to-end ... medical centers over 200 beds and holds one of the ... survey history. ...
Breaking Medicine Technology: