Navigation Links
Combo PET/CT Scan Helps Spot Breast Cancer's Spread
Date:11/27/2007

Technique helps detect metastases earlier for women with inflammatory breast cancer, study finds

TUESDAY, Nov. 27 (HealthDay News) -- A technique that combines a PET scan with a CT scan can help spot the spread of inflammatory breast cancer, a rare but very aggressive form of the disease, researchers report.

"It is a quicker way of assessing everything," said lead researcher Dr. Selin Carkaci, assistant professor of radiology at The University of Texas M.D. Anderson Cancer Center in Houston. "Our results show it is very useful," she said.

Carkaci was expected to present her findings Monday at the annual meeting of the Radiological Society of North America, in Chicago.

According to the American Cancer Society, IBC accounts for 1 percent to 5 percent of all breast cancer cases in the United States. Often by the time it is discovered, it has spread. The five-year survival rate for those with IBC is 25 percent to 50 percent, according to the cancer society.

The new combo technology has been used in recent years for assessing other cancers as well, Carkaci noted. While the separate technologies of PET (positron emission tomography) and CT (computed tomography) have been in use since the early 1970s, their combined use came into practice only about eight years ago. Patients being treated at cancer centers across the United States should have access to this test, which is becoming more common, Carkaci said.

The technique she used is called FDG-PET/CT -- for "F-18 fluorodeoxyglucose positron emission tomography and computed tomography".

In a PET scan, a small amount of the radioactive drug F-18-labeled glucose is injected into the body. Fast-growing cancer cells feed on sugars and absorb it more quickly than do normal cells, Carkaci explained, so they "light up" on the images created by the PET scanner.

On the other hand, "the CT scanner takes a series of X-ray pictures, which are combined by a computer to create an extremely detailed image of the internal organs or other parts of the body," she said.

The scan gives great anatomical detail including the size, shape and location of the tumor. Together, the tests provide the most complete data on the tumor and its spread, Carkaci said.

In the study, doctors scanned 41 women newly diagnosed with inflammatory breast cancer. They found metastases in 20 patients, or 49 percent. They used biopsy or additional imaging to confirm the results when possible. Biopsy confirmation of metastases were available in four of 13 patients and additional imaging confirmation in nine.

"We found that FDG-PET/CT is 95 percent accurate in identifying distant metastases and 98 percent accurate in identifying regional lymph node metastases," Carkaci said.

"This [scanning] is done immediately after diagnosis, and then following the chemotherapy, to evaluate the response to treatment," she said.

The hope is to stop the cancer in its tracks.

One co-author, Dr. Homer Macapinlac, chair and professor of nuclear medicine at M.D. Anderson, reported being a consultant for General Electric Company and Siemens AG. Both companies produce scanners.

The study findings are "significant for the high rate of metastatic disease, with almost one half of the women with PET/CT able to identify the tumors at an early stage," said Dr. David Bluemke, professor of radiology and medicine and clinical director, MRI, Johns Hopkins Medical Institution, Baltimore.

"The data is very compelling for routine and early use of PET/CT for patients with inflammatory breast cancer," he said. "Although the study was small, the high accuracy rate appears promising for patients with this condition."

More information

To learn more about inflammatory breast cancer, visit the U.S. National Cancer Institute.



SOURCES: David Bluemke, M.D., Ph.D., professor, radiology and medicine, and clinical director MRI, Johns Hopkins Medical Institutions, Baltimore; Selin Carkaci, M.D., assistant professor, diagnostic radiology, University of Texas M.D. Anderson Cancer Center, Houston; Nov. 27, 2007, presentation, annual meeting of the Radiological Society of North America, Chicago


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Radiation and drug combo helps boost efficacy of lung cancer treatment
2. Aerobic, Weight Training Combo Best Against Diabetes
3. New antibiotic drug combo to speed up treatment of tuberculosis
4. Drug Combo Helps Fight Marfan Syndrome
5. Drug Combo Blocks Pain Without Impairing Movement
6. Two-Drug Combo Fights Brain Tumors
7. CPR, Defibrillator Combo Boosts Cardiac Incident Survival
8. Drug Combo Boosts Multiple Myeloma Survival
9. Drug Combos Effective Against Rheumatoid Arthritis
10. 18F-DG PET/CT can highly increase the detection of colorectal cancer
11. PET/CT Brings New Hope to Patients With Deadly Form of Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Combo PET/CT  Scan Helps Spot Breast Cancer's Spread
(Date:3/23/2017)... ... March 23, 2017 , ... The StayWell Company ... NCQA. The accreditation covers StayWell’s asthma, coronary artery disease, congestive heart failure, chronic ... organizations that have excellent programs for the delivery and improvement of disease management ...
(Date:3/23/2017)... , ... March 23, 2017 , ... ... families and businesses of the greater Fort Collins area, has unveiled a collaboration ... ongoing community involvement program. Donations to this worthy cause may now be made ...
(Date:3/23/2017)... ... , ... ?This conference will prominently feature 150+ Hospital and Health System Executive Speakers including: , ... , 43rd President of the United States of America: George W. Bush , ... Out of the Ring: Sugar Ray Leonard , JD, Chairperson, McGuireWoods LLP: Amber ...
(Date:3/23/2017)... ... March 23, 2017 , ... ... improve all aspects of people’s health and nutrition, announced its product Leyzene is ... , Natural Subsistence develops nutritional supplements that help people improve all aspects of ...
(Date:3/23/2017)... (PRWEB) , ... March 23, 2017 , ... The American ... 2017 marks the 40th Anniversary of ABQAURP’s dedication to Health Care Quality and Management ... who have contributed not only to the association, but also to the Health Care ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... On Wednesday, March 22, ... at 5,821.64, up 0.48%; the Dow Jones Industrial ... and the S&P 500 closed at 2,348.45, slightly ... out of nine sectors ended the day in ... on the following Medical Instruments & Supplies equities: ...
(Date:3/23/2017)... 2017 Piramal Pharma ... gibt die Ernennung von Stuart E. Needleman ... globalen Pharmazeutikkunden eine einmalige integrierte End-to-End-Serviceplattform an ... für das erfolgreiche Wachstum und die Umsetzung ... Herr Needleman dafür verantwortlich sein, alle globalen ...
(Date:3/23/2017)... 23, 2017 Merrimack Pharmaceuticals, Inc. (NASDAQ: ... patient in a Phase 1 study of MM-310 in ... encapsulates a novel taxane and targets the EphA2 receptor, ... of many major tumor types, including prostate, ovarian, bladder, ... of this study is an important step in evaluating ...
Breaking Medicine Technology: