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Combining diagnostic tests more accurate at predicting Alzheimer's
Date:12/10/2012

at may not be apparent to the naked eye. Hence, the data should not be taken to mean that imaging should be done in every patient; rather, it sought to capture the maximum potential information available in the images," Petrella said.

"Additional studies, including those looking at the cost effectiveness of these tests, are also needed to translate the most useful biomarkers into clinical practice."

Earlier this year, a multicenter study led by Doraiswamy found that another type of PET scan that tags amyloid plaques in the brains of people with Alzheimer's also helped predict the onset of the disease in those with mild cognitive impairment. Adding amyloid plaque imaging in future studies could supplement the tests used in this research, providing even more diagnostic information.

In addition to Petrella and Doraiswamy, study authors include Jennifer L. Shaffer, MD; Forest C. Sheldon, BS; Kingshuk Roy Choudhury, PhD; and R. Edward Coleman, MD (who died in June 2012) of the Department of Radiology at Duke University Medical Center. Vince D. Calhoun, PhD, of the Mind Research Network and the Department of Electrical and Computer Engineering at the University of New Mexico, also authored this research.


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Contact: Rachel Bloch Harrison
rachel.harrison@duke.edu
919-419-5069
Duke University Medical Center
Source:Eurekalert

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