Navigation Links
Combining 2 peptide inhibitors might block tumor growth
Date:3/14/2011

COLUMBUS, Ohio A new study suggests that combining two experimental anticancer peptide agents might simultaneously block formation of new tumor blood vessels while also inhibiting the growth of tumor cells.

This early test of the two agents in a breast cancer model suggests that the double hit can stifle tumor progression, avoid drug resistance and cause few side effects, say researchers at the Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James) who developed the agents and evaluated their effectiveness in laboratory and animal tests.

The scientists designed one of the agents to prevent human epithelial growth factor from interacting with HER-2, a molecule that marks a particularly aggressive form of breast cancer. The other inhibitor blocks the action of vascular endothelial growth factor (VEGF), which stimulates the growth of new blood vessels that tumors need to grow beyond a certain size.

The findings are described in two papers published online in the Journal of Biological Chemistry. One presents the development of a novel VEGF inhibitor; the other describes the HER-2 inhibitor and the preclinical testing of the two agents together.

"When we combined our peptide HER-2 inhibitor with the VEGF peptide that inhibits angiogenesis, we observed significant additive benefits in reducing tumor burdens in preclinical studies," says principal investigator Pravin Kaumaya, professor of obstetrics and gynecology, of molecular and cellular biochemistry, and of microbiology, and director of the division of vaccine development at the OSUCCC James.

The strategy of targeting both HER-2 and VEGF pathways should also discourage the development of drug resistance, Kaumaya says, because it simultaneously inhibits two pathways that are essential for tumor survival. "Combined peptide inhibitors might be appropriate in several types of cancer to overcome acquired resistance and provide clinical benefit," he adds.

Peptide inhibitors consist of short chains of amino acids (the VEGF inhibitor is 22 amino acids long) that conform in shape to the active site of the target receptor. In addition, Kaumaya engineered the VEGF peptide to be resistant to protease, an enzyme, thereby increasing its efficacy. The shape of the peptide HER-2 inhibitor engineered by Kaumaya and his colleagues, for example, is highly specific for the HER-2 receptor. It physically binds to the receptor, which prevents another substance, called epithelial growth factor, from contacting the receptor and stimulating the cancer cells to grow.

Other categories of targeted drugs in clinical use are humanized monoclonal antibodies and small-molecule TKI inhibitors. Both groups are associated with severe side effects and are very expensive, Kaumaya says. "We believe peptide inhibitors offer non-toxic, less-expensive alternatives to humanized monoclonal antibodies and small-molecule inhibitors for the treatment of solid tumors, with the potential for improved efficacy and better clinical outcomes," he says.


'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Related medicine news :

1. Visual prostheses: Symposium to explore combining functional endpoints
2. Study provides molecular rationale for combining targeted agents to treat breast cancer
3. Combining radiation therapy, chemotherapy safely treats head and neck cancer patients
4. Combining medication and psychosocial treatments may benefit patients with early-stage schizophrenia
5. Combining resistance and endurance training best for heart health
6. New techniques for stapling peptides could spur development of drugs for cancer
7. Peptide delivers 1-2 punch to breast cancer in pre-clinical study
8. Peptide being tested to treat atherosclerosis inhibits ovarian cancer growth
9. Cosmetic Peptides that Significantly Reduce Length and Depth of Wrinkles: Janet Sartin Introduces Advanced Anti-Wrinkle Peptide Serum for All Skin Types
10. Current smokers with early rheumatoid arthritis less responsive to TNF inhibitors, methotrexate
11. JAK inhibitors producing significant response in myelofibrosis patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2017)... ... 22, 2017 , ... University Orthopedics (UOI) today announced the ... Hand, Upper Extremity and Microvascular Surgery at Newport Hospital. Dr. Bragdon specializes in ... and Hand Surgery. , As the leader of comprehensive orthopedic care in ...
(Date:3/22/2017)... ... 22, 2017 , ... Last year, 43 million gallons of surplus milk was ... While excess dairy can be caused by several factors, one pharmaceutical company CEO ... to properly digest lactose, a sugar found in milk and milk products. ...
(Date:3/22/2017)... ... March 22, 2017 , ... The Carballo ... Jersey and the New York metropolitan region, is embarking on a cooperative charity ... families. , At present, more than two and a half million children in ...
(Date:3/22/2017)... ... 22, 2017 , ... The Vanderbeck Agency, a Long Island firm providing insurance, ... embarking on a combined charity effort with the Great Neck Breast Cancer Coalition to ... the Great Neck Breast Cancer Coalition has worked to support breast cancer patients in ...
(Date:3/22/2017)... ... March 22, 2017 , ... ... services to regional families and business owners, is joining the Teen Recovery Solutions ... in the area. , A growing number of Oklahoma teens and adolescents face ...
Breaking Medicine News(10 mins):
(Date:3/22/2017)... , 22. März 2017   ... und weltweit tätige Anbieter von Produkten und ... den Erwerb von EPL Archives Inc. bekannt, ... der Kunden im kompletten Zyklus regulierter Forschung, ... von Proben, Speicherung von Dokumenten und Zusatzdienstleistungen ...
(Date:3/22/2017)... 2017 TapImmune, Inc. (NASDAQ: ... development of innovative peptide and gene-based immunotherapeutics for ... announced that it will participate in two upcoming ... Glynn Wilson , Chairman and CEO of TapImmune, ... clinical pipeline and partnering opportunities for its proprietary ...
(Date:3/22/2017)... 22, 2017 A new independent study ... the proven ultraviolet-C (UV-C) disinfection solution of choice ... Published in the March issue ... , the peer-reviewed study of UV-C disinfection systems ... General Hospital and Rochester General Hospital. According to ...
Breaking Medicine Technology: