Navigation Links
Combined physical and genetic map finds cancer's 'ignition key'
Date:5/5/2008

egion on chromosome 13, which they knew harbored the tumor-suppressor RB1, for high-resolution genetic analysis to identify candidate genes affecting RB1 by using single-nucleotide polymorphisms (SNPs) as markers. SNPs are points in the genome that vary by a single DNA chemical building block or nucleotide.

They examined 92 SNPs mapping to a region around the RB1 gene in 84 paired samples of bladder tumors and blood DNA. This high-resolution genetic analysis pointed to the same section of the chromosome that whole organ histologic and genetic mapping had identified with expansion of abnormal cells.

Two genes in the region were found to give cells an initial minimum genetic advantage needed to grow into cancer.

A neighboring gene called ITM2B was found to be silenced by methylation, which is the connection of a methyl chemical group to portions of the gene that shuts it down. In bladder cancer tumors and cancer cell lines, this gene was methylated 40 percent of the time.

A gene known as P2RY5 located inside a portion of the RB1 gene was affected by a number of single-nucleotide changes. A case-control study of one of the genes variant forms was conducted using blood DNA from 790 bladder cancer patients and 712 controls matched for age and gender. The specific variation was present in 2.78 percent of patients and every patient with the variation who also smoked developed bladder cancer.

The forerunner genes identified in bladder cancer were analyzed for their expression, methylation and sequence in 62 cell lines derived from major groups of common cancers. Of the cell lines tested, forerunner gene expression was reduced in 63 percent of the cases and ITM2B was methylated in 42 percent.

While forerunner genes were downregulated in lung, breast, blood and pediatric malignancies, they were strongly expressed in colon and liver cancers. This makes sense, the researchers note, because those two cancers do not rely on inactivat
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. Home Oxygen Leaders Warn That Competitive Bidding Program Reductions Combined with Other Pending and Proposed Cuts Are Unsustainable and Unpredictable
2. USC researchers find benefit for lymphoma patients in combined PET-CT scanning
3. Combined stenting and photodynamic therapy improves survival in late stage liver cancer patients
4. AT4 wireless and Ekahau Partner to Deploy Combined Asset and Staff Tracking Solution for Hospitals
5. Combined radiation seed, chemotherapy wafer implants show promise in treating cancerous brain tumors
6. Combined HRT increases risk of lobular breast cancer fourfold after just 3 years of use
7. Combined Boards Provide Better Care to More Clients More Efficiently
8. Phase III Trial of VELCADE(R) (Bortezomib) for Injection Showed Dramatic Fourfold Increase in Complete Remission Rates When Combined With the Most Commonly Used U.S. Regimen in Front-Line Multiple Myeloma
9. Study Finds New Version of QIAGENs HPV Test for Developing Countries Could Reduce Risk of Cervical Cancer by More than Half When Combined With Appropriate Treatment
10. Common Medications Could Cause Physical Impairment in the Elderly
11. Commonly used medications associated with impaired physical function in older adults
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... September 23, 2014 Trevera provides ... market. Included are Oracle Managed Services , ... supports all versions of Oracle E-Business Databases ... , Trevera has announced a significant enhancement ... need help with their software technology management, project ...
(Date:9/23/2014)... September 23, 2014 The Sloane ... in Singapore and Malaysia providing advanced aesthetic dermatology ... powder to its impressive skin care repertoire. Specially ... skin’s defences against the evil forces of aging, ... glow simultaneously, this new addition is revolutionizing the ...
(Date:9/23/2014)... The University of North Carolina ... In the Piedmont Triad, announced today that Dr. ... the Center for Translational Biomedical Research (CTBR). Zhang, ... after nearly a decade at the U.S. Department ... Division. , “Our goal is to build ...
(Date:9/23/2014)... Dennis Thompson HealthDay ... -- Coupled with worldwide marches demanding action on climate ... altered weather patterns in the United States may soon ... arrest and other heat-related illnesses are expected to increase ... lead author Dr. Jonathan Patz, director of the Global ...
(Date:9/23/2014)... Randy Dotinga HealthDay Reporter ... using cholesterol-lowering drugs while in the hospital for a hemorrhagic ... more than four times more likely to survive than people ... People taking the commonly used drugs known as statins ... or to a rehabilitation facility, the study reports. When ...
Breaking Medicine News(10 mins):Health News:Trevera, Inc adds Management Support to Services 2Health News:Trevera, Inc adds Management Support to Services 3Health News:The Sloane Clinic™ introduces a revolutionary BB powder to its impressive skin care repertoire 2Health News:The Sloane Clinic™ introduces a revolutionary BB powder to its impressive skin care repertoire 3Health News:The Sloane Clinic™ introduces a revolutionary BB powder to its impressive skin care repertoire 4Health News:Former Department of Energy Scientist Joins UNCG as Co-director of Biomedical Research Center 2Health News:Health Woes to Worsen Due to Climate Change, Study Warns 2Health News:Health Woes to Worsen Due to Climate Change, Study Warns 3Health News:Cholesterol-Lowering Drugs May Help After Certain Strokes 2Health News:Cholesterol-Lowering Drugs May Help After Certain Strokes 3
... finds dexmedetomidine caused less delirium, , , TUESDAY, Dec. ... on patients who are hooked up to mechanical ... worry that too much sedation might slow down ... , Now, researchers report that by substituting a ...
... January 7, Discovery Health Presents Five Nights of Active, Viewing ... ... FIT TO LIVE -, SILVER SPRING, Md., Dec. 11 ... annual,weight loss and general wellness campaign-launches with a four-part,television event following ...
... ANGELES, Dec. 11 AIDS Healthcare,Foundation (AHF) today ... Mike Huckabee, for his stubbornness and,recent failure to ... Senate campaign in which he called for people ... population. At the time, Huckabee,told Associated Press in ...
... Calls on Every Candidate from Every Party to ... WASHINGTON, Dec. 11 AIDS Action released a,statement ... rewrite,his HIV/AIDS platform to ensure that the policies ... and end stigma against people,living with HIV. "Governor ...
... combination of bortezomib (Velcade) and two other drugs is ... diagnosed with multiple myeloma, a team headed by Dana-Farber ... the American Society of Hematology. , The three-pronged regimen ... as Rev/Vel/Dex has achieved an overall response rate ...
... quality of life, researchers say , , TUESDAY, Dec. 11 ... constraint-induced movement therapy, some stroke patients can have significant ... a better quality of life, a new study finds. ... the less-affected hand. This forced them to use their ...
Cached Medicine News:Health News:Newer Sedative Might Help Patients on Ventilators 2Health News:Newer Sedative Might Help Patients on Ventilators 3Health News:Overweight Twins Battle the Bulge and Gain A New Lease on Life in National Body Challenge: Twins Edition on Discovery Health 2Health News:Overweight Twins Battle the Bulge and Gain A New Lease on Life in National Body Challenge: Twins Edition on Discovery Health 3Health News:Overweight Twins Battle the Bulge and Gain A New Lease on Life in National Body Challenge: Twins Edition on Discovery Health 4Health News:Huckabee's Defense of Earlier, Alarmist AIDS Stance Shows Unsuitability for Presidency, Says AHF 2Health News:AIDS Action Calls on Huckabee to Follow HIV/AIDS Science 2Health News:3-drug combination 'extremely promising' as first-line therapy for multiple myeloma 2Health News:Stroke Rehab Technique Has Lasting Results 2Health News:Stroke Rehab Technique Has Lasting Results 3
(Date:9/23/2014)... 23, 2014 Ultrasound devices enable physicians ... order to diagnose diseases and also these devices ... while performing surgeries. This report studies the global ... as product type, technologies, applications and the major ... on the product type has been segmented as: ...
(Date:9/23/2014)... 2014   LabStyle Innovations Corp . (OTCQB: ... today announced that it has closed a $4.2 ... preferred stock and warrants.  No placement agent was ... LabStyle expects to secure net proceeds of approximately ... LabStyle intends to use the net proceeds from ...
(Date:9/23/2014)... 2014 Report Details Kinase ... R&D and predicted revenues Do you want to ... the latest analysis for those cancer treatments. There ... revenue forecasts. Visiongain,s new report shows you ... and related technology. There avoid missing out in ...
Breaking Medicine Technology:Ultrasound Devices Market (By Product Type, By Technology and By Application - Obstetrics and Gynecology, Cardiovascular, Abdominal and Others) - Global Industry Analysis, Size, Share, Growth, Trends & Forecast, 2013 - 2019 2Ultrasound Devices Market (By Product Type, By Technology and By Application - Obstetrics and Gynecology, Cardiovascular, Abdominal and Others) - Global Industry Analysis, Size, Share, Growth, Trends & Forecast, 2013 - 2019 3LabStyle Innovations Closes $4.2 Million Non-Brokered Private Placement Financing 2LabStyle Innovations Closes $4.2 Million Non-Brokered Private Placement Financing 3LabStyle Innovations Closes $4.2 Million Non-Brokered Private Placement Financing 4LabStyle Innovations Closes $4.2 Million Non-Brokered Private Placement Financing 5Kinase Inhibitors for Treating Cancer: Industry Analysis, R&D Trends and World Market Forecasts 2014-2024 2Kinase Inhibitors for Treating Cancer: Industry Analysis, R&D Trends and World Market Forecasts 2014-2024 3Kinase Inhibitors for Treating Cancer: Industry Analysis, R&D Trends and World Market Forecasts 2014-2024 4Kinase Inhibitors for Treating Cancer: Industry Analysis, R&D Trends and World Market Forecasts 2014-2024 5
... MENLO PARK, Calif. , July 12 Crux Biomedical® ... of medical device and diagnostic companies. The survey, conducted by Medical Device ... issue. The purpose of the survey was to identify firms that have ... their respective products. , , ...
... OKLAHOMA CITY , July 12 For the second consecutive ... receive its prestigious R&D 100 Award.  Orthocare Innovations received this award for ... function of persons who have experienced lower limb loss, injury or disease. ... (Logo:   http://photos.prnewswire.com/prnh/20100712/DA33752LOGO ) ...
Cached Medicine Technology:Crux Biomedical Named One of Top 50 Companies to Watch 2Orthocare Innovations Receives Prestigious R&D 100 Award for Novel Web-Based Rehabilitation Outcomes Assessment System 2
Heine Beta 200 Streak Retinoscope 2.5v...
System, English (Continental cord), 230 VAC....
Micro-mini fiber optic light....
Xenon technology achieves a higher efficiency than halogen light sources. Consequently they provide more light....
Medicine Products: