Navigation Links
Combined drug therapy to treat TB and HIV significantly improves survival
Date:2/25/2010

Initiating antiretroviral therapy (ART) during tuberculosis therapy significantly reduced mortality rates by 56 percent in a randomized clinical trial of 642 patients co-infected with HIV and tuberculosis. The study, which provides further impetus for the integration of TB and HIV services, lays to rest the controversy on whether co-infected patients should initiate ART during or after TB treatment. Findings are published in the February 25th issue of The New England Journal of Medicine.

Tuberculosis is the most common opportunistic disease and the most frequent cause of death in patients with HIV infection in developing countries, and the number of patients with co-infection continues to grow rapidly.

"Despite World Health Organization(WHO) guidelines supporting concomitant treatment of the two diseases and urging more aggressive management initiation of antiretroviral therapy, treatment often has been deferred until completion of tuberculosis therapy because of concern about potential drug interactions, overlapping side effects, a high pill burden, and programmatic challenges," said Salim S. Abdool Karim, MD, PhD, professor of clinical epidemiology at Columbia University's Mailman School of Public Health, pro vice-chancellor (research) at the University of KwaZulu-Natal in Durban, South Africa, and principal investigator of the study.

The new study, called the Starting Antiretroviral Therapy at Three Points in Tuberculosis (SAPiT), was designed to determine the optimal time to initiate antiretroviral therapy in patients with HIV and tuberculosis co-infection who were receiving tuberculosis therapy. The trial was conducted at the eThekwini HIVtuberculosis clinic, operated by the Centre for the AIDS Programme of Research in South Africa (CAPRISA) in Durban, South Africa.

Of the 642 patients in the trial, 429 were in the combined integrated-therapy groups who initiated ART during TB treatment as compared with the 213
'/>"/>

Contact: Stephanie Berger
sb2247@columbia.edu
212-305-4372
Columbia University's Mailman School of Public Health
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Combined mammography and breast MRI useful for some high-risk women
2. Green tea chemical combined with another may hold promise for treatment of brain disorders
3. Holistic and Western Medicine Combined Can Fight Cancer
4. UnitedHealthcare To Offer Seniors Hispanic-Centered Medicare Education Seminars Combined With a Latin-Themed Fitness Program
5. Report Finds Alzheimer's Killing More People Than Breast And Prostate Cancer Combined
6. Research: People With Type 2 Diabetes Improved Muscular Strength and Exercise Capacity Through Physical Therapist Exercise Counseling Combined With Fitness Center Exercise Training
7. Study finds promise in combined transplant/vaccine therapy for high-risk leukemia
8. FDA Approves LIVALO(R) for Primary Hypercholesterolemia and Combined Dyslipidemia
9. Recently Released Data from the National Survey of Childrens Health Reports That Autism Now Affects 1% of Children and is More Common Than Childrens Cancer, Diabetes, and AIDS Combined.
10. Hard To Treat Diseases (HTDS) Clinical Trial Update on Therapeutic effects of Combined Treatment With Ribavirin And Tiazofurin
11. Childrens Hospital of Philadelphia Earns Highest Combined US News Score in 10 Specialties Ranked by U.S. News & World Report
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... September 02, 2014 The Dream2Walk Foundation along ... on Sept. 14th, 2014 during Spinal Cord Injury Awareness Month ... Lynn England, and Chuck Ligon. Linear Automotive will be there ... show. , Doors open at 2pm. The car show is ... one free pass to the concert. There will be trophies ...
(Date:9/2/2014)... -- Melatonin supplements did not reduce delirium in seniors ... found. Many older hospital patients experience the sudden, ... their normal sleep-wake cycle. A lack of the hormone ... but there has been little research into whether melatonin ... 378 patients, average age 84, who had hip fracture ...
(Date:9/2/2014)... the levels of sex hormones in patients, blood may identify ... rhythm disorder that is fatal in 95 percent of patients. ... journal Heart Rhythm , shows that lower levels of ... who had a sudden cardiac arrest. Higher levels of estradiol, ... chances of having a sudden cardiac arrest in both men ...
(Date:9/2/2014)... Waco, TX (PRWEB) September 02, 2014 When ... any time day or night, leaving behind a path of ... tornado occurrences with an average of 1,253 tornadoes per year. ... be prepared in case a tornado strikes., , ... cellar, or interior room in your home with no windows ...
(Date:9/2/2014)... York, NY (PRWEB) September 02, 2014 ... VisitandCare.com , was designed to help doctors manage ... practices to boost patient conversion rates and clink revenue. ... a 60 percent increase in sales revenue and a ... one-of-a-kind CRM software in their own healthcare practices. , ...
Breaking Medicine News(10 mins):Health News:Gas Monkey Hosts Concert in Dallas Benefiting Dream2Walk Foundation with Linear Automotive 2Health News:Study links sex hormone levels in the blood to risk of sudden cardiac arrest 2Health News:Act Quickly in Case of Tornado: Rainbow International® Offers Tips on How to Be Prepared for a Tornado 2Health News:Doctors Abroad Using VisitandCare.com Patient Management Software Report 60% Increase in Revenue 2Health News:Doctors Abroad Using VisitandCare.com Patient Management Software Report 60% Increase in Revenue 3Health News:Doctors Abroad Using VisitandCare.com Patient Management Software Report 60% Increase in Revenue 4
... immediately call off their 20-day agitation against a new reservation ... court - which accepted a petition from the striking medicos ... its orders are not implemented. ,"We direct that ... should be called off forthwith," a vacation bench comprising Justice ...
... According to a research it has been found that in ... mandatory for everyone to maintain a regular exercise program//. ... the major of cause of death in men, which results ... which cholesterol-laden plaques build up in the arteries. As the ...
... According to a recent survey the young adults between the ... among the uninsured. The report by the Commonwealth Fund, a ... claim that in 2004, nearly 14 million Americans between 19 ... of 2.5 million since the year 2000. ,The ...
... falling standards of cleanliness despite Government promises to clean ... in 2002, only 52 percent reported about clean wards. ... very clean, but only 46 percent this year. Contradicting ... levels of general satisfaction with the health service. ...
... spread and growing variety of unregulated tobacco products, the ... broader regulation // to prevent more than five million ... agency also called for anti-tobacco programmes, especially aimed at ... apparently increasing. ,Tobacco use, it finds, also continued ...
... incidence of HIV/AIDS is declining in the western Indian state ... , Karnataka and Andhra Pradesh because of the proactive measures ... in the country, especially in the north, it is rising, ... released Tuesday, said that overall two-thirds of the people living ...
Cached Medicine News:Health News:More Number Of Younger Americans Lack Health Insurance 2
(Date:9/2/2014)...  Edison Nation Medical, the premier healthcare innovation ... Association for Respiratory Care ( AARC ), the ... Nation Medical, which brings 12+ years experience working ... innovation ideas, will work with AARC to assist ... respiratory therapists in bringing their product innovation ideas ...
(Date:9/2/2014)... , Sept. 2, 2014  EMD Serono, Inc., a ... , announced today that Drew Young has ... Immunology. In this capacity, he will be responsible for ... Immunology franchise, including future products.   Bringing more ... marketing and sales efforts at pharmaceutical and biotech companies, ...
(Date:9/2/2014)... 2014 Actavis plc (NYSE: ACT ... Administration (FDA) has accepted for filing Actavis, New Drug ... treatment of diarrhea and abdominal pain in men and ... NDA for eluxadoline has been granted priority review status ... "The NDA filing of eluxadoline marks ...
Breaking Medicine Technology:Edison Nation Medical and AARC Team Up To Promote Innovation in Respiratory Care 2Edison Nation Medical and AARC Team Up To Promote Innovation in Respiratory Care 3EMD Serono Appoints Drew Young to Senior Vice President, Neurology and Immunology 2EMD Serono Appoints Drew Young to Senior Vice President, Neurology and Immunology 3EMD Serono Appoints Drew Young to Senior Vice President, Neurology and Immunology 4Actavis Announces FDA Acceptance for Filing of NDA for Eluxadoline 2Actavis Announces FDA Acceptance for Filing of NDA for Eluxadoline 3Actavis Announces FDA Acceptance for Filing of NDA for Eluxadoline 4
... (Nasdaq:  ARAY), a global leader in the field of ... institutions using CyberKnife radiosurgery in breast cancer treatment. These ... Fox Chase Cancer Center, will be presented at the ... Oncology (ASTRO) in San Diego from October 31 to ...
... 2010 Boehringer Ingelheim Pharmaceuticals, Inc. announced today results ... combination of two oral hepatitis C virus (HCV) compounds, ... BI 207127, with ribavirin reduced viral load below the ... The regimen did not include interferon through the first ...
Cached Medicine Technology:CyberKnife Radiosurgery for Early-Stage Breast Cancer 2CyberKnife Radiosurgery for Early-Stage Breast Cancer 3CyberKnife Radiosurgery for Early-Stage Breast Cancer 4CyberKnife Radiosurgery for Early-Stage Breast Cancer 5CyberKnife Radiosurgery for Early-Stage Breast Cancer 6Results of Boehringer Ingelheim Oral Hepatitis C Protease Inhibitor and Polymerase Inhibitor Combination Phase Ib Trial Shows Rapid Viral Response Without Use of Pegylated Interferon 2Results of Boehringer Ingelheim Oral Hepatitis C Protease Inhibitor and Polymerase Inhibitor Combination Phase Ib Trial Shows Rapid Viral Response Without Use of Pegylated Interferon 3Results of Boehringer Ingelheim Oral Hepatitis C Protease Inhibitor and Polymerase Inhibitor Combination Phase Ib Trial Shows Rapid Viral Response Without Use of Pegylated Interferon 4
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: