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Combination vaccines okay for infants, study shows
Date:10/3/2007

ealthy 2-month-olds were enrolled at 22 sites nationwide. Each infant was randomly assigned to one of three trial groups:

1. Combination Vaccine Group, which received three vaccines the combination vaccine (DTaP-HepB-IPV, or brand name Pediarix), a second vaccine to protect against HiB, and a third, PCV-7 (or brand name Prevnar).

2. Separate Vaccine Group, which received five independent vaccines: DTaP, (for diphtheria, tetanus and whooping cough), HepB (for hepatitis B), IPV (for poliovirus), HiB, and PVC-7.

3. Staggered Vaccine Group that was identical to the Combination Group, save that PCV-7 vaccines were delayed by two weeks at every appointment, thereby demanding a total of six pediatric office visits, instead of three.

Blood samples were collected before the study began, and again when infants were 7 months, to test for a robust immune response to each disease-trigger.

Parents were provided a diary and asked to record temperatures, general symptoms such as fussiness, irritability or loss of appetite, and local injection site symptoms such as pain or swelling.

Results

Minor symptoms were more common in the Combination Vaccine Group; however higher fevers and more severe shot site reactions were not significantly more likely to occur in infants in any of the three groups.

For example, swelling and pain were significantly higher at the injection site of the combination vaccine, but Pichichero said that is to be expected, given that there are more ingredients in that single shot (vaccines are made from killed or modified forms of bacteria or viruses, or only pieces or products of the germs). But, he added, it was noteworthy that at no time did any local symptoms (swelling, redness, pain) lead to an infant obtaining a medical attention visit.

Vaccine opponents may liken the process of the body processing simultaneous vaccines to a computer running too many applications; the machine gro
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Contact: Becky Jones
rebecca_jones@urmc.rochester.edu
585-275-8490
University of Rochester Medical Center
Source:Eurekalert

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