Navigation Links
Combination vaccines okay for infants, study shows
Date:10/3/2007

A University of Rochester study brings relief to new parents who, while navigating a jam-packed childhood vaccine schedule, can expect to soothe their newborn through as many as 15 pokes by his or her six-month checkup.

The study, recently published in The Journal of Pediatrics, shows that no efficacy or safety is compromised when clinicians administer a new combination vaccine that streamlines the process in effect, tripling up three of the recommended shots to reduce the poke total from five to three, at each of three bimonthly, well-child checkups.

Only more immunizations will enter the schedule, said Michael Pichichero, M.D., professor of Microbiology/Immunology, Pediatrics and Medicine at the University of Rochester and the studys lead author. Coupling or tripling of these vaccines is increasingly important, as this streamlining helps to promote parent compliance, timely vaccination and fewer administration errors.

The study overturns findings (and fears) from a previous study that suggested problems when two specific vaccines were given at the same time Pediarix, a combination of vaccines that guard against diphtheria, tetanus, whooping cough, hepatitis B and poliovirus, and Prevnar, which protects against 76 strains of Streptococcus pneumonia. The earlier studies found that when the vaccines were co-administered, a suboptimal immune response was produced against whooping cough, and more uncomfortable reactions, such as swelling at the injection site, could be expected.

Both Pediarix and Prevnar are recommended for administration at 2-, 4- and 6-month checkups; Prevnar was approved in 2000, shortly before the licensure of Pediarix.

This newest study unseated both early reservations, showing that the combination vaccine was in fact just as safe and as immunogenic as separate shots, even in the midst of other vaccines in the schedule, Pichichero said.

Study Details

A total of 575 healthy 2-month-olds were enrolled at 22 sites nationwide. Each infant was randomly assigned to one of three trial groups:

1. Combination Vaccine Group, which received three vaccines the combination vaccine (DTaP-HepB-IPV, or brand name Pediarix), a second vaccine to protect against HiB, and a third, PCV-7 (or brand name Prevnar).

2. Separate Vaccine Group, which received five independent vaccines: DTaP, (for diphtheria, tetanus and whooping cough), HepB (for hepatitis B), IPV (for poliovirus), HiB, and PVC-7.

3. Staggered Vaccine Group that was identical to the Combination Group, save that PCV-7 vaccines were delayed by two weeks at every appointment, thereby demanding a total of six pediatric office visits, instead of three.

Blood samples were collected before the study began, and again when infants were 7 months, to test for a robust immune response to each disease-trigger.

Parents were provided a diary and asked to record temperatures, general symptoms such as fussiness, irritability or loss of appetite, and local injection site symptoms such as pain or swelling.

Results

Minor symptoms were more common in the Combination Vaccine Group; however higher fevers and more severe shot site reactions were not significantly more likely to occur in infants in any of the three groups.

For example, swelling and pain were significantly higher at the injection site of the combination vaccine, but Pichichero said that is to be expected, given that there are more ingredients in that single shot (vaccines are made from killed or modified forms of bacteria or viruses, or only pieces or products of the germs). But, he added, it was noteworthy that at no time did any local symptoms (swelling, redness, pain) lead to an infant obtaining a medical attention visit.

Vaccine opponents may liken the process of the body processing simultaneous vaccines to a computer running too many applications; the machine grows slow, and the programs, one by one, begin to terminate, Pichichero said. But those fears are unfounded; we have found no evidence that a childs body is at any point approaching a maximum threshold as far as learning to produce immune responses.

When you administer more vaccines, you expect more symptoms, more fevers, he said. Fever, swelling, redness are all indicators that the vaccine is working, that the body is busy creating the right immunity to prevent disease.

So long as they are mild, they pale in comparison to benefits of convenience to the parent, the fewer number of pokes to the infant, and of course, the severity of the diseases we are preventing, he said.

Perhaps most importantly, the study showed the Combination Vaccine Group enjoyed at least as good immunogenicity as the Separate and Staggered Groups, for all criteria including the criterion for protecting against whooping cough, for which previous, smaller-scale studies had yielded inconsistent results.

If pediatricians were holding out on making the switch to a combined vaccine for fear that its protection might be inferior, they no longer need be concerned, Pichichero said. It seems the clinical relevance of any previously observed differences with regard to whooping cough immunity have been dispelled.


'/>"/>

Contact: Becky Jones
rebecca_jones@urmc.rochester.edu
585-275-8490
University of Rochester Medical Center
Source:Eurekalert

Related medicine news :

1. Consensus on "Combination Therapy" for Breast Cancer
2. Smoking and Breast Cancer - A Deadly Combination
3. The bad combination
4. Drug Combinations May Boost Stroke Risk
5. Combination therapy to treat breast cancer
6. Combination regime may work against prostate cancer
7. New Drug Combination Found To Improve Memory in Alzheimer’s Patient
8. A Combination Of Drugs Effective In The Treatment Of Hormone-Refractory Prostate Cancer
9. Combination Therapy Effective In Improving Lung Cancer Survival
10. Combination Therapy Found To Improves Stroke Recovery
11. Combination Therapy Found To Be More Effective In Treating Brain Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is ... Road To Recovery® program to drive cancer patients to and from their cancer treatments. ... the highest quality of life and ongoing independence. Getting to and from medical ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... People across ... in Genome magazine’s Code Talker Award, an essay contest in which patients and their ... award to be presented at the 2016 National Society of Genetic Counselors (NSGC) Annual ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute Beauty Network, affiliated ... Weintraub as a prominent plastic surgeon and the network’s newest partner. , ... most handsome men, look naturally attractive. Plastic surgery should be invisible.” He stands ...
(Date:6/24/2016)... ... June 24, 2016 , ... Strategic ... Frederick area economy by obtaining investment capital for emerging technology companies. SCP ... that have already resulted in more than a million dollars of capital investment ...
(Date:6/24/2016)... ... ... Venture Construction Group (VCG) sponsors Luke’s Wings 5th Annual ... Country Club at 1201 Rockville Pike, Rockville, Maryland, 20852. The event raised funds ... been wounded in battle and their families. Venture Construction Group is a 2016 Silver ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Research ... "Pharmaceutical Excipients Market by Type (Organic Chemical (Sugar, Petrochemical, ... (Oral, Topical, Coating, Parenteral) - Global Forecast to 2021" ... The global pharmaceutical excipients market is ... a CAGR of 6.1% in the forecast period 2016 ...
(Date:6/23/2016)... Research and Markets has announced the addition of the ... to 2022" report to their offering. ... financial data derived from varied research sources to present unique ... on the market during the next five years, including a ... markets, regional and country level analysis. The report provides a ...
(Date:6/23/2016)... 2016 Bracket , a leading clinical trial ... clinical outcomes platform, Bracket eCOA (SM) 6.0, at the ... – 30, 2016 in Philadelphia , Pennsylvania.  ... Assessment product of its kind to fully integrate with RTSM, ... eCOA 6.0 is a flexible platform for electronic clinical outcomes ...
Breaking Medicine Technology: