Navigation Links
Combination therapy shows positive response for children with ADHD
Date:1/9/2012

Washington D.C., January 9, 2012 - While pharmacologic agents have a demonstrated efficacy in children with Attention-deficit/hyperactivity disorder (ADHD), some children have suboptimal response to a single pharmacologic agent. A recent study by Dr. Timothy E. Wilens and colleagues, published in the January 2012 issue of the Journal of the American Academy of Child and Adolescent Psychiatry (JAACAP), is the first randomized placebo-controlled trial designed to assess efficacy and safety of guanfacine extended release (GXR) as an adjunct to psychostimulants in children and adolescents diagnosed with ADHD who had a suboptimal response to a psychostimulant alone.

As reported in the article "A Controlled Trial of Extended-release Guanfacine and Psychostimulants for Attention-deficit/hyperactivity disorder," Wilens and colleagues conducted a nine week multicenter, double-blind, placebo-controlled, dose-optimization study, with participants in 59 study sites who continued their stable dose of psychostimulant given in the morning and were randomized to receive GXR in the morning, GXR in the evening, or placebo.

For both morning and evening administration of GXR, subjects receiving GXR plus a psychostimulant showed significantly greater improvement from baseline to endpoint, as measured by the ADHD-Rating Scale IV total score, compared with subjects receiving placebo plus a psychostimulant. In particular, the inattention subscale rating and the hyperactivity/ impulsivity subscales of the ADHD-RS-IV showed significantly greater improvements from baseline in subjects receiving GXR with a psychostimulant compared with subjects receiving placebo plus psychostimulant. Significant benefits of adjunctive administration were observed whether GXR was administered in the morning or evening. No new safety signals emerged after adjunctive administration of GXR with psychostimulants compared with psychostimulants alone.

Reflecting on their research findings, Wilens and colleagues stated, "The results of this study support the hypothesis that adjunctive administration of the selective alpha2A-adrenoceptoragonist, GXR, to a psychostimulant in subjects with suboptimal response to psychostimulants reduces ADHD symptoms over placebo with a psychostimulant."


'/>"/>

Contact: Mary Billingsley
mbillingsley@jaacap.org
202-966-7300 x105
Elsevier
Source:Eurekalert

Related medicine news :

1. Severe alcoholic hepatitis: An effective combination of 2 treatments
2. Combination epigenetic therapy clinical trial results
3. NYUCN receives $2.8 million NIH/NIAID grant to study combination HIV prevention for Kenyan youth
4. Combination of available tests helps predict Alzheimers disease risk
5. Combination therapies for drug-resistant cancers
6. Combination therapy beneficial for head and neck skin carcinomas, UNC study shows
7. Phase II study shows new cancer drug combination significantly delays breast cancer progression
8. Shorter treatment with hepatitis C drug combination may be more beneficial, study shows
9. Combination therapy rids common infection from implanted medical devices
10. Metformin and exercise combination less effective for glucose control
11. Combination of existing safety checks could greatly reduce radiotherapy errors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2017)... ... July 25, 2017 , ... SureVest Insurance Group, ... to communities across North Carolina, is launching a charity event in conjunction with ... for the ongoing fight against bladder cancer. , The Bladder Cancer Advocacy Network ...
(Date:7/25/2017)... (PRWEB) , ... July 25, 2017 , ... ... Health, as medical director. Dr. Negrette has more than a decade of experience ... has worked closely with individuals fighting addictions, eating disorders, psychotic and manic conditions, ...
(Date:7/24/2017)... ... , ... Engineers at the University of Maryland have invented an entirely new ... energy that the body uses. , In ordinary batteries the electrical energy, or ... of the battery is generated by moving positive ions from one end to the ...
(Date:7/24/2017)... ... 2017 , ... Cosmetic Town, an online plastic surgery information community, announces a ... a daily basis. , The new video series will feature board-certified doctors explaining ... practices. , When asked about the new video series, the senior editor of ...
(Date:7/24/2017)... ... July 24, 2017 , ... ... scholarship awards to be awarded annually to and divided between two full-time university ... bringing awareness to Amazonian plant medicine. To apply for the scholarship, students are ...
Breaking Medicine News(10 mins):
(Date:7/15/2017)... Enterin Inc., a Philadelphia -based ... today announced the completion of a $12.7 million Series A ... as well as the participation of existing investors. ... the support of New Ventures III and our current investors, ... the potential of our platform technology to transform the course ...
(Date:7/14/2017)... 13, 2017 It should come as no surprise ... is in the midst of a crippling opioid epidemic. According ... the number of overdose deaths from opiate-based medications has quadrupled, ... a million dead from 2001 to 2015". During this time, ... has similarly quadrupled, drawing a compelling link between prescription and ...
(Date:7/13/2017)... -- RK Logistics Group, Inc. was awarded California ... Fremont, CA headquarters facility where it provides ... San Jose for hi-tech, pharmaceutical and biomedical ... with its Fremont Innovation District, is excited to strategically partner ... to the hundreds of biotech, pharma and biomed companies throughout ...
Breaking Medicine Technology: