Navigation Links
Combination therapy provides similar clinical benefit as single drug treatment in MS
Date:3/11/2013

People with multiple sclerosis (MS) who were treated with combination therapy did not see significant clinical benefit over those treated with single drug therapy, but combination therapy did reduce the development of new lesions, according to an international research team led by The Mount Sinai Medical Center. The findings, part of the largest-ever MS trial sponsored by the National Institutes of Health, are published in the March 11 issue of Annals of Neurology.

In the Phase III CombiRx trial, researchers led by Fred Lublin, MD, of The Mount Sinai Medical Center, sought to determine if Glatiramer Acetate (GA) and Interferon Beta-1a (IFN), the two most commonly-prescribed drugs for relapsing-remitting MS (RRMS), were more effective in combination than as monotherapies. The results showed that while combination therapy was no better than monotherapy, patients who took combination therapy had a reduction in new lesions on MRI scan.

"This is the first NIH-sponsored, multi-center, comparative trial evaluating the benefits of both combination therapy and monotherapy in MS," said lead author Fred Lublin, MD, Director of the Corinne Goldsmith Dickinson Center for Multiple Sclerosis at The Mount Sinai Medical Center. "The study is the first to show that a combination trial is feasible in MS, to compare a combination to established monotherapy, and to provide comparative efficacy data for two commonly-prescribed drugs."

The research team enrolled 1,008 participants from 68 sites to receive IFN plus GA (499), IFN alone (250), or GA alone (259), with 30g IFN administered intramuscularly weekly and/or 20 mg of GA injected daily. The groups were followed for three years to assess if the combination therapy reduced MS relapse rates.

While combining IFN and GA was safe and effective, patients taking this regimen did not see clinical benefit greater than those taking a single agent. There was no substantial improvement in neurologi
'/>"/>

Contact: Christie Corbett
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Comparing combination therapies for advanced head and neck cancer shows no improvement
2. New drug combination could prevent head and neck cancer in high-risk patients
3. Mayo Clinic: 2-drug combination may slow deadly thyroid cancer
4. People with HIV hospitalized less often since combination antiretroviral drug therapy introduced
5. Combination of imaging exams improves Alzheimers diagnosis
6. Drug combination acts against aggressive chronic lymphocytic leukemia
7. Scientists test 5,000 combinations of 100 existing cancer drugs to find more effective treatments
8. Combination treatment may improve survival of breast cancer patients with brain metastases
9. Drug combination against NRAS-mutant melanoma discovered
10. Combination peptide therapies might offer more effective, less toxic cancer treatment
11. DNDi and Cipla to develop 4-in-1 pediatric antiretroviral drug combination
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... Cubit Labs is pleased to announce YOUnify for ... , The popular cross platform contact sharing app first ... gleaning a solid 5 star rating in BlackBerry World ... been so easy and I highly recommend this for ... CrackBerry.com, View full App review here: http://crackberry.com/younify-blackberry-10? ...
(Date:9/23/2014)... Today Bibliomotion celebrates the ... Life to Work: A Guide for Leaders and ... book, Brower proves that organizations accomplish the best results ... informal cultural practices that help employees integrate and navigate ... that the investment will pay significant dividends in employee ...
(Date:9/23/2014)... 23, 2014 "Bee Towers” was featured on ... and features the latest technology gadgets and services available to ... conducted the tech review and shared with viewers ... fatigue. , Tablet sales rates in the United States continue ... Americans now own a tablet. , For consumers who ...
(Date:9/23/2014)... (PRWEB) September 23, 2014 According to ... Tough Mudder team just completed the Pittsburg 2014 ... course event that helps fund the wounded warrior project. ... Mudder team member, the ”Tough Mudder is an endurance ... course. Designed and created by British Special Forces to ...
(Date:9/23/2014)... PA (PRWEB) September 23, 2014 Rinovum ... home-use conception assistance device on the market cleared by ... in stores and online at http://www.storkotc.com . , ... dream of having a baby is delayed by infertility1 ... first step to optimize their chances to conceive. ...
Breaking Medicine News(10 mins):Health News:YOUnify for Android is Now Available in the Google Play Store 2Health News:Tracy Brower ‘Brings Work to Life’ in Her New Book, Published By Bibliomotion 2Health News:Tracy Brower ‘Brings Work to Life’ in Her New Book, Published By Bibliomotion 3Health News:Tracy Brower ‘Brings Work to Life’ in Her New Book, Published By Bibliomotion 4Health News:Tracy Brower ‘Brings Work to Life’ in Her New Book, Published By Bibliomotion 5Health News:“Bee Towers”, a Floor Standing Tablet Holder by XAR Motion, was Featured on NewsWatch, a National Television Show, This Month 2Health News:First-Ever Conception Assistance Device FDA-Cleared for Home Use Launches U.S. OTC Sales -- The Stork® OTC Delivers Hope to Millions Struggling to Conceive A Child 2Health News:First-Ever Conception Assistance Device FDA-Cleared for Home Use Launches U.S. OTC Sales -- The Stork® OTC Delivers Hope to Millions Struggling to Conceive A Child 3Health News:First-Ever Conception Assistance Device FDA-Cleared for Home Use Launches U.S. OTC Sales -- The Stork® OTC Delivers Hope to Millions Struggling to Conceive A Child 4
... International Retail Expansion, With Near Term Focus on Top ... ExtensionIRVINE, Calif., Jan. 21 University Medical ... and efficacy-based skin and beauty care products sold at ... U.S., announced today that it has appointed Tom Roche ...
... following statement can be attributed to Michael J. ... consistently said two things: We are not inherently ... we have urged public policy makers to think ... without conditions, because without conditions the merger would ...
... 21 Omnicell, Inc. (Nasdaq: OMCL ), a leading provider ... 29 to discuss the Company,s fourth quarter 2008 financial results. , ... webcast, ... Who: Randall Lipps, chairman, president and chief executive officer, ...
... (Nasdaq: IDXX ), has scheduled the release of ... January 30, at approximately 7:00 a.m. (eastern). The Company will ... on that day. Individuals can access a live Webcast of ... site, www.idexx.com . An archived edition of the call ...
... Carolina researchers say it could detect virus that can ... -- A new urine test that can detect a ... to better diagnosis and treatment of patients with polyomavirus ... patients. , Polyomaviruses are harmless to healthy adults ...
... -- Schizophrenia may blur the boundary between internal and ... involved in self-reflection, and thus causing an exaggerated focus ... study has found. , The traditional view of ... that characterize the disease are caused by disconnections among ...
Cached Medicine News:Health News:University Medical Pharmaceuticals Appoints Tom Roche as Senior Vice President, Global Sales and Marketing 2Health News:University Medical Pharmaceuticals Appoints Tom Roche as Senior Vice President, Global Sales and Marketing 3Health News:Capital Blue Cross Issues Statement on Withdrawal of Merger 2Health News:Omnicell to Release Fourth Quarter 2008 Earnings Results on January 29 2Health News:New Test May Help Kidney Transplant Patients 2Health News:Altered brain activity in schizophrenia may cause exaggerated focus on self 2Health News:Altered brain activity in schizophrenia may cause exaggerated focus on self 3
(Date:9/23/2014)... 2014 Avillion LLP, a ... of Jarrod Longcor as Chief Business ... for structuring, negotiating and executing successful strategic alliances, ... providing management and strategic leadership to the organisation. ... team. Mr Longcor brings to Avillion ...
(Date:9/22/2014)... BARCELONA , España, September 23, 2014 ... nube permite que los patrocinadores de ensayos clínicos satisfagan ... a la accesibilidad y exhaustividad de los expedientes permanentes ... La mayor encuesta sobre TMF en el ... un aumento en el número de patrocinadores de ensayos ...
(Date:9/22/2014)... Spanien, September 23, 2014 ... sich Fernzugriffe auf eTMF im Jahr 2015 ... den Sponsoren von klinischen Versuchsreihen, die zunehmenden ... Vollständigkeit von Stammdateien mit Informationen über ihre ... erfüllen     Die bisher größte ...
Breaking Medicine Technology:Avillion Appoints Jarrod Longcor as Chief Business Officer 2El acceso remoto al eTMF se duplicará en 2015, revela una encuesta general del sector 2El acceso remoto al eTMF se duplicará en 2015, revela una encuesta general del sector 3El acceso remoto al eTMF se duplicará en 2015, revela una encuesta general del sector 4El acceso remoto al eTMF se duplicará en 2015, revela una encuesta general del sector 5Branchenweite Umfrage zeigt, dass sich Fernzugriffe auf eTMF im Jahr 2015 verdoppeln werden 2Branchenweite Umfrage zeigt, dass sich Fernzugriffe auf eTMF im Jahr 2015 verdoppeln werden 3Branchenweite Umfrage zeigt, dass sich Fernzugriffe auf eTMF im Jahr 2015 verdoppeln werden 4Branchenweite Umfrage zeigt, dass sich Fernzugriffe auf eTMF im Jahr 2015 verdoppeln werden 5
... MELVILLE, N.Y., Nov. 28, 2011  Henry Schein, Inc. ... of health care products and services to office-based ... Complete™ program, a new integrated comprehensive solution that ... for the successful implementation of dental sleep medicine ...
... Medical Incorporated (OTCBB: ONCS), a biotechnology company developing ... cancer and other solid tumor cancers, today announced ... presenting at the 15th Annual Biotech and Specialty ... (Logo: http://photos.prnewswire.com/prnh/20110314/MM64943LOGO ) ...
Cached Medicine Technology:Patients Can Now Visit Their Dentist for Treatment and Monitoring of Sleep Apnea 2Patients Can Now Visit Their Dentist for Treatment and Monitoring of Sleep Apnea 3Patients Can Now Visit Their Dentist for Treatment and Monitoring of Sleep Apnea 4Patients Can Now Visit Their Dentist for Treatment and Monitoring of Sleep Apnea 5OncoSec to Present at 15th Annual Biotech and Specialty Pharmaceuticals Conference 2
... The UrinQuick Urine Chemistry Analyzer is ... analysis of urine test strips. The UrinQuick ... for QuickVue UrinChek 10+ SG and QuickVue ... analyzes the urine test strips by reflectance ...
... a qualitative assay for rapid detection of Strep ... Strep A test excels at detection of Strep ... colonization samples. This CLIA Waived test uses a ... Strep A leaves little chance for misdiagnosis, minimizing ...
The NOW Flu A test is the most frequently adopted rapid flu test on the market today. Testing could not be easier and the results are available in 15 minutes. Now you can focus on the results and tre...
...
Medicine Products: