Navigation Links
Combination targets: some drugs may work best when they work together
Date:10/24/2007

crease the cytotoxicity of the TRAIL-receptor antibodies, as if conventional chemotherapy can lower the cell death threshold of cancer cells enough for the TRAIL pathway to be more effective.

Humphreys and his colleagues experimented with combinations of cisplatin, 5-fluorouracil and gemcitabine given with or prior to treatment with the human TRAIL-receptor antibodies in cholangiocarcinoma cell cultures. Their findings indicated that treating CCA cell lines with a single chemotherapeutic agent 24 hours before administering either antibody increased cytotoxicity, killing nearly 90 percent of cells. According to Humphreys, mouse xenograft studies showed that co- or pre-treatment of a CCA xenograft tumor with cisplatin or gemcitabine before administering mapatumumab significantly inhibited tumor growth and displayed tumor regression over the 40-day period of the trials.

Since human biliary cancer remains a relatively rare cancer, with an annual incidence of about one or two cases per 100,000 people in the Western world, there has been little research toward a specific treatment for this disease, the researchers contend. This pre-clinical data supports potential clinical trials of a TRAIL-R mAb and chemotherapy combination in CCA, Humphreys says.


'/>"/>

Contact: Greg Lester
greg.lester@aacr.org
267-646-0554
American Association for Cancer Research
Source:Eurekalert

Page: 1 2 3 4 5 6 7

Related medicine news :

1. Consensus on "Combination Therapy" for Breast Cancer
2. Smoking and Breast Cancer - A Deadly Combination
3. The bad combination
4. Drug Combinations May Boost Stroke Risk
5. Combination therapy to treat breast cancer
6. Combination regime may work against prostate cancer
7. New Drug Combination Found To Improve Memory in Alzheimer’s Patient
8. A Combination Of Drugs Effective In The Treatment Of Hormone-Refractory Prostate Cancer
9. Combination Therapy Effective In Improving Lung Cancer Survival
10. Combination Therapy Found To Improves Stroke Recovery
11. Combination Therapy Found To Be More Effective In Treating Brain Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... 2014 The holidays are here, and with ... Many may be thinking about how to enjoy these events ... weeks. Health Republic Insurance of New York has compiled some ... to provide some smart ideas to enjoy the holiday festivities ... arriving at a holiday gathering over-hungry , Have a light ...
(Date:12/22/2014)... New York, NY (PRWEB) December 22, 2014 ... out 2014 stronger than ever, having invested more ... post-9/11 injured service members, veterans and their families. ... today for nearly a dozen nonprofits, helping with: ... peer-support; nursing scholarships; and life-coaches for severely injured ...
(Date:12/22/2014)... December 22, 2014 In recognition of ... sales to Hero Reward, a local organization that provides ... , Located on a couple hundred acres ... Program offers lodging, world class fishing, hunting, hiking, horseback ... was founded several years ago to support U.S. Service ...
(Date:12/22/2014)... (PRWEB) December 22, 2014 TheHardwareCity.com now ... glove with many useful features. Customers of the large ... have the new gloves delivered to their home or ... and hand tools that incorporate heavy duty magnets, which ... Glove allows workers to store metal parts on the ...
(Date:12/22/2014)... December 21, 2014 A substantial ... chest computed tomography (CT) to evaluate abnormal findings ... including cancer, according to a new study published ... said the findings show that radiologist recommendations for ... contributions to patient care. , RAIs, which have ...
Breaking Medicine News(10 mins):Health News:Health Republic Insurance of New York Offers Five Simple Tips to Eat Healthy During the Holidays 2Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 2Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 3Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 4Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 5Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 6Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 7Health News:Discount Labels Donates Portion of November Sales to Hero Reward Program 2Health News:MagnoGrip Pro Utility Magnetic Gloves on Sale at TheHardwareCity.com 2Health News:RSNA: Radiologist Recommendations for Chest CT Have High Clinical Yield 2Health News:RSNA: Radiologist Recommendations for Chest CT Have High Clinical Yield 3
... Russian President Vladimir Putin to Adopt a National ... Plan ... Cancer, a cancer,patient advocacy group in Russia, today launched an effort ... in Russia to innovative and effective treatments, including,diagnostic procedures and the ...
... Public Services, Inc.,a subsidiary of SAP AG (NYSE: ... vice,president of its U.S. healthcare practice. The appointment ... initiatives to improve the quality and delivery of,healthcare ... for growing,SAP,s business in the U.S. healthcare sector ...
... Joyce Erony Joins Board of Directors -, PALO ... device company that is developing a new category of ... that,it has raised $21 million in a Series C ... also announced that Joyce Erony,managing director of Signet Healthcare ...
... FRANKLIN LAKES, N.J., Feb. 4 Medco Health,Solutions, Inc. ... and,full-year 2007 financial results in a press release before ... the release, management will hold a conference call to ... a.m. ET., To access the live conference call ...
... is the First and Only Inhaled Corticosteroid approved for ... Once-Daily dosing in Children as Young as Age 4, ... today announced that the U.S. Food and Drug,Administration (FDA) has ... for the maintenance treatment of,asthma as a preventive therapy in ...
... Cherries, May Help Protect Your Heart, LANSING, Mich., ... universal mantras for promoting heart-health during February,American Heart Month. ... eating red to protect our hearts. Americans are encouraged ... the first-ever National,Eat Red Week, Feb. 4-10., Why ...
Cached Medicine News:Health News:Movement Against Cancer, a Cancer Patient Advocacy Group in Russia, Launches an Effort to Inform Russian Authorities and the Public About Inadequate Access of Innovative and Effective Cancer Treatments for Cancer Patients in Russia 2Health News:SAP Names David Corbett as Vice President of U.S. Healthcare Practice 2Health News:SAP Names David Corbett as Vice President of U.S. Healthcare Practice 3Health News:SAP Names David Corbett as Vice President of U.S. Healthcare Practice 4Health News:SAP Names David Corbett as Vice President of U.S. Healthcare Practice 5Health News:PEAK Surgical, Inc. Closes $21 Million Series C Financing 2Health News:Medco Announces Date for Fourth-Quarter and Full-Year 2007 Financial Results 2Health News:FDA Approves ASMANEX (R) TWISTHALER(R) (Mometasone Furoate Inhalation Powder) for the Once Daily Maintenance Treatment of Asthma in Children Ages 4-11 2Health News:FDA Approves ASMANEX (R) TWISTHALER(R) (Mometasone Furoate Inhalation Powder) for the Once Daily Maintenance Treatment of Asthma in Children Ages 4-11 3Health News:FDA Approves ASMANEX (R) TWISTHALER(R) (Mometasone Furoate Inhalation Powder) for the Once Daily Maintenance Treatment of Asthma in Children Ages 4-11 4Health News:FDA Approves ASMANEX (R) TWISTHALER(R) (Mometasone Furoate Inhalation Powder) for the Once Daily Maintenance Treatment of Asthma in Children Ages 4-11 5Health News:FDA Approves ASMANEX (R) TWISTHALER(R) (Mometasone Furoate Inhalation Powder) for the Once Daily Maintenance Treatment of Asthma in Children Ages 4-11 6Health News:Celebrate American Heart Month by Eating Red 2Health News:Celebrate American Heart Month by Eating Red 3
(Date:12/19/2014)... Dec. 18, 2014 Capnia, Inc. (NASDAQ: ... of medical diagnostics based on its proprietary Sensalyze™ ... today announced financial results for the third quarter ... "Following the completion of our initial public ... maximize the recently initiated CoSense® commercial launch," said ...
(Date:12/19/2014)... Baptist Health Lexington is the first facility in ... with Electrophysiology Services (EPS) Accreditation status from the Society of ... most common cardiac arrhythmia and has become recognized as a ... and possible death. More than 5 million patients in ... the numbers are rapidly increasing as the population ages. ...
(Date:12/19/2014)... Dec. 18, 2014   Aratana Therapeutics, Inc ... company focused on the licensing, development and commercialization ... positive results from its pivotal field study of ... pain in dogs with osteoarthritis.  In the study, ... scores that were statistically significant compared to placebo ...
Breaking Medicine Technology:Capnia Reports Third Quarter 2014 Financial Results 2Capnia Reports Third Quarter 2014 Financial Results 3Capnia Reports Third Quarter 2014 Financial Results 4Capnia Reports Third Quarter 2014 Financial Results 5Capnia Reports Third Quarter 2014 Financial Results 6Capnia Reports Third Quarter 2014 Financial Results 7Capnia Reports Third Quarter 2014 Financial Results 8Baptist Health Lexington First in the Nation to Receive Atrial Fibrillation with EPS Accreditation 2Baptist Health Lexington First in the Nation to Receive Atrial Fibrillation with EPS Accreditation 3Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 2Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 3Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 4Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 5
The DEI 750 MD from Optronics is a surgical 3 CCD color microscope camera with a 10 meter head cable. Easily mounts on your microscopes C-mount adapter and is the best choice for your surgical imagin...
... The Optronics QuantiFIRE represents the ... in advanced scientific grade CCD imaging ... Thermoelectrically Cooled Monochrome CCD camera developed ... low-light, darkfield, fluoresence or NIR imaging ...
The Optronics MacroFIRE represents the latest innovation from the world leader in advanced scientific grade CCD imaging for microscopy. MacroFIRE is a versatile CCD camera developed exclusively for c...
... is an Ancient Chinese Method of enhancing health ... fosters health and healing by promoting a smooth ... that the body can heal itself. However, it ... Soleil experts have spent years mastering Qigong and ...
Medicine Products: