Navigation Links
Combination targets: some drugs may work best when they work together
Date:10/24/2007

crease the cytotoxicity of the TRAIL-receptor antibodies, as if conventional chemotherapy can lower the cell death threshold of cancer cells enough for the TRAIL pathway to be more effective.

Humphreys and his colleagues experimented with combinations of cisplatin, 5-fluorouracil and gemcitabine given with or prior to treatment with the human TRAIL-receptor antibodies in cholangiocarcinoma cell cultures. Their findings indicated that treating CCA cell lines with a single chemotherapeutic agent 24 hours before administering either antibody increased cytotoxicity, killing nearly 90 percent of cells. According to Humphreys, mouse xenograft studies showed that co- or pre-treatment of a CCA xenograft tumor with cisplatin or gemcitabine before administering mapatumumab significantly inhibited tumor growth and displayed tumor regression over the 40-day period of the trials.

Since human biliary cancer remains a relatively rare cancer, with an annual incidence of about one or two cases per 100,000 people in the Western world, there has been little research toward a specific treatment for this disease, the researchers contend. This pre-clinical data supports potential clinical trials of a TRAIL-R mAb and chemotherapy combination in CCA, Humphreys says.


'/>"/>

Contact: Greg Lester
greg.lester@aacr.org
267-646-0554
American Association for Cancer Research
Source:Eurekalert

Page: 1 2 3 4 5 6 7

Related medicine news :

1. Consensus on "Combination Therapy" for Breast Cancer
2. Smoking and Breast Cancer - A Deadly Combination
3. The bad combination
4. Drug Combinations May Boost Stroke Risk
5. Combination therapy to treat breast cancer
6. Combination regime may work against prostate cancer
7. New Drug Combination Found To Improve Memory in Alzheimer’s Patient
8. A Combination Of Drugs Effective In The Treatment Of Hormone-Refractory Prostate Cancer
9. Combination Therapy Effective In Improving Lung Cancer Survival
10. Combination Therapy Found To Improves Stroke Recovery
11. Combination Therapy Found To Be More Effective In Treating Brain Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... TUESDAY, Oct. 21, 2014 (HealthDay News) -- Measures taken ... plantation in Ebola-ravaged Liberia may have limited the spread ... researchers report. The Firestone Natural Rubber Co. provides ... and residents of nearby densely populated communities. Between ... and suspected Ebola cases among those 80,000 people. That ...
(Date:10/20/2014)... Texas (PRWEB) October 20, 2014 The ... the must-have source of thousands of facts, figures and ... countries and 68 medical sector forecast categories the ... with global, regional and national views on the worldwide ... outlook. , The report gives you data for 2010-2019, ...
(Date:10/20/2014)... 2014 The Advocator Group, LLC ... the American Foundation for Suicide Prevention’s (AFSP) Out of ... a not-for-profit organization that hosts hundreds of community walks ... events are used to help understand and prevent suicide ... relationships as well. , The Advocator Group shares ...
(Date:10/20/2014)... T.E.N., a technology and information ... that William H. Murray, renowned author and industry ... Leadership Award winner. Presented annually, the ISE® Luminary ... leader and industry practitioner for his or her ... information security industry. , Formerly with IBM, Murray ...
(Date:10/20/2014)... Angeles, CA (PRWEB) October 20, 2014 ... fitness expertise, nutritional coaching, corporate wellness programming, authorship, international ... CPT, is excited to announce the release of the ... , After many years of coaching thousands of individuals ... nutrition tracking app that does not require calorie counting ...
Breaking Medicine News(10 mins):Health News:Tire Company Sets Standard for Ebola Care in Liberia: CDC 2Health News:Worldwide Medical Market Forecasts to 2019 a New Research Report Added to ReportsnReports.com 2Health News:Worldwide Medical Market Forecasts to 2019 a New Research Report Added to ReportsnReports.com 3Health News:Worldwide Medical Market Forecasts to 2019 a New Research Report Added to ReportsnReports.com 4Health News:The Advocator Group, LLC is Proud to Participate in an Out of the Darkness Community Walk, October 25th, to Increase Suicide Awareness 2Health News:The Advocator Group, LLC is Proud to Participate in an Out of the Darkness Community Walk, October 25th, to Increase Suicide Awareness 3Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 2Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 3Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 4Health News:JZ Fitness Nutrition App Launches on iTunes 2Health News:JZ Fitness Nutrition App Launches on iTunes 3
... Researchers at the University of Pennsylvania School of ... associated with familial Alzheimer,s disease disrupt the flow ... called PS1 and PS2 (presenilin 1 and 2), ... intracellular cell compartment. , "The ,calcium dysregulation, hypothesis ...
... Without immediate action to develop an integrated, comprehensive, national health ... status as the global health care leader, states a new ... www.aahcdc.org ). The report was funded in part ... Out of Time: The State of the Nation,s Health Workforce ...
... cancer patients develop resistance to chemotherapy drugs, sometimes abruptly, ... be working well to reduce tumors or hold them ... the result when this occurs is all too familiar: ... cancers become resistant. , A team of researchers at ...
... Baxa Corporation, a,Denver-based manufacturer of medical devices and ... the release,of a newly designed Web site for ... The online forum, known as eBUG for,electronic Baxa ... along,with creating a virtual ,community, for sharing pharmacy ...
... SIOUX FALLS, S.D., July 18 William S.,Harris, ... letter,dated July 16:, Eating fish, especially oily ... heart disease prevention. Fish is low in total ... minerals, and contains,long-chain omega-3 fatty acids (EPA and ...
... YORK, July 18 Standing Tall announced today ... Board of Directors., "Standing Tall has created ... the most severely disabled children in New York ... gain mobility and independence,by actively using their bodies ...
Cached Medicine News:Health News:Calcium may be the key to understanding Alzheimer's disease 2Health News:Calcium may be the key to understanding Alzheimer's disease 3Health News:New report warns current policies will not avert health workforce crisis 2Health News:CSHL scientists correlate enzyme expression levels with chemotherapy drug response 2Health News:CSHL scientists correlate enzyme expression levels with chemotherapy drug response 3Health News:CSHL scientists correlate enzyme expression levels with chemotherapy drug response 4Health News:Baxa Corporation Launches New Electronic Users' Group Web Site 2Health News:An Open Letter Regarding Recent Reports That Low-Fat Fish Like Tilapia Are Unhealthy (July 16, 2008) 2Health News:An Open Letter Regarding Recent Reports That Low-Fat Fish Like Tilapia Are Unhealthy (July 16, 2008) 3Health News:Bernadette Peters Joins Board of Directors of Standing Tall, Innovative Program for Multiply Disabled Children 2
(Date:10/22/2014)... 2014 Moms are ready to live the ... and their kids, according to the results of the ... Go Mobile for Moms, the latest installment in BabyCenter,s ... 1 pregnancy and parenting web and mobile destination worldwide, ... moms surveyed say they can,t think of a reason ...
(Date:10/22/2014)... , Oct. 22, 2014 AVACEN Medical ... device received 510 (k) OTC clearance by the U.S. ... 100 to be marketed over the Internet for: ... muscle spasms; and minor strains and sprains . ... The AVACEN 100 (MSRP $2495) is a sophisticated medical ...
(Date:10/22/2014)... , Oct. 22, 2014  CryoLife, Inc. (NYSE: ... tissue processing company focused on cardiac and vascular surgery, ... President and Chief Executive Officer, has been elected to ... Steven G. Anderson , Executive Chairman ... has proven to be an excellent leader who is ...
Breaking Medicine Technology:BabyCenter Finds Mom Ready to Live the "Measured Life" in its U.S. Mobile Mom 2014 Report: Health & Fitness Go Mobile for Moms 2BabyCenter Finds Mom Ready to Live the "Measured Life" in its U.S. Mobile Mom 2014 Report: Health & Fitness Go Mobile for Moms 3BabyCenter Finds Mom Ready to Live the "Measured Life" in its U.S. Mobile Mom 2014 Report: Health & Fitness Go Mobile for Moms 4AVACEN Medical Announces FDA Clearance of First Medical Device with Internal Game Mode 2Pat Mackin Joins CryoLife Board of Directors 2Pat Mackin Joins CryoLife Board of Directors 3
... , , TEANECK, N.J. , Jan. 26 ... who was sued in 2008 for alleged misappropriation of her employer,s assets, has ... her in the Superior Court of New Jersey . Yueh,s trial took ... of the Superior Court of New Jersey stated in her ruling ...
... , PLEASANTON, Calif. , Jan. 25 ... in device-based mechanical circulatory support (MCS) therapies to save, support ... an innovative catheter pump technology that it plans to use ... flow pump that can be delivered percutaneously in the cardiac ...
Cached Medicine Technology:Pharma CI Conference Amy Yueh Pays $52,000 to Apaporis LLC to Satisfy Judgment Against Her In Superior Court Of New Jersey Case 2Pharma CI Conference Amy Yueh Pays $52,000 to Apaporis LLC to Satisfy Judgment Against Her In Superior Court Of New Jersey Case 3Thoratec Announces Acquisition of Innovative Catheter-Based Heart Pump Technology 2Thoratec Announces Acquisition of Innovative Catheter-Based Heart Pump Technology 3Thoratec Announces Acquisition of Innovative Catheter-Based Heart Pump Technology 4
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: