Navigation Links
Combination targets: some drugs may work best when they work together
Date:10/24/2007

ning it with ABT-737, a small molecule drug that primes tumor cells to undergo apoptosis, or programmed cell death.

About ten percent of tumors from lung cancer patients harbor mutations in the kinase domain of the epidermal growth factor receptor (EGFR) gene, and these mutations are associated with increased sensitivity to EGFR TKIs. said Yixuan Gong, Ph.D., a post-doctoral researcher at Memorial Sloan-Kettering. EGFR TKIs, while certainly beneficial, unfortunately, do not cure patients whose tumors have these mutations, and resistance develops after long time use. Were attempting to enhance the effectiveness of EGFR TKIs by combining TKI therapy with ABT-737, a BCL-2 inhibitor.

According to Gong, mutated EGFRs produce growth signals that drive uncontrolled lung tumor cell division. Inhibition of mutated EGFR is a very effective treatment for these types of lung cancers, she says.

Gong and her colleagues at Memorial Sloan-Kettering demonstrated how lung cancer cell lines with EGFR mutations undergo apoptosis when exposed to erlotinib. In particular, they found that such cells die by a mechanism called the intrinsic apoptotic pathway. Erlotinib, the researchers say, induces dramatic changes in the pro-apoptotic protein, BIM, and this protein is required for erlotinib-triggered cell death.

The improved understanding of how EGFR mutant cells actually respond to EGFR TKIs will help us to identify strategies to enhance tumor cell death and will also help us to look for possible reasons why tumor cells persist despite treatment, Gong said.

In studies of EGFR TKI-sensitive cancer cells, the researchers found that ABT-737 significantly enhanced erlotinib-induced cell death. It is proof of principle that you can enhance tumor response to EGFR TKIs by priming tumor cells to a more deathprone state with small molecules that manipulate the intrinsic apoptotic pathway, Gong said. We hope to design clinical trials based on this st
'/>"/>

Contact: Greg Lester
greg.lester@aacr.org
267-646-0554
American Association for Cancer Research
Source:Eurekalert

Page: 1 2 3 4 5 6 7

Related medicine news :

1. Consensus on "Combination Therapy" for Breast Cancer
2. Smoking and Breast Cancer - A Deadly Combination
3. The bad combination
4. Drug Combinations May Boost Stroke Risk
5. Combination therapy to treat breast cancer
6. Combination regime may work against prostate cancer
7. New Drug Combination Found To Improve Memory in Alzheimer’s Patient
8. A Combination Of Drugs Effective In The Treatment Of Hormone-Refractory Prostate Cancer
9. Combination Therapy Effective In Improving Lung Cancer Survival
10. Combination Therapy Found To Improves Stroke Recovery
11. Combination Therapy Found To Be More Effective In Treating Brain Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/22/2014)... 2014 Hastings and Hastings, a discount ... announces providing clients with the option of leaving an ... a flexible, intuitive and easy to navigate website that ... to Google + allows clients to research the Hastings ... more informed decision when retaining an attorney. Those who ...
(Date:11/22/2014)... Petersburg, FL (PRWEB) November 22, 2014 ... Kitchen Innovations are pleased to announce that Ashley ... the Thanksgiving #PayItForward contest. , Ms. Lombardo entered ... from Kitchen Innovations. She wrote of how her friend ... young daughters as a single mom. Despite medical bills ...
(Date:11/22/2014)... November 22, 2014 Sandbridge Capital, ... investments in the consumer brand sector, acquired a ... will be used to help fund BackJoy’s global ... rollout, particularly its proprietary apparel and footwear lines. ... BackJoy’s Board of Directors. , BackJoy is a ...
(Date:11/22/2014)... Viejo, California (PRWEB) November 22, 2014 Developers ... announced a new plugin entitled FCPX 3D Model bringing the ... “FCPX 3D Model allows users to add obj files to ... Pixel Film Studios. “Blurring the line between professional and armature, ... Model from Pixel Film Studios allows Final Cut Pro X ...
(Date:11/22/2014)... Wright & Schulte LLC reports that six ... scheduled between October 2016 and April 2017 in the ... Judge Matthew F. Kennelly, who is overseeing the consolidated ... November 6, 2014 that outlined the trial schedule as ... other activities in preparation for the bellwether jury trials. ...
Breaking Medicine News(10 mins):Health News:Hastings and Hastings Announces Providing Clients with the Option of Leaving an Online Review Using Google + 2Health News:Hastings and Hastings Announces Providing Clients with the Option of Leaving an Online Review Using Google + 3Health News:Forbes Living TV Announces Winner of Thanksgiving #PayItForward Contest 2Health News:Sandbridge Capital Acquires a Minority Stake in BackJoy 2Health News:Sandbridge Capital Acquires a Minority Stake in BackJoy 3Health News:Pixel Film Studios released FCPX 3D Model plugin Exclusively for Final Cut Pro X 2Health News:First Bellwether Trials Scheduled In AndroGel Side-Effects Lawsuits Reports Wright & Schulte LLC 2Health News:First Bellwether Trials Scheduled In AndroGel Side-Effects Lawsuits Reports Wright & Schulte LLC 3Health News:First Bellwether Trials Scheduled In AndroGel Side-Effects Lawsuits Reports Wright & Schulte LLC 4
... TOWN, South Africa, May 11 ... feel the effects of the global economic slowdown. ... rising health costs and constrained healthcare resources.(Logo: ... are those whose economies are largely driven by ...
... Firm Recognizes Efforts in Patient Satisfaction , ... South ... Press Ganey Associates, Inc., is proud to recognize all of ... of care they provide., , , , ,“The doctors, nurses, and ...
... May 11 , - Health of the Nation has ... - Britain is Overwhelmed, Overworked and Overweight, - 1.9 ... The nation appears to be stuck in a downward ... time and,money by cutting back on exercise and healthy foods in the ...
... likely than men to feel the pinch of rising ... (52%) of working-age women reporting problems accessing needed care ... a new Commonwealth Fund study finds. Women who are ... percent of underinsured women have problems accessing care because ...
... The winners of today,s Susan G. Komen Pittsburgh Race ... Winners , Male: Pat McGuire, Greensburg, Pa., 15:35 ... Place Overall Winners , Male: Steven Strelick, 16:05 ... Overall Winners , Male: Charlie Ban, Pittsburgh, ...
... Increased strain on the system will increase misdiagnosis or late diagnosis of ... Gurfein Douglas LLP , ... New York, NY (PRWEB) May 10, 2009 ... will not only cause delays in breast, colon and cervical cancer screening ...
Cached Medicine News:Health News:Not All Gloomy for African Healthcare Markets: Frost & Sullivan Finds Potential Despite the Recession 2Health News:Not All Gloomy for African Healthcare Markets: Frost & Sullivan Finds Potential Despite the Recession 3Health News:Press Ganey Supports National Hospital Week 2Health News:Press Ganey Supports National Hospital Week 3Health News:Stressed and Sedentary Lifestyles Increase as Recession Appears to Take its Toll on Britain's Health 2Health News:Stressed and Sedentary Lifestyles Increase as Recession Appears to Take its Toll on Britain's Health 3Health News:Stressed and Sedentary Lifestyles Increase as Recession Appears to Take its Toll on Britain's Health 4Health News:7 of 10 women are uninsured or underinsured, or have medical bill, debt, access problems 2Health News:7 of 10 women are uninsured or underinsured, or have medical bill, debt, access problems 3Health News:17th Annual Komen Pittsburgh Race for the Cure(R) 5K Winners Announced 2Health News:Budget Cuts for Free Cancer Screening Clinics in New York Could Put Patients' Lives at Risk, Says New York Medical Malpractice Lawyer 2Health News:Budget Cuts for Free Cancer Screening Clinics in New York Could Put Patients' Lives at Risk, Says New York Medical Malpractice Lawyer 3Health News:Budget Cuts for Free Cancer Screening Clinics in New York Could Put Patients' Lives at Risk, Says New York Medical Malpractice Lawyer 4
(Date:11/22/2014)...  Sprout Pharmaceuticals today announced positive preliminary results from a ... flibanserin up to 200 mg at bedtime had no next-day ... 20 th Annual Fall Scientific Meeting of the Sexual ... Miami . The Phase 1 ... Letter and the Formal Dispute Resolution that was filed in ...
(Date:11/22/2014)... -- New data demonstrates that flibanserin, a novel, non-hormonal medicine ... sexual dysfunction, Hypoactive Sexual Desire Disorder (HSDD), does not ... women when taken at bedtime. The data was presented ... America,s (SMSNA) 20th Annual Fall Scientific Meeting ... SMSNA accepted this study as a late breaking abstract ...
(Date:11/22/2014)... JUNCTION, N.J. , Nov. 21, 2014 /PRNewswire/ ... company commercializing its European Union approved CytoSorb® cytokine ... worldwide, was awarded the Beacon of Light Award ... Awards Celebration.  Dr. Phillip ... "It is an honor to be recognized by ...
Breaking Medicine Technology:Sprout Pharmaceuticals Presents Phase 1 Clinical Trial Data Showing Treatment With Flibanserin Results In No Next-Day Driving Impairment 2Sprout Pharmaceuticals Presents Phase 1 Clinical Trial Data Showing Treatment With Flibanserin Results In No Next-Day Driving Impairment 3Study on Efficacy and Sedation-Related Safety of Flibanserin in Premenopausal Women Released Today at Sexual Medicine Society of North America Meeting 2Study on Efficacy and Sedation-Related Safety of Flibanserin in Premenopausal Women Released Today at Sexual Medicine Society of North America Meeting 3CytoSorbents Wins Beacon of Light Award 2CytoSorbents Wins Beacon of Light Award 3CytoSorbents Wins Beacon of Light Award 4
... DIEGO, Nov. 14, 2011 OncoSec Medical Incorporated (OTCBB: ... to treat solid tumor cancers, announced today that Punit ... 6th Annual Medical Device Investor Forum in Irvine, California. ... 6th Annual Medical Device Investor Forum Hyatt ...
... 14, 2011 /PRNewswire-Asia/ -- Winner Medical Group Inc. (Nasdaq: ... a leading, China-based exporter and retailer of high-quality medical ... reported preliminary unaudited consolidated financial results for the fourth ... fiscal fourth quarter results are unaudited and subject to ...
Cached Medicine Technology:OncoSec to Present at Medical Device Investor Forum 2Winner Medical Reports Selected Preliminary Unaudited Fourth Quarter Fiscal 2011 Results 2Winner Medical Reports Selected Preliminary Unaudited Fourth Quarter Fiscal 2011 Results 3Winner Medical Reports Selected Preliminary Unaudited Fourth Quarter Fiscal 2011 Results 4Winner Medical Reports Selected Preliminary Unaudited Fourth Quarter Fiscal 2011 Results 5Winner Medical Reports Selected Preliminary Unaudited Fourth Quarter Fiscal 2011 Results 6
... clinical and economic issues of cerclage wiring, ... to maximize tension control while minimizing invasion ... efficient instrumentation with a simple technique. , ... indicated for general orthopaedic trauma surgery involving: ...
OmniAccess&trade Hip Retractor System sets a new standard in hip exposure. It provides constant, absolute exposure of the acetabulum during total hip arthroplasty and revision procedures....
... aggressive innovations have become the accepted standard ... The AML Total Hip System was ... and effectively meet the needs for biological ... greater than 15 years of documented clinical ...
The Endotrac™ System includes an Obturator, Slotted Cannula, Synovial Elevator, Ligament Probe, Ligament Rasp, Blade Handle, two Retractors and sterilizable tray. The Endotrac&trade....
Medicine Products: