Navigation Links
Combination targets: some drugs may work best when they work together
Date:10/24/2007

nter. To understand the connections between these pathways we have taken a systems biology approach, one that may uncover new anti-cancer drug targets on different levels within connecting pathways.

As part of a multi-institutional research effort funded by the National Cancer Institutes Integrative Cancer Biology Program, Dr. Korn and his colleagues at UCSF, Lawrence Berkeley National Laboratories and The University of Texas M. D. Anderson Cancer Center are creating computer models informed by their systemic approach that will enable them to identify important proteins within the signaling networks. There so many different components involved, that modeling these pathways is as complicated as creating computer models that accurately predict the weather, Dr. Korn said.

The MEK protein is an enzyme involved in the well-studied RAS pathway, which plays a central role in promoting cell growth and multiplication. When not functioning properly, this pathway has been implicated in a number of cancers, Dr. Korn says, including breast cancer. When the researchers treated breast cancer cells with molecules designed to bind to and inhibit MEK, named U0126 and CII040, they observed that instead of dying, the cells simply froze at a single point in their life cycle.

While U0126 and CII040 prevented breast cancer cells from growing, they did not kill the cells implying that some breast cancer cells would survive treatment with MEK inhibitors, Dr. Korn says. In analyzing the performance of the MEK inhibitors, researchers noticed that a similar pathway, identified by the activity of an enzyme called PI3-kinase, had been activated. So, of course, we decided that we would try blocking the PI3-kinase pathway as well, assuming that simply blocking both pathways would work, Dr. Korn said.

However, combining the MEK inhibitors with a PI3-kinase inhibitor resulted in cells even more steadfastly resolved to stay alive.

That is when we dec
'/>"/>

Contact: Greg Lester
greg.lester@aacr.org
267-646-0554
American Association for Cancer Research
Source:Eurekalert

Page: 1 2 3 4 5 6 7

Related medicine news :

1. Consensus on "Combination Therapy" for Breast Cancer
2. Smoking and Breast Cancer - A Deadly Combination
3. The bad combination
4. Drug Combinations May Boost Stroke Risk
5. Combination therapy to treat breast cancer
6. Combination regime may work against prostate cancer
7. New Drug Combination Found To Improve Memory in Alzheimer’s Patient
8. A Combination Of Drugs Effective In The Treatment Of Hormone-Refractory Prostate Cancer
9. Combination Therapy Effective In Improving Lung Cancer Survival
10. Combination Therapy Found To Improves Stroke Recovery
11. Combination Therapy Found To Be More Effective In Treating Brain Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... iFitDress.com, one of the most famous dress suppliers in the ... collection. According to the company’s sales manager, all these ... 69% off) at present. Additionally, all the company’s old clients ... frequent caller of your site. I like your products very ... happy. All items are of good quality. I sincerely want ...
(Date:9/16/2014)... HealthDay Reporter TUESDAY, Sept. ... routinely spot human papillomavirus (HPV), which is linked to the ... study shows that testing urine for HPV has good accuracy ... HPV," said lead researcher Dr. Neha Pathak. She is a ... Mary University of London, England. The test could be ...
(Date:9/16/2014)... September 16, 2014 These new programs allow ... years to receive up to $10,000 in a 0% interest ... well as other state and federal programs, are listed on ... paid back until you sell or move out of the ... 0% interest loan. There are no monthly payments paid by ...
(Date:9/16/2014)... A new study found that fractional flow ... true coronary bifurcation lesions yields similar outcomes to ... trial is the first study to compare FFR-guided ... today at the 26th annual Transcatheter Cardiovascular Therapeutics ... Foundation (CRF), TCT is the world,s premier educational ...
(Date:9/16/2014)... September 16, 2014 Programs and policies ... hundreds of billions of dollars in savings for the ... the Commonwealth Fund. To help spur these types of ... to 10 collaborative groups from across the country to ... http://bit.ly/1wo4gsa ) - a handbook designed to assist groups ...
Breaking Medicine News(10 mins):Health News:iFitDress.com: One Shoulder Evening Gown Collection Unveiled Online 2Health News:Urine Test for HPV Works Well, Analysis Finds 2Health News:New Updated 2014 First Time Home Buyer Programs Available to Florida Residents 2Health News:New Updated 2014 First Time Home Buyer Programs Available to Florida Residents 3Health News:Results of DKCRUSH-VI trial reported at TCT 2014 2Health News:NQF Seeks Field Testing Groups for Population Health Guide 2Health News:NQF Seeks Field Testing Groups for Population Health Guide 3
... Cancer (CoC) of the American College of Surgeons has granted ... Cancer Center as a result of surveys performed in 2010. ... to receive this award, is one of a select group ... country. Established in 2004, the CoC Outstanding Achievement ...
... , TUESDAY, April 26 (HealthDay News) -- The increased use ... and rapid angioplasty, has led to a decrease in deaths, ... a Swedish coronary care registry on more than 61,000 patients ... known as STEMI between 1996 and 2007. During those ...
... Sheikh Zayed Institute for Pediatric Surgical Innovation at ,Children,s ... has shown early promise as an option for chronic, severe ... bacterial infections, particularly sepsis. The study, which appears ... , sheds new light on the role of a pain ...
... for publication in The Endocrine Society,s Journal of Clinical ... white children with vitamin D deficiency both had higher fat ... of fat just under their skin and white children were ... internal organs. Studies in adults and children have shown ...
... needs a national pharmacare program and federal leaders must ... ( Canadian Medical Association Journal ) http://www.cmaj.ca/cgi/doi/10.1503/cmaj.110643 ... and New Zealand, Canada lacks a national pharmacare program ... country. Currently, drugs that are covered in some provinces ...
... HealthDay Reporter , TUESDAY, April 26 (HealthDay News) -- ... the risk of developing Alzheimer,s disease, a new study ... to the house causes dementia, and other factors could ... the possible cost of isolation, said lead investigator Bryan ...
Cached Medicine News:Health News:Scott & White Glenda Vasicek Cancer Center receives national achievement award 2Health News:Evidence-Based Heart Attack Care Reduces Deaths: Study 2Health News:Evidence-Based Heart Attack Care Reduces Deaths: Study 3Health News:Study: Resiniferatoxin may increase sepsis-related mortality 2Health News:Vitamin D deficiency is associated with different types of obesity in black and white children 2Health News:Canadians should demand commitments for pharmacare program, says CMAJ 2Health News:Being 'Housebound' Linked to Alzheimer's in Elderly 2Health News:Being 'Housebound' Linked to Alzheimer's in Elderly 3
(Date:9/16/2014)... EVANSVILLE, Ind. , Sept. 16, 2014   ... builder of custom, automated assembly and test systems, recently ... for a leading medical device manufacturer. The Evana solution ... improve quality and ergonomics, as well as reduce labor. ... are automatically fed to Evana,s robotic assembly cell. The ...
(Date:9/16/2014)... 16, 2014   Vestagen Technical Textiles, Inc. ... at hospitals. The myComfort™ line of patient apparel is ... that is fluid repellant, breathable and in studies done ... of bacteria on the fabric i . ... the chain of transmission. We want myComfort to be ...
(Date:9/16/2014)... 16, 2014  Synereca Pharmaceutics, Inc. (SPI), ... active drugs that restore or increase the ... $1.4 million convertible debt financing. Accele Venture ... accelerator Accele Biopharma, Inc., led the financing ... recognized private not-for-profit corporation focused on growing ...
Breaking Medicine Technology:Evana Automation to Supply Robotic Assembly Cell to Leading Medical Device Manufacturer 2Evana Automation to Supply Robotic Assembly Cell to Leading Medical Device Manufacturer 3New Vestagen Patient Garments Aim to Minimize Pathogen Transmission Inside Hospitals 2Synereca Pharmaceuticals Announces Financing Led by Accele Venture Partners 2Synereca Pharmaceuticals Announces Financing Led by Accele Venture Partners 3Synereca Pharmaceuticals Announces Financing Led by Accele Venture Partners 4
... Council (NPC) today welcomed global specialty biopharmaceutical company Shire ... senior vice president, specialty pharma R&D, will serve as ... "The last few years have brought change ... important questions unresolved.  For the pharmaceutical industry, how ...
... Medical, Inc., a Minnesota-based medical device company, has announced that ... eripheral F acilitated A ntegrade S teering ... O cclusions (PFAST-CTOs) study.  The company received approval from ... US based IDE for the peripheral devices and is now ...
Cached Medicine Technology:National Pharmaceutical Council Welcomes Shire as Its Newest Member 2BridgePoint Medical Announces US IDE Approval and First Patient Enrollment of Peripheral Chronic Total Occlusion Study 2
The K-ASSAY® D-Dimer Control set is intended to be used a consistent test sample of known concentration for monitoring the performance of D-Dimer immunoturbidimetric assays....
Microalbumin Linearity Control...
Total IgE Control...
The K-ASSAY Lipid Controls are assayed controls produced from fresh human sera to monitor the accuracy and precision of quantitative lipid determinations of human sera specimens....
Medicine Products: