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Combination of imaging exams improves Alzheimer's diagnosis
Date:12/10/2012

ars.

The findings showed that combining MRI, FDG-PET and cerebrospinal fluid data with routine clinical tests significantly increased the accuracy of predicting conversion to Alzheimer's disease over clinical testing alone. In addition, the combined testing reduced false classifications. The misclassification rate decreased from 41.3 percent to 28.4 percent.

The researchers also analyzed the individual contributions of the various exams.

"In an ideal world, you'd obtain all information availableregardless of cost or number of testsfor the best prediction of cognitive decline," Dr. Petrella said. "However, there's a trade-off between adding testingsome of which may add little new informationwith the inconvenience, cost and risk to the patient."

Among the exams, FDG-PET contributed more information to routine tests than did cerebrospinal fluid or MRI.

"Though all the tests added some unique information," Dr. Petrella said, "FDG-PET appeared to strike the best balance, adding the most prognostic information for patients with mild cognitive impairment."

The researchers caution that additional long-term studies are needed to further validate the data.

ADNI was launched in 2003 and is a national, multi-site study of elderly patients with and without Alzheimer's disease and MCI. ADNI is the result of efforts of many co-investigators from academic institutions and private corporations. Patients were recruited from over 50 sites across the U.S. and Canada.


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Contact: Linda Brooks
lbrooks@rsna.org
630-590-7762
Radiological Society of North America
Source:Eurekalert

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