Navigation Links
Combination of imaging exams improves Alzheimer's diagnosis

OAK BROOK, Ill. A combination of diagnostic tests, including imaging and cerebrospinal fluid biomarkers can improve prediction of conversion from mild cognitive impairment (MCI) to Alzheimer's disease, according to a new study published online in the journal Radiology.

"Because new treatments are likely to be most effective at the earliest stages of Alzheimer's disease, there is great urgency to develop sensitive markers that facilitate detection and monitoring of early brain changes in individuals at risk," said Jeffrey R. Petrella, M.D., associate professor of radiology, division of neuroradiology, and director of the Alzheimer's Disease Research Lab at Duke University Medical Center (DUMC) in Durham, N.C. "Our study looks at whether more sophisticated diagnostic tests such as magnetic resonance imaging (MRI), positron emission tomography (PET) and spinal fluid protein analysis might provide additional prognostic information, compared to more readily available cognitive and blood testing."

According to the World Health Organization, more than 35 million people worldwide are living with Alzheimer's disease, which is incurable, and the prevalence is expected to double by 2030.

"Although there is no cure for Alzheimer's disease, there are four symptomatic treatments that might provide some benefits," said coauthor P. Murali Doraiswamy, M.D., professor of psychiatry at DUMC. "So developing the right combination of diagnostic tests is critical to make sure we enable an accurate and early diagnosis in patients, so they can evaluate their care options."

The Duke study looked at 97 patients with MCI from the Alzheimer's Disease Neuroimaging Initiative (ADNI), a national multicenter biomarker study in which patients are followed serially to track disease progression. The researchers analyzed baseline MRI and FDG-PET results, as well as cerebrospinal fluid proteins and compared these to cognitive outcomes at two to three years.

The findings showed that combining MRI, FDG-PET and cerebrospinal fluid data with routine clinical tests significantly increased the accuracy of predicting conversion to Alzheimer's disease over clinical testing alone. In addition, the combined testing reduced false classifications. The misclassification rate decreased from 41.3 percent to 28.4 percent.

The researchers also analyzed the individual contributions of the various exams.

"In an ideal world, you'd obtain all information availableregardless of cost or number of testsfor the best prediction of cognitive decline," Dr. Petrella said. "However, there's a trade-off between adding testingsome of which may add little new informationwith the inconvenience, cost and risk to the patient."

Among the exams, FDG-PET contributed more information to routine tests than did cerebrospinal fluid or MRI.

"Though all the tests added some unique information," Dr. Petrella said, "FDG-PET appeared to strike the best balance, adding the most prognostic information for patients with mild cognitive impairment."

The researchers caution that additional long-term studies are needed to further validate the data.

ADNI was launched in 2003 and is a national, multi-site study of elderly patients with and without Alzheimer's disease and MCI. ADNI is the result of efforts of many co-investigators from academic institutions and private corporations. Patients were recruited from over 50 sites across the U.S. and Canada.


Contact: Linda Brooks
Radiological Society of North America

Related medicine news :

1. Drug combination acts against aggressive chronic lymphocytic leukemia
2. Scientists test 5,000 combinations of 100 existing cancer drugs to find more effective treatments
3. Combination treatment may improve survival of breast cancer patients with brain metastases
4. Drug combination against NRAS-mutant melanoma discovered
5. Combination peptide therapies might offer more effective, less toxic cancer treatment
6. DNDi and Cipla to develop 4-in-1 pediatric antiretroviral drug combination
7. BUSM in vitro study identifies potential combination therapy for breast cancer
8. Moffitt Cancer Center researchers test drug combinations to prevent graft vs. host disease
9. Discovery suggests new combination therapy strategy for basal-like breast cancers
10. Cancer vaccine combination therapy shows survival benefit in breast cancer
11. Combination of 2 drugs reverses liver tumors
Post Your Comments:
(Date:11/25/2015)... ... November 25, 2015 , ... For the first time, Vitalalert ... Organizations, One Beat ” campaign. The partnership between the two groups began in 2014 ... MAP International’s cause. , MAP International was founded in 1954 and is an international ...
(Date:11/25/2015)... ... ... On November 25, 2015, officials of Narconon Arrowhead , the drug rehabilitation ... new cutting edge recovery program that has been 50 years in the making. ... with the purpose to free addicts from the symptoms and negative behaviors of addiction. ...
(Date:11/25/2015)... ... ... Smiles by Stevens is pleased to announce the addition of Botox® for ... aware of the benefits of Botox® in the treatment of moderate facial wrinkling, few ... and pain as a result of Jaw Tension, TMJ (temporo-mandibular joint) disorder, and Bruxism ...
(Date:11/25/2015)... ... November 25, 2015 , ... In an ongoing Clinical Study conducted by an ... IL, UV Angel is evaluating the efficacy of its product and its disinfection protocol. ... 30 beds) from May 2014 through October 2015 at a 360-bed, acute-care, academic medical ...
(Date:11/25/2015)... Spring, Md (PRWEB) , ... November 25, 2015 ... ... Pulmonary Hypertension Association (PHA) announces the nation’s Periwinkle Pioneers, individuals and groups responsible ... history of this disease. The Periwinkle Pioneers, nominated by the public, will receive ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... 2015 Kitov Pharma ceuticals ... a biopharmaceutical company focused on the development of therapeutic ... today announced the closing of its previously announced underwritten ... ), each representing 20 ordinary shares of the Company, ... ADSs and warrants were issued in a fixed combination ...
(Date:11/25/2015)...  Today AVACEN Medical announced the issue of United States patent No. ... ". This patent shields the company,s AVACEN 100 dry heat therapy medical device and specific methods ... Photo - ... ... ...
(Date:11/25/2015)... , Nov. 25, 2015 USP 800 ... drug preparations (e.g. pharmacists, pharmacy technicians, nurses, physicians, ... technicians). The chapter also covers all entities which ... pharmacies, hospitals, other healthcare institutions, patient treatment clinics, ... --> --> What is ...
Breaking Medicine Technology: