Navigation Links
Combination of available tests helps predict Alzheimer's disease risk
Date:10/20/2011

With age, forgetfulness and other signs of memory loss sometimes appear, prompting elderly individuals to seek a medical evaluation amid fears that they may be experiencing early symptoms of Alzheimer's disease (AD), the most common type of dementia among Americans aged 65 and older.

But even when early memory problems suggest the potential for impending AD, the actual risk is variable. Some patients are at high risk while others are not. The challenge for doctors has long been to differentiate that risk so they can determine the appropriate course of management.

In a paper to be published in the October 25 issue of the journal Neurology, a team of physicians and scientists from the University of California, San Diego School of Medicine and elsewhere describe using a combination of broadly available medical tests to produce a much improved predictive picture of the likelihood of impending AD in patients with mild cognitive impairment (MCI) an intermediate stage between the expected cognitive decline of normal aging and the more pronounced decline of dementia.

"I'm extremely excited about these results," said neurologist James Brewer, MD, PhD, an associate professor of radiology and neurosciences and part of the Alzheimer's Disease Neuroimaging Initiative research team at UC San Diego. "The good news is that we can partially reassure those folks who are negative on these tests, at least regarding their next three years. We have never been able to do that before. These individuals, despite having a real memory problem, have no greater risk of near-term dementia than a similarly aged healthy person without a memory complaint."

To determine the likelihood of developing Alzheimer's disease, the UC San Diego researchers compared risk factors based on magnetic resonance imaging (MRI), cerebrospinal fluid (CSF) and neuropsychological testing. Unlike other efforts that have evaluated the predictive capabilities of research-based biomarkers, MRI, CSF and neuropsychological tests are all technologies widely available to clinicians.

The researchers found that these available biomarkers significantly improved accuracy in predicting near-term conversion to dementia. In combination, their prediction rate was almost perfect: None of the individuals who tested negative on all three measures went on to develop AD in the three-year follow-up. By comparison, almost 90 percent of individuals who tested positive on all three measures were demented at the end of three years.

The presence of medial temporal atrophy, determined by automated analysis of MRI using an FDA-approved software package, was associated with the likeliest chance of near-term dementia, with a median dementia-free survival time of only 15 months.

Brewer said the findings foretell a paradigm shift in the diagnosis of Alzheimer's disease.

"Instead of saying, 'Let's wait a year and see if this gets worse,' our neurologists can say, 'Let's get a volumetric MRI and check back in a month to see if your complaint is due to neurodegeneration.' That ability makes a huge difference in how we proceed. Maybe the memory complaint isn't due to neurodegeneration, but rather it's a side effect of a medication, a sign of depression or someone is simply anxious and worried. Being able to reassure at least some patients that they are not at significant near-term risk of AD is something we never could do in the past, given the high prevalence of the disease."


'/>"/>

Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Related medicine news :

1. Combination therapies for drug-resistant cancers
2. Combination therapy beneficial for head and neck skin carcinomas, UNC study shows
3. Phase II study shows new cancer drug combination significantly delays breast cancer progression
4. Shorter treatment with hepatitis C drug combination may be more beneficial, study shows
5. Combination therapy rids common infection from implanted medical devices
6. Metformin and exercise combination less effective for glucose control
7. Combination of existing safety checks could greatly reduce radiotherapy errors
8. Hypnosis/local anesthesia combination during surgery helps patients, reduces hospital stays
9. Combination antibody therapy shows promise in metastatic melanoma
10. Combination therapy shows promise for rare, deadly cancer caused by asbestos
11. Less toxic combination of erlotinib and bevacizumab is effective non-small cell lung cancer patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... 2016 , ... Comfort Keepers® of San Diego, CA is excited to announce ... program to drive cancer patients to and from their cancer treatments. Comfort Keepers ... of life and ongoing independence. Getting to and from medical treatments is one ...
(Date:6/24/2016)... ... June 24, 2016 , ... Puradigm® ... Group (TGIG), has initiated cultivation and processing operations at its production facility, and ... Nevada. , Puradigm is the manufacturer of a complete system of proactive air ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... is supporting the upcoming 2016 Miss Arizona pageant as its official Medspa Sponsor. ... Scottsdale, Tempe, Mesa, and Chandler, Arizona. , Dr. Olson says the decision ...
(Date:6/24/2016)... AZ (PRWEB) , ... June 24, 2016 , ... SpiritQuest ... the heart of West Sedona, surrounded by famous vortex sites: Cathedral Rock, Airport Mesa, ... from partner properties – the Lodge at Sedona as well as the Sedona Rouge, ...
(Date:6/23/2016)... TX (PRWEB) , ... June 23, 2016 , ... The ... and business clients throughout Jasper County and the surrounding region, is initiating a charity ... charity drive will raise funds earmarked for a scholarship fund that will be presented ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- Roche (SIX: RO, ROG; OTCQX: RHHBY) announced that ... PCT (procalcitonin) assay as a dedicated testing solution for ... clearance, Roche is the first IVD company in the ... risk assessment and management. PCT is a ... in blood can aid clinicians in assessing the risk ...
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... "Key Pharma News Issue 52" report to their offering. ... need in influenza treatment creates a favourable commercial environment for ... and growing patient base that will serve to drive considerable ... flu vaccine would serve to cap sales considerably, but development ...
(Date:6/23/2016)... PARK RIDGE, Ill. and INDIANAPOLIS ... caliber of students receiving a Lilly Diabetes Tomorrow,s Leaders ... hands. The 2016 scholarship winners, announced today online at ... refused to let type 1 diabetes stand in the ... Lilly Diabetes has supported the Foundation,s scholarship program since ...
Breaking Medicine Technology: