Navigation Links
Combination of 2 drugs reverses liver tumors
Date:5/2/2012

The combination of two inhibitors of protein mTOR stops the growth of primary liver cancer and destroys tumour cells, according to a study by researchers of the Group of Metabolism and Cancer at Bellvitge Biomedical Research Institute (IDIBELL). The study results are been published on the online edition of the journal Science Translational Medicine.

Primary liver cancer or hepatocellular carcinoma is the fifth most common cancer and, due to its aggressiveness, is the third most deadly. It affects half a million people worldwide. Two of every three cases are related to chronic alcoholism, the exposure of toxic agents or infection with hepatitis B or C. The remaining third is related to non-alcoholic steatohepatitis, a disease related to obesity.

Promising candidates

Currently, the antitumor sorafenib shows the better patient outcomes, but its effectiveness decreases over time. For this reason, it is necessary to find new therapies. Among the most promising candidates are the inhibitors of the mTOR signalling pathway, which is hyperactivated in half of those affected by hepatocellular carcinoma.

The study led by IDIBELL researchers compared the effects in mice of two inhibitors of mTOR. The first was a derivative of rapamycin, called everolimus (RAD001), which is already used as an immunosuppressant and to treat specific cancers. The second is a new generation drug that inhibits mTOR called BEZ235.

During the study, researchers found unexpectedly that the combination of the two drugs had a more potent effect than any of the two drugs separately. Coadministration of BEZ235 and RAD001 limits the development of tumour and causes the self-destruction of tumour cells.

Based on these results a clinical trial, funded by Novartis, has started in the United States to evaluate the efficacy of the combination of these two inhibitors of mTOR in humans. The study coordinator, Sara Kozma, noted that "because r
'/>"/>

Contact: Jordi Morato
jmorato@idibell.cat
IDIBELL-Bellvitge Biomedical Research Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. WHI data confirm short-term heart disease risks of combination menopausal hormone therapy
2. Combination therapy more effective for enlarged prostate
3. Combination Treatment May Help Depressed Alcoholics
4. Researchers find new chemotherapy combination shows promise in endometrial cancer
5. Leeza Gibbons and ZERONA Equals a Winning Combination
6. Combination antibiotics effective against chlamydia-induced arthritis
7. Hair Loss Doctor Overcomes Odds To Produce First Ever Combination Topical Hair Growth Formula
8. Combination therapy targets stubborn leukemia stem cells
9. Combination treatment regimen not effective against advanced melanoma
10. New combination effective against pancreatic cancer
11. Noninvasive combination technique may reduce number of breast biopsies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/12/2014)... (PRWEB) July 12, 2014 ... & Peripheral Vascular Devices Market by ... Drug-Eluting), Catheter (IVUS, OCT), IVC Filter ... to 2018" analyzes and studies the ... in the U.S. and Canada. , ...
(Date:7/12/2014)... New York, New York (PRWEB) July 12, 2014 ... involving liver damage allegations continue to move forward ... District Court, Eastern District of Pennsylvania, Bernstein Liebhard ... 1, 2014, U.S. District Judge Lawrence F. Stengel ... president. Among other things, Judge Stengel found that ...
(Date:7/12/2014)... Sean Francis, owner of the Kawartha Lakes Fit ... his clients. He’s also known for his support of local non-profits ... to combine the two and is excited to announce that his ... and Girls Club. , The funds are the result of Francis’ ... Francis sent out emails and asked his clients to put out ...
(Date:7/12/2014)... (PRWEB) July 12, 2014 For those who ... bodies can readily absorb the nutrients in food. The enzymes ... that are small enough to be absorbed by human bodies. ... a lack of enzymes in regular food is the cause ... product that was started by Michelle DelPresto, a mother of ...
(Date:7/12/2014)... 2014 Utah Valley Entrepreneurial Forum Top ... awards being bestowed to companies in revenue, and pre-revenue ... community with recognition for new ideas as well as ... revenue. , 25 Under 5 highlights outstanding Utah entrepreneurs ... under 5 years old. Award recipients were recognized at ...
Breaking Medicine News(10 mins):Health News:North American Interventional Cardiology & Peripheral Vascular Devices Market - New Report by MarketsandMarkets 2Health News:North American Interventional Cardiology & Peripheral Vascular Devices Market - New Report by MarketsandMarkets 3Health News:North American Interventional Cardiology & Peripheral Vascular Devices Market - New Report by MarketsandMarkets 4Health News:North American Interventional Cardiology & Peripheral Vascular Devices Market - New Report by MarketsandMarkets 5Health News:Tylenol Lawsuit News: U.S. District Judge Overseeing Federal Tylenol Liver Damage Litigation Orders Deposition of Former McNeil President, Bernstein Liebhard LLP Reports 2Health News:Tylenol Lawsuit News: U.S. District Judge Overseeing Federal Tylenol Liver Damage Litigation Orders Deposition of Former McNeil President, Bernstein Liebhard LLP Reports 3Health News:Tylenol Lawsuit News: U.S. District Judge Overseeing Federal Tylenol Liver Damage Litigation Orders Deposition of Former McNeil President, Bernstein Liebhard LLP Reports 4Health News:Kawartha Lakes Fit Body Boot Camp’s Successful Fat Loss Challenge Results in $2,000 to Boys and Girls Club 2Health News:Kawartha Lakes Fit Body Boot Camp’s Successful Fat Loss Challenge Results in $2,000 to Boys and Girls Club 3Health News:New Super Digestive Enzyme, DZ10, Supercharges The Digestion Process 2Health News:SquareHook is Recognized for UVEF 25 Businesses Under 5 Years-Watch Out 2
... defend title as 238 runners with 33 corporate teams compete ... speed, size, and spirit categories this Sunday, ... Valley Marathon(R) announced today that the field for the third,annual ... 33 corporate teams competing. (Logo: http://www.newscom.com/cgi-bin/prnh/20010807/CMALOGO ) ...
... For millions of Americans the benefits,of aspirin go ... "low dose" aspirin can help prevent one out ... many people on aspirin therapy who take other ... to this report from Bayer at:, http://media.medialink.com/WebNR.aspx?story=34050 ...
... Nov. 2 /PRNewswire-FirstCall/ - The Westaim Corporation,announced today the ... credit line of $12.6 million from a major financial ... and will be secured by the,equivalent value of asset-backed ... announced that it held $19.7 million in ABCP. In,September, ...
... Consumer Behavior Is Focus of,Presentation at Association of ... NEW YORK, Nov. 2 Using,knowledge from neurosciences ... consumers, brains to gauge their response to commercials ... at Lapiz,says there are dangers in looking for ...
... YORK, Nov. 2 Recent outbreaks of,antibiotic-resistant Staphylococcus aureus, more ... A bacteria that healthy people,can carry on the skin or ... cause infections of the skin, in the blood, in the ... a wide range of antibiotics.,While most of these infections are ...
... (Amex: PTN ) today announced that it will ... Healthcare Conference at the New York Palace,Hotel in New ... ET. Carl Spana, Ph.D., President and Chief Executive ... Company,s corporate and,development programs. To access the live audio ...
Cached Medicine News:Health News:Biggest Field Ever to Compete Nov. 4 for 'Fastest Company in Silicon Valley' Title in the Comerica Corporate Challenge at The 2007 Metro Silicon Valley Marathon(R) 2Health News:Biggest Field Ever to Compete Nov. 4 for 'Fastest Company in Silicon Valley' Title in the Comerica Corporate Challenge at The 2007 Metro Silicon Valley Marathon(R) 3Health News:The Westaim Corporation update on status of short-term investments 2Health News:Exploring the Use of Techniques From Neuroscience in Today's Marketing 2Health News:Exploring the Use of Techniques From Neuroscience in Today's Marketing 3
(Date:7/11/2014)... 11, 2014 The consumer marketing playbook ... industry sectors to better identify winning tools and ... engage with and understand consumers, as new technologies ... critical purchasing decisions. According to ... one area where organizations can observe a deep ...
(Date:7/11/2014)... , July 11, 2014  Kindred Hospital ... to announce the opening of its new outpatient ... outpatient services to people with chronic, hard to ... which can lead to amputation, lower leg wounds ... have delayed closure, and traumatic injury wounds which ...
(Date:7/11/2014)... LOUIS , July 11, 2014 /PRNewswire/ ... device company, announced today the positive, cost-effective ... its innovative SPiNPerc™ procedure. The SPiNPerc endobronchial ... of a percutaneous approach to biopsy when ... Hospitals, patients and physicians experience positive financial ...
Breaking Medicine Technology:New Technologies Transforming Consumer Marketing Research Playbook 2Kindred Hospital Houston Northwest, With Wound Care Specialists, Opens Outpatient Wound Healing And Hyperbaric Center 2Veran Medical Publishes Lung Cancer Patient Management Study 2
... ... , ATLANTA, Georgia, November 30 ... managed in partnership by MC Strategies/Elsevier and the, University of Minnesota,s ... on "Cerebral Palsy" is now,available for administrators and learners to use as ...
... 30 Middle-aged men and women who engage in high ... their knees and increasing their risk for osteoarthritis, according to ... Radiological Society of North America (RSNA). , "Our data suggest ... greater risk for developing knee abnormalities and, thus, at higher ...
Cached Medicine Technology:Cerebral Palsy Course Strengthens CDS Curriculum as Second Disability Intensive Course Offering 2Cerebral Palsy Course Strengthens CDS Curriculum as Second Disability Intensive Course Offering 3Too Much Physical Activity May Lead to Arthritis 2Too Much Physical Activity May Lead to Arthritis 3
Ernest nucleus cracker extra delicate cross-action serrated paddle shaped jaws for cracking the nucleus through a 2.5 mm incision....
Epilation forceps angled ends size 3.5"....
Forceps, extra delicate, straight....
Jewelers Forceps, delicate, straight....
Medicine Products: