Navigation Links
Combination epigenetic therapy clinical trial results
Date:11/10/2011

A new type of therapy aimed at reversing the gene-silencing that promotes cancer-cell growth has shown promising results in a small clinical trial conducted by researchers at the Johns Hopkins Kimmel Cancer Center. Forty-five late-stage lung cancer patients who received a two-drug combination designed to restore anti-cancer gene activity survived about two months longer than the expected four months, and two patients showed complete or near-complete responses despite having progressive disease after multiple standard therapies.

In the study, reported in Cancer Discovery on Nov. 9, 2011, the Hopkins researchers treated non-small-cell lung cancer patients with a combination of the drugs azacitidine and entinostat. Azacitidine removes methyl groups from genes; entinostat inhibits histone deacetylation, a closely related process that also contributes to gene-silencing.

"We hope these results lead to a larger, more definitive clinical trial of this drug combination," says Charles Rudin, M.D., Ph.D., professor of oncology and director of the Upper Aerodigestive Cancer Program at Hopkins' Kimmel Cancer Center. Rudin led the team of physicians and cancer biologists who conducted the study.

It is believed to be one of the first to show promising results for "epigenetic" anti-cancer therapies in solid tumors. Johns Hopkins researchers previously tested the drug combination in leukemia patients. Laboratory results suggest that epigenetic treatments aim not to kill cancer cells directly but instead may reprogram their patterns of gene expression so that they lose their capacity for uncontrolled growth. A normal cell has a specific pattern of gene expression, in which some genes are active and others are suppressed, and a derangement of this pattern frequently contributes to cancer, in part by silencing genes whose activity would normally stop a cell from becoming cancerous. Cancer cells also have permanent genetic mutations, which cann
'/>"/>

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. NYUCN receives $2.8 million NIH/NIAID grant to study combination HIV prevention for Kenyan youth
2. Combination of available tests helps predict Alzheimers disease risk
3. Combination therapies for drug-resistant cancers
4. Combination therapy beneficial for head and neck skin carcinomas, UNC study shows
5. Phase II study shows new cancer drug combination significantly delays breast cancer progression
6. Shorter treatment with hepatitis C drug combination may be more beneficial, study shows
7. Combination therapy rids common infection from implanted medical devices
8. Metformin and exercise combination less effective for glucose control
9. Combination of existing safety checks could greatly reduce radiotherapy errors
10. Hypnosis/local anesthesia combination during surgery helps patients, reduces hospital stays
11. Combination antibody therapy shows promise in metastatic melanoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... Salt Lake City, Utah (PRWEB) August 20, 2014 ... House Awning & Canvas Products, announces the availability ... extension of the company’s ordering capabilities aims to ... features Sugar House Awning’s complete line of canvas ... most major brands including Bryant, Lennox, Rheem, Payne, ...
(Date:8/20/2014)... 2014 Recently, UWDress.com, the distinguished wedding ... of birthday party dresses for girls . According ... well-designed and exquisitely handmade by experienced specialists. Now, they ... off. , The company’s new items come in various ... knee length frocks, long elegant backless gowns and so ...
(Date:8/20/2014)... Top10BestSEOHosting.com is a website dedicated to ... It is headed by a team of experts ... research-based information and factual studies about the newest ... market. , Recently, Top10BestSEOHosting.com has compared many ... and Bluehost are the most recommended suppliers ...
(Date:8/20/2014)... Park Avenue Dental, a leading Florida-based dental ... top graduate of the University of Detroit School of ... website through an ultra-informative blog focused on dental tips ... the blog page is chock full of topics that ... concentrating on important dental care tips including ...
(Date:8/20/2014)... 20, 2014 Today, Zane Benefits, ... publication of a new eBook, Affordable Care Act ... business owners feel uncertain about how the ACA ... their bottom line. , The new eBook outlines ... businesses navigate their upcoming health insurance decisions. , ...
Breaking Medicine News(10 mins):Health News:Air Conditioner Covers for Most A/C Units Now Available Online at Coolercovers.com and Amazon.com 2Health News:Air Conditioner Covers for Most A/C Units Now Available Online at Coolercovers.com and Amazon.com 3Health News:Cheap Birthday Party Dresses for Girls Now Available at UWDress.com 2Health News:New Reviews For Linux Web Hosting Suppliers Announced By Top10BestSEOHosting.com 2Health News:Park Avenue Dental Provides Dental Care Tips for World Wide Community on New Website Blog 2Health News:Park Avenue Dental Provides Dental Care Tips for World Wide Community on New Website Blog 3
... injection into a collection of nerves in the neck ... frequency of debilitating hot flashes and night awakenings associated ... published online today by The Lancet Oncology and appearing ... dysfunctions often plague breast cancer survivors, especially those who ...
... WASHINGTON, May 14 The following was,released by the ... Obama:, "NARAL Pro-Choice America PAC Is Excited To ... 2008. Sen. Obama Has A Fully Pro-Choice,Record, And We ... Champion For,Women,s Reproductive Rights." (NARAL Website, "Elections," http://www.naral.org, ...
... Center, Emory University, have discovered the first conclusive ... aged nonhuman primate. The unprecedented finding, described in ... Neurology, has the potential to move the scientific ... neurodegenerative diseases, such as Alzheimer,s disease, are uniquely ...
... Mergent, Inc., administrator for the,HealthShares(TM) Indexes, a ... Traded Funds, today announced the following,changes with effect ... 19, 2008:,Genzyme Corporation (Nasdaq: GENZ ) will ... Index, Ligand Pharmaceuticals Inc.,(Nasdaq: LGND ) will ...
... They contain same toxins as cigarettes, but users think ... News) -- The increasing use of waterpipes, or ... public health problem, according to a Virginia Commonwealth University ... and the smoke is cooled by passing through a ...
... can lead to muscle spasms, fever, sweating and nausea, ... A commonly used migraine medication may cause so-called serotonin ... in the May 15 issue of the New ... and the U.S. Food and Drug Administration detail 11 ...
Cached Medicine News:Health News:'Cool' new treatment for hot flashes in breast cancer survivors 2Health News:'Cool' new treatment for hot flashes in breast cancer survivors 3Health News:NARAL'S CHOICE: Is Anyone Surprised About Out-of-the-Mainstream NARAL's Choice of Barack Obama for President? 2Health News:NARAL'S CHOICE: Is Anyone Surprised About Out-of-the-Mainstream NARAL's Choice of Barack Obama for President? 3Health News:Researchers find first conclusive evidence of Alzheimer's-like brain tangles in nonhuman primates 2Health News:Researchers find first conclusive evidence of Alzheimer's-like brain tangles in nonhuman primates 3Health News:Mergent, Inc. Announces Changes to the HealthShares(TM) Composite Index, HealthShares(TM) Dermatology and Wound Care Index and HealthShares(TM) Orthopedic Repair Index 2Health News:Mergent, Inc. Announces Changes to the HealthShares(TM) Composite Index, HealthShares(TM) Dermatology and Wound Care Index and HealthShares(TM) Orthopedic Repair Index 3Health News:Waterpipe Smoking in Colleges Could Become Public Health Problem 2Health News:Migraine Medications May Cause 'Serotonin Syndrome' 2Health News:Migraine Medications May Cause 'Serotonin Syndrome' 3
(Date:8/20/2014)... 20, 2014 ApolloDx™ today announced it will ... a special event at the company,s office in ... 5, 2014. The event, which will start at 10:00 ... www.apollodx.com .    "We believe our ... Jared Bauer , Co-Founder and Managing Partner of ApolloDx. ...
(Date:8/20/2014)... DIEGO , Aug. 20, 2014 Trovagene, ... diagnostics, announced today that results from two clinical studies ... conference for the Company,s urine-based diagnostic test for the ... The IPV conference is scheduled to take place in ... to 25 th . Additionally, a new U.S. ...
(Date:8/20/2014)... August 20, 2014 Phase I ... the US  KalVista Pharmaceuticals ("KalVista"), an ophthalmology ... today announces that it has begun a Phase I, ... inhibitor, KVD001, for the treatment of DME. The study,s ... Beetham Eye Institute, Joslin Diabetes Center; Harvard Medical School ...
Breaking Medicine Technology:Trovagene Provides Update on Its Urine-Based HPV Test 2Trovagene Provides Update on Its Urine-Based HPV Test 3KalVista Pharmaceuticals Announces Start of Clinical Development for Novel Treatment for Diabetic Macular Edema 2KalVista Pharmaceuticals Announces Start of Clinical Development for Novel Treatment for Diabetic Macular Edema 3KalVista Pharmaceuticals Announces Start of Clinical Development for Novel Treatment for Diabetic Macular Edema 4
... Therapies, Inc. (ITI),today announced it has initiated a ... its drug candidate ITI-722. ITI-722 acts predominantly,as a ... new,approach to the treatment of SMI. Because of ... activities, ITI believes, ITI-722 can be,used not only ...
... GeoVax Labs, Inc. (OTC,Bulletin Board: GOVX), an ... it has retained Financial,Relations Board (FRB), as its ... promising HIV-1/AIDS vaccine human trial results need to ... catastrophic AIDS,pandemic," stated Kathy Waller, co-president of FRB., ...
Cached Medicine Technology:Intra-Cellular Therapies Initiates Phase 2 Clinical Trial for Sleep Maintenance Insomnia 2Intra-Cellular Therapies Initiates Phase 2 Clinical Trial for Sleep Maintenance Insomnia 3Intra-Cellular Therapies Initiates Phase 2 Clinical Trial for Sleep Maintenance Insomnia 4GeoVax Labs, Inc. Selects Financial Relations Board as Investor Relations Counsel 2GeoVax Labs, Inc. Selects Financial Relations Board as Investor Relations Counsel 3GeoVax Labs, Inc. Selects Financial Relations Board as Investor Relations Counsel 4
... concave seats and large backrests with ... seats, backrests, armrests, and casters and ... for top performance in a variety ... clean room, static control, health care ...
... chairs with concave seats and large backrests ... seats, backrests, armrests, and casters and glides. ... performance in a variety of environments including: ... health care and office. • With cast ...
... Durable ergonomic chairs with concave ... support • Select options like seats, ... • Choose the BE Series for ... environments including: industry, education, laboratory, clean ...
... chairs with concave seats and large backrests ... seats, backrests, armrests, and casters and glides. ... performance in a variety of environments including: ... health care and office. • With tubular ...
Medicine Products: