Navigation Links
Combination antibody therapy shows promise in metastatic melanoma
Date:6/3/2011

BOSTON--A duo of drugs, each targeting a prime survival strategy of tumors, can be safely administered and are potentially more effective than either drug alone for advanced, inoperable melanomas, according to a phase 1 clinical trial led by Dana-Farber Cancer Institute investigators.

The findings (abstract 8511), will be presented in an oral session at the annual meeting of the American Society of Clinical Oncology on Saturday, June 4, 3 p.m. CT, Arie Crown Theater, McCormick Place.

The drugs -- ipilimumab and bevacizumab -- are both monoclonal antibodies, intensified formulations of natural disease-fighting proteins. Ipilimumab spurs the immune system to attack diseased cells, including tumor cells. Bevacizumab, also known by the trade name Avastin, blocks the growth of blood vessels that provide tumors with nourishment. Ipilimumab has extended the lives of metastatic melanoma patients in previous clinical trials, and bevacizumab is often used to treat tumors of the colon, lung, and kidney.

The trial involved 22 patients with metatastic melanoma that was not treatable by surgery.

F. Stephen Hodi, MD, the study's lead author and director of the melanoma treatment center at Dana-Farber, said the trial is the first to explore whether the two agents enhance each other's effectiveness. Most of the participants didn't experience serious adverse side effects, although some did experience inflammation of artery walls, the liver, thyroid gland, colon, or uvea (the middle layer of the eye). Five patients required steroid treatment for these problems and were removed the trial.

Positron emission tomography (PET) scans showed a prompt immune system response to many of the melanoma tumors, and computed tomography (CT) scans showed decreased blood flow to the tumors. Eight of the participants had partial responses -- showing some tumor shrinkage -- to the dual treatment, and six had stable disease. All the responses lasted at least six months. Biopsies performed after the treatment showed a more vigorous immune system response than would be expected with ipilimumab alone.

"Our findings indicate that ipilimumab and bevacizumab can be safely administered with careful management of side effects," said Hodi. "The results of lab tests suggest that the two agents may work synergistically, with 14 of 21 evaluable patients experiencing a clinical benefit. This approach merits exploration in further clinical trials."


'/>"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
Source:Eurekalert

Related medicine news :

1. Combination therapy shows promise for rare, deadly cancer caused by asbestos
2. Less toxic combination of erlotinib and bevacizumab is effective non-small cell lung cancer patients
3. Model developed to improve combination vaccine accessibility worldwide
4. Gene combinations are found to be related to hip osteoporosis in postmenopausal women
5. Smoking in combination with immunosuppression poses greater risk for transplant-related carcinoma
6. Combination overcomes breast cancer resistance to herceptin
7. New combination therapy for solid tumors?
8. Certain Drug Combinations May Beat Back Aggressive Breast Cancer
9. Drug combination shows promise for newly diagnosed blood cancer patients, study finds
10. Combination therapy improves survival time for patients with advanced liver cancer
11. Best drug development results from computer/test tube combination
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/30/2016)... ... 30, 2016 , ... Create an abstract shape animation with ... manipulate three-dimensional shapes with ease all within Apple Motion . Users have ... texture animation, opacity texture animation, overall shape texture displacement, twist, camera controls, and ...
(Date:4/30/2016)... Cambridge, MA (PRWEB) , ... April 30, 2016 ... ... non-profit organization, today announced RANKED Health , a program to critically evaluate ... A major goal of the program is to provide independent, unbiased and accurate ...
(Date:4/30/2016)... Montego Bay, Jamaica (PRWEB) , ... April 30, ... ... Caribbean University, and Duane Boise, President and CEO of EMED, today signed a ... in Jamaica. , EMED and the Northern Caribbean University Department of Natural and ...
(Date:4/30/2016)... ... ... is a challenge for all of us, but there are things we can do to improve ... “Research is showing more and more that there are simple, yet important steps that can be ... Top priorities Dr. Kohli’s recommends for her patients include;, , exercise ...
(Date:4/29/2016)... ... April 30, 2016 , ... World Patent Marketing ... Up Springboard, an automotive invention that improves the storage features of a pick ... billion," says Scott Cooper, CEO and Creative Director of World Patent Marketing. "Over ...
Breaking Medicine News(10 mins):
(Date:4/29/2016)... , April 29, 2016 ... Directeur Financier Sanofi, leader ... publie ses résultats pour le premier ... Groupe, Jérôme Contamine, commente les résultats ... les perspectives pour le reste de ...
(Date:4/28/2016)...  While Abbott,s announced purchase of St. Jude ... and stent business, healthcare research firm Kalorama Information ... into patient monitoring.  Kalorama said that patient monitoring ... with double-digit growth expected the next 5 years, ... Patient Monitoring . Abbott Laboratories agreed to ...
(Date:4/28/2016)... NEW YORK , April 28, 2016  The ... reached 275 million dollars, according to Kalorama Information and ... includes typing, immunoassays and nucleic acid testing.  The healthcare ... had made progress in developing blood collection stations and ... was made in Kalorama Information,s report, Blood ...
Breaking Medicine Technology: