Navigation Links
Combination antibody therapy shows promise in metastatic melanoma
Date:6/3/2011

BOSTON--A duo of drugs, each targeting a prime survival strategy of tumors, can be safely administered and are potentially more effective than either drug alone for advanced, inoperable melanomas, according to a phase 1 clinical trial led by Dana-Farber Cancer Institute investigators.

The findings (abstract 8511), will be presented in an oral session at the annual meeting of the American Society of Clinical Oncology on Saturday, June 4, 3 p.m. CT, Arie Crown Theater, McCormick Place.

The drugs -- ipilimumab and bevacizumab -- are both monoclonal antibodies, intensified formulations of natural disease-fighting proteins. Ipilimumab spurs the immune system to attack diseased cells, including tumor cells. Bevacizumab, also known by the trade name Avastin, blocks the growth of blood vessels that provide tumors with nourishment. Ipilimumab has extended the lives of metastatic melanoma patients in previous clinical trials, and bevacizumab is often used to treat tumors of the colon, lung, and kidney.

The trial involved 22 patients with metatastic melanoma that was not treatable by surgery.

F. Stephen Hodi, MD, the study's lead author and director of the melanoma treatment center at Dana-Farber, said the trial is the first to explore whether the two agents enhance each other's effectiveness. Most of the participants didn't experience serious adverse side effects, although some did experience inflammation of artery walls, the liver, thyroid gland, colon, or uvea (the middle layer of the eye). Five patients required steroid treatment for these problems and were removed the trial.

Positron emission tomography (PET) scans showed a prompt immune system response to many of the melanoma tumors, and computed tomography (CT) scans showed decreased blood flow to the tumors. Eight of the participants had partial responses -- showing some tumor shrinkage -- to the dual treatment, and six had stable disease. All the responses lasted at l
'/>"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Combination therapy shows promise for rare, deadly cancer caused by asbestos
2. Less toxic combination of erlotinib and bevacizumab is effective non-small cell lung cancer patients
3. Model developed to improve combination vaccine accessibility worldwide
4. Gene combinations are found to be related to hip osteoporosis in postmenopausal women
5. Smoking in combination with immunosuppression poses greater risk for transplant-related carcinoma
6. Combination overcomes breast cancer resistance to herceptin
7. New combination therapy for solid tumors?
8. Certain Drug Combinations May Beat Back Aggressive Breast Cancer
9. Drug combination shows promise for newly diagnosed blood cancer patients, study finds
10. Combination therapy improves survival time for patients with advanced liver cancer
11. Best drug development results from computer/test tube combination
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... December 26, 2014 Recently, iFitDress.com, the popular ... women, has announced its new selection of black one-shoulder ... on sale now; they are available at discounted prices, up ... “The promotion will last for three weeks only. You know, ... Those who are interested in our new items can visit ...
(Date:12/25/2014)... 2014 Helen Harris’ RP (Retinitis Pigmentosa) ... California after an 8 year battle with breast cancer. ... evening in her home in Woodland Hills California after ... , As the founder and volunteer ... pioneered and championed many of today's greatest breakthroughs in ...
(Date:12/25/2014)... common during the holidays, but there are strategies that can ... arrive at a party hungry. It may seem logical to ... party, but deprivation leads to hunger, and hunger leads to ... Mount Kisco, N.Y., said in a hospital news release. ... to have a snack before attending a party when you ...
(Date:12/25/2014)... 25, 2014 “ SmileStix ” was featured ... the latest and coolest mobile applications on the iOS, Android, ... host of NewsWatch, conducted the app review and shared with ... personal stickers. , The old saying goes, “A picture says ... words that can describe a single image, because each picture ...
(Date:12/24/2014)... Wauwatosa, Wi (PRWEB) December 25, 2014 ... who are unable to afford certain items. During the holiday ... , "We collected over 70 toys," says Dr. Sara Mahalko-Leonhardt, ... myself and staff such joy, knowing that we are able ... any present had it not been for the generosity of ...
Breaking Medicine News(10 mins):Health News:iFitDress.com: Black One-Shoulder Cocktail Dresses for 2015 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 3Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 4Health News:An Application to Create Custom Stickers was Featured on NewsWatch Television on December 19, 2014 2Health News:AlignLife of Wauwatosa Brings Joy to Less Fortunate Families 2
... ... season, FORT WORTH, Texas, Nov. 13 ... Jude,during the 2008 holiday shopping season for the 5th anniversary of the,Thanks and ... RadioShack is asking customers to "Give thanks,for the healthy kids in your life, ...
... to emphasize smoking prevention for young girls has been ... Medical School (DMS). The safe, online patient education site ... prevent smoking in young girls 8-11 years old). , ... the siteNo Smoking Room.Org ( www.nosmokingroom.org ) is designed ...
... Nov. 13 NBTY, Inc. (NYSE:,NTY) (http://www.NBTY.com ), ... announced that Arthur Rudolph, its Founder,and a member of ... plan to sell a portion of his NBTY stock ... asset diversification and liquidity. The stock,trading plan was adopted ...
... (Nasdaq: AMLN ) will be presenting at the ... November,19, 2008 at 8:30 a.m. ET. Daniel M. Bradbury, ... providing a corporate overview., The live presentation will ... following the event. The Web cast and recording will ...
... $3.8 million Innovator Award, from the Department of Defense, ... renowned cancer researcher at the University of California, Santa ... is known for his innovative, interdisciplinary research. "This is ... them," said Ruoslahti. "I am very happy at being ...
... Nov. 13 Debiopharm Group,(Debiopharm), a global ... conditions and particularly oncology, today,announced that the ... month formulation,of Trelstar(R) (triptorelin pamoate) has been ... Food and Drug Administration (FDA). Trelstar(R) is ...
Cached Medicine News:Health News:RadioShack Partners With St. Jude Children's Research Hospital(R) on the 5th Anniversary of the Thanks and Giving(R) Campaign 2Health News:RadioShack Partners With St. Jude Children's Research Hospital(R) on the 5th Anniversary of the Thanks and Giving(R) Campaign 3Health News:Innovative new Web site empowers young girls to live smoke-free 2Health News:NBTY Founder Adopts Rule 10b5-1 Trading Plan 2Health News:Cancer researcher receives $3.8 million award from US Department of Defense 2Health News:Debiopharm Announces U.S. NDA Filing of Trelstar(R) 6-Month Formulation for Locally Advanced or Metastatic Prostate Cancer 2
(Date:12/24/2014)... , Dec. 23, 2014   Assurex Health, ... decision support to healthcare providers for behavioral health ... has secured $30 million in equity financing from ... C. Drosos , President and Chief Executive Officer. ... adoption and development of Assurex Health,s GeneSight ...
(Date:12/24/2014)... DUBLIN and RALEIGH, N.C. ... subsidiary of Endo International plc (NASDAQ: ENDP ... BDSI ) announced today that they have ... Buccal Film to the U.S. Food and Drug Administration ... the management of pain severe enough to require daily, ...
(Date:12/22/2014)... Dec. 22, 2014 Research and Markets ... "US Self-monitoring Blood Glucose Market" report to ... This market insight focuses on the developments ... the United States . Reimbursement analysis and the ... analyses for more than 73 SMBG meters have been ...
Breaking Medicine Technology:Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 2Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 3Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 4Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 2Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 3Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 4Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 5US Self-monitoring Blood Glucose Market 2
...   Syndax Pharmaceuticals, Inc ., a clinical-stage epigenetics oncology ... 2 clinical trials with entinostat in combination and as ... conferences.  San Antonio Breast Cancer ... randomized, double-blind, placebo-controlled, phase 2 study of exemestane with ...
...  Henry Schein, Inc., (NASDAQ: HSIC ), the ... office-based practitioners, announced today that Stanley Bergman, Chairman and ... the Company,s Executive Vice President and Chief Financial Officer, ... on December 6.  The conference is being held at ...
Cached Medicine Technology:Multiple Data Presentations on Syndax Pharmaceutical's Entinostat at Upcoming Scientific Conferences 2Multiple Data Presentations on Syndax Pharmaceutical's Entinostat at Upcoming Scientific Conferences 3Multiple Data Presentations on Syndax Pharmaceutical's Entinostat at Upcoming Scientific Conferences 4Multiple Data Presentations on Syndax Pharmaceutical's Entinostat at Upcoming Scientific Conferences 5Henry Schein to Present at the NASDAQ OMX 27th Investor Program 2
DCR Set, Angled....
... The Leica CM3050 S Cryostat ... with excellent safety standards for ... applications. The Leica CM3050 S ... for all cryosectioning research applications ...
... The Bright 7500 is a freestanding ... liquid decontamination system and a radial ... to cut a wide range of ... effective for use in high biohazard ...
... - a vision becomes reality. Numerous ... the users many benefits.,The Cryo-Star is ... retraction that incorporates a unique refrigeration ... cooling. This facilitates applications in both ...
Medicine Products: