Navigation Links
Combating a crisis: Global burden of preterm birth can be reduced if critical actions are taken

New surveys of researchers and funders reveal a lack of consensus regarding researching and developing interventions to prevent prematurity and stillbirth, according to an article published in the American Journal of Obstetrics and Gynecology ahead of World Prematurity Day on November 17.

Authored by Michael G. Gravett, MD, scientific director of the Global Alliance to Prevent Prematurity and Stillbirth (GAPPS), an initiative of Seattle Children's, and Craig E. Rubens, MD, PhD, executive director of GAPPS, the article outlines significant opportunities to enhance research into pregnancy complications and develop solutions to prevent prematurity and stillbirth, which combined take the lives of 4 million babies every year.

"One of the main observations from the technical team was that current research funding is fragmented and uncoordinated, lacking central leadership," the authors write in A framework for strategic investments in research to reduce the global burden of preterm birth. "Funders do not understand where the field is going."

Gravett and Rubens surveyed researchers and funders and found that both parties are equally uncertain about research and development projects that need to be undertaken, and many funders are hard-pressed to support research on the complex problems of pregnancy and childbirth given competing priorities. This lack of consensus provides an opportunity to engage with funders and researchers to recognize the importance of understanding healthy pregnancies and the consequences of adverse pregnancy outcomes.

The article proposes that a strategic alliance of funders, researchers, nongovernmental organizations, the private sector, and others could organize a set of grand challenges centered on pregnancy and childbirth that could yield a substantial improvement in the development and delivery of new and much more effective interventions, even in low-resource settings.

The authors note: "Pregnancy remains one of the least explored aspects of human biology, creating a tremendous opportunity. Long-term funding commitments for research could advance discovery science and the development of interventions targeted at pregnancy and early life and impact maternal and newborn health around the world."

Preterm birth and stillbirth are among the greatest health burdens associated with pregnancy and childbirth. Fifteen million babies are born preterm each year, causing about 1 million deaths annually and lifelong problems for many survivors; 3 million stillbirths also occur annually. Worldwide, the number of women and children who die during pregnancy and childbirth exceeds the total number of births in the United States. Even if all current interventions were universally applied, the authors estimate that the preterm birthrate would drop by less than 20 percent.

Based on their interviews, the authors compiled a set of recommendations that could greatly improve the visibility of research on pregnancy, childbirth, and early life, and mobilize funders to increase investments leading to the discovery, development, and delivery of low-cost and high-impact interventions to prevent preterm birth and stillbirth.

Toward making every pregnancy a healthy pregnancy:

  • Emphasize that healthy outcomes in pregnancy benefit everyone, directly and indirectly

  • Raise awareness of personal and public burden of prematurity, stillbirth, and other pregnancy and early life problems

  • Establish strategic alliance of funders, researchers, and other stakeholders in areas of pregnancy, childbirth, and early life

  • Identify commonalities among funding organizations to develop a coordinated research and intervention agenda

  • Identify and promote research opportunities in areas of pregnancy, childbirth, and early life that can attract investigators

  • Engage new investigators from multiple disciplines

  • Utilize descriptive sciences and economic modeling to establish true costs and burdens of disease and assess impact of costs of current or future interventions

  • Establish collaborations and promote research within high-burden, low-resource countries

Key considerations in developing a framework for a global approach to reduce preterm birth and stillbirth:

  • Develop and adopt clear and consistent definitions and classification criteria

  • Longitudinally characterize determinants of healthy continuum pregnancy and pathologic perturbations

  • Recognize preterm birth and stillbirth as multifactorial, complex endpoints

  • Develop predictive biomarkers and interventions that are pathway-specific for varied causes of preterm birth and stillbirth

  • Develop infrastructure to support population-specific research and intervention in high-burden, low-resource settings

  • Link discovery science to intervention development and implementation science

Contact: Casey Calamusa
Seattle Children's

Related medicine news :

1. Plastic and Reconstructive Surgery Journal announces global expansion initiatives
2. $20 million gift launches new hub for global health at UCSF
3. Cardiovascular disease community calls for tougher targets to curb global risk
4. 2012 Pacific Global Health Conference
5. NTU and University of Warwick boost brainpower in global neuroscience research
6. Local talent: Global impact public invited to meet world-class researchers at Queens
7. Funding for neglected global diseases research at UBC exceeds $20 million
8. Premier global health journal, The Lancet, releases series on universal health coverage
9. Global platelet reactivity identifies high risk ACS patients
10. Global platelet reactivity and high risk ACS patients
11. Global study suggests need for strategies to combat unhealthy lifestyles among the poor and the rich
Post Your Comments:
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... According to ... out by the University of Toronto and the University of British Columbia suggested that ... for head injuries. The article explains that part of the reason for the controversial ...
(Date:11/27/2015)... ... November 27, 2015 , ... The rapid speed at ... people age, more care is needed, especially with Alzheimer’s, dementia and other cognitive ... being overworked. The forgotten part of this equation: 80 percent of medical care ...
(Date:11/27/2015)... ... November 27, 2015 , ... An inventor, ... to dispense prescription medications at home, so he invented the patent-pending ELECTRONIC M.D. ... dispense prescription medications. In doing so, it could help to prevent potential overdose ...
(Date:11/27/2015)... ... , ... Lizzie’s Lice Pickers just announced a special promotion that will run ... purchase of lice treatment product. In addition, customers will receive a complimentary head Check ... lice is a sure way to ruin the holidays, so we encourage all of ...
(Date:11/27/2015)... ... November 27, 2015 , ... ProSidebar: Fashion is a set of ... With ProSidebar: Fasion, video editors can easily add an informative sidebar to any FCPX ... Utilize presets featuring self-animating drop zones, lines, bars, and text with the ease ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... 26, 2015 Research and Markets ( ) ... Pacemaker Market Outlook to 2019 - Rise in Cardiac Disorders ... report to their offering. Boston ... Boston scientific and others. --> ... Biotronik, Boston scientific and others. ...
(Date:11/26/2015)... DUBLIN , November 26, 2015 /PRNewswire/ ... the addition of the "2016 Future ... Drugs of Abuse Testing Market: Supplier Shares, ... report to their offering. --> ... of the "2016 Future Horizons and ...
(Date:11/26/2015)... --> ... att använda SyMRI för att hitta optimal ... med multipel skleros (MS) eller hjärntumörmetastaser och ... för att kunna använda SyMRI Research Edition ... kan man generera flera konstrastbilder från en ...
Breaking Medicine Technology: