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Comatose locusts may help relieve migraines
Date:2/7/2008

may be an evolutionary link to what happens during migraines in people. Its possible, for example, that the brain architecture necessary for increased sensitivity also predisposes areas of some peoples brains to become over-excited, and that migraines provide a means of temporarily shutting things down, he suggests.

While migraine has been associated with this disturbance for some time, the mechanisms underlying the phenomenon are not yet well understood. And that understanding will be key to designing new migraine treatments.

We found that we could precondition the locust system to be more stress-tolerant. If the mechanisms are the same as those in humans, then similar manipulations could help to protect brain function under stressful conditions, such as those leading to migraine, says Dr. Robertson.

Something is triggering events like this, he adds. Maybe we can just bias that slightly, so it wont trigger as often, or the consequences will not be as severe.

The Queens team has two joint patent applications under way: one to manipulate cellular pathways to mitigate the effects of high temperatures on the brain, and the other to manipulate pathways for migraine therapy.


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Contact: Nancy Dorrance
nancy.dorrance@queensu.ca
613-533-2869
Queen's University
Source:Eurekalert

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