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Colorectal cancer survival advantage in MUTYH-associated polyposis
Date:11/2/2010

Stephen J. Lanspa, MD, of Creighton University, hypothesize that the cancer-causing mutations in MUTYH, as well as in the mismatch repair genes predisposing to Lynch syndrome, are the causal factors for their respective survival advantages. Furthermore, they write, "the ultimate understanding of the pathogenetic pathways elicited by these respective mutations may serve as models for studying both survival and increased virulence of hereditary and sporadic colorectal cancers."


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Contact: Kristine Crane
jncimedia@oxfordjournals.org
301-841-1285
Journal of the National Cancer Institute
Source:Eurekalert

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