Navigation Links
Colorectal cancer risks quantified
Date:4/16/2009

Although the presenting features of colorectal cancer are well known, the risks they confer are less well defined. New research published in the open access journal BMC Medicine describes the exact risks posed by eight clinical features for the development of colorectal cancer in a large group of patients.

William Hamilton led a team of researchers from the Universities of Bristol and Birmingham who studied the primary care records of 5,477 colorectal cancer patients and 38,314 controls. He said, "General practitioners (GPs) gain relatively little experience in the diagnosis of colorectal cancer because the incidence is about one per GP per year, and only a proportion of these are diagnosed in primary care. Our findings strengthen the view that rectal bleeding carries a high enough risk to warrant investigation irrespective of other symptoms. Current guidance requires persistence of bleeding for 6 weeks, or accompanying diarrhoea. In our opinion, these additional requirements are unnecessary."

The authors found that the highest risks were conferred by rectal bleeding and change in bowel habit. For men over 60 years, rectal bleeding positive predictive values (PPVs) ranged from 2.4-4.5%. For women, the figures were lower, but still in the 2-3% range. Dr Hamilton added, "Change in bowel habit is less simple: GPs contributing to the database must have been using this term very differently from the separate terms of constipation and diarrhoea, in that the PPVs for change in bowel habit were considerably higher. We cannot know what features led GPs to write change in bowel habit in the notes in preference to the specific motility symptoms however, from our results it is clear that they were identifying a riskier feature, and one that warrants investigation".

The PPVs of the other presenting features were lower, but still significant. The values for constipation, diarrhoea, abdominal pain and loss of weight were all below 1.5%, confirming that they are low risk symptoms, at any age and in either sex. However, the authors are keen to point out that these are not 'no-risk' symptoms. They say, "The high-risk symptoms of rectal bleeding and change in bowel habit were only recorded in 15.6% and 11.2% of cases, respectively. The remaining majority with only a low risk symptom could have their diagnosis expedited in a number of different ways, such as new scoring systems, new biomarkers or measurement of rectal DNA. Without one of these initiatives, or a combination of them, patients with a low risk symptom will continue to be at risk of delayed diagnosis, and possible emergency presentation".


'/>"/>

Contact: Graeme Baldwin
graeme.baldwin@biomedcentral.com
44-078-774-11853
BioMed Central
Source:Eurekalert

Related medicine news :

1. Direct Anesthetic Infusion Helps Colorectal Cancer Patients
2. The fight against colorectal cancer
3. Simple, personalized interventions improve colorectal cancer screening rates
4. Studies lend insights into colorectal cancer screening
5. Virtual colonoscopy -- a new technology for colorectal cancer screening?
6. Frequently Asked Questions When Considering a Colorectal Cancer Screening Test, From the American College of Gastroenterology
7. 18F-DG PET/CT can highly increase the detection of colorectal cancer
8. Colorectal cancer screening remains essential for elderly Americans
9. Racial and ethnic differences in colorectal cancer emphasize importance of screening
10. ASGE Applauds News of Drop in Colorectal Cancer Deaths
11. Society of Gynecologic Oncologists Provides Guidelines for Offering Genetic Risk Assessment to Women With a Personal or Family History of Breast, Ovarian, Uterine or Colorectal Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... ... blind and certified personal trainer is helping to develop a weight loss fitness plan that ... the two major problems leading the fitness industry today:, , All ... They don’t eliminate all the reasons people quit their exercise program , ...
(Date:6/25/2016)... TX (PRWEB) , ... June 25, 2016 , ... Austin ... of the American College of Mohs Surgery and to Dr. Russell Peckham for medical ... and highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery ...
(Date:6/25/2016)... ... 25, 2016 , ... First Choice Emergency Room , the largest network ... the Medical Director of its new Mesquite-Samuell Farm facility. , “We are pleased ... location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of ... recognition of their exemplary accomplishments in worksite health promotion. , The Wellness at Work ... Symposium at the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic ... many turn to unhealthy avenues, such as drug or alcohol abuse, as a coping ... released tools for healthy coping following a traumatic event. , Trauma sufferers tend to ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016 Any dentist who has made ... the current process. Many of them do not even offer ... difficulties and high laboratory costs involved. And those who ARE ... at such a high cost that the majority of today,s ... Dr. Parsa Zadeh , founder of Dental Evolutions Inc. ...
(Date:6/23/2016)... Research and Markets has announced the addition of the ... to 2022" report to their offering. ... financial data derived from varied research sources to present unique ... on the market during the next five years, including a ... markets, regional and country level analysis. The report provides a ...
(Date:6/23/2016)... MOUNTAIN VIEW, Calif. , June 23, 2016 ... 9:00 a.m. CST on Thursday, July 7, 2016 , , ... kayla.belcher@frost.com ) , , , , EXPERT PANELISTS:  ... Sciences, Nitin Naik; Senior Industry Analyst, Christi Bird; Senior Industry Analyst, ... The global pharmaceutical industry is witnessing ...
Breaking Medicine Technology: