Navigation Links
Colorectal cancer risk increases in prostate cancer patients on androgen deprivation therapy

Men taking androgen deprivation therapy (ADT) for prostate cancer may have an increased risk of colorectal cancer, according to a study published online November 10 in The Journal of the National Cancer Institute.

Androgen deprivation therapy is a widely-prescribed treatment in men with prostate cancer, although its usage for low-risk disease remains controversial, given the adverse side effects, including osteoporosis, cardiovascular disease, diabetes and obesity; the last two are risk factors for colorectal cancer.

To determine whether prostate cancer patients taking androgen deprivation therapy are at an increased risk of colon cancer, Silke Gillessen, M.D., of the Cantonal Hospital in St. Gallen, Switzerland, and colleagues, did an observational study of men with prostate cancer identified through the Surveillance, Epidemiology, and End Results (SEER) database of the National Cancer Institute. Specifically, they identified 107,859 men aged 67 years or older who were diagnosed with prostate cancer between 1993 and 2002, with follow-up through 2004. The men received the ADT either in the form of gonadotropin-releasing hormone (GnRH) agonists, or an orchiectomy.

The researchers found that after adjustment for confounding variables such as age and socio-economic status, there was a 30-40% relative increase in the rate of colorectal cancer among the men treated with ADT compared with those who were not. Furthermore, the longer the men took ADT, the greater their risk of developing colorectal cancer. However, further study would be needed to determine the risk with treatment over longer periods than could be observed in this study.

The authors write that the study results could have "important implications" for men with prostate cancer taking ADT, especially those with localized, slow-growing disease, for whom the duration of ADT is generally longer.

In an accompanying editorial, Jennifer H. Lin, Ph.D., and Edward Giovannucci, M.D., of Brigham and Women's Hospital in Boston write that the study shows that an elevated risk of colorectal cancer may be an additional consideration in the decision to use ADT, especially given the side effects and their effect on quality of life.


Contact: Kristine Crane
Journal of the National Cancer Institute

Related medicine news :

1. Statins did not reduce colorectal cancer in WHI analysis
2. Colorectal cancer survival advantage in MUTYH-associated polyposis
3. Healthy Living Can Prevent Nearly 25% of Colorectal Cancers
4. Colorectal cancer patients with gene mutation show better response to cancer agent
5. Colorectal cancer screening can be expanded by offering it during mammography visits
6. Virtual colonoscopy option could improve colorectal cancer screening rates, patient survey suggests
7. Virtual colonoscopy and teleradiology bring colorectal cancer screening to patients in rural areas
8. Type 2 diabetes and insulin use are associated with colorectal cancer in men
9. Notable racial disparities in diagnosis, treatment and outcomes of colorectal cancer
10. Lack of insurance coverage remains obstacle to wider colorectal cancer screening with CT colonography
11. Colorectal cancer screening in Canada is cost-effective
Post Your Comments:
(Date:10/13/2015)... CA (PRWEB) , ... October 13, 2015 , ... ... and workflow solutions, announced today their sponsorship of the Microsoft Dynamics AXUG, GPUG ... Nevada. AXUG Summit, GPUG Summit and NAVUG Summit are independent user conferences designed ...
(Date:10/13/2015)... (PRWEB) , ... October 13, 2015 , ... In an ... utility costs were 36 percent lower per square foot than in 2009. The Williamsport ... cost of heating and cooling has decreased by eight percent. , According to ...
(Date:10/13/2015)... ... October 13, 2015 , ... e-con Systems Inc., a leading ... See3CAM_CU40, the industry’s first RGB-IR pixel format camera with a USB 3.0 ... of e-con’s See3CAM family of UVC USB 3.0 cameras, is based on the 1/3-inch ...
(Date:10/13/2015)... ... October 13, 2015 , ... ... of Anik Singal's newly launched "Publish Academy" training course . Singal's new ... opened for enrollment today, and marketers around the Internet are weighing in with ...
(Date:10/13/2015)... ... October 13, 2015 , ... Nordic ... unique health needs of new moms. Postnatal Omega-3, which has been named ... utilizes Nordic Naturals’ exclusive, new, ultra-concentrated omega-3 oil. This breakthrough oil combines ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... 13, 2015  Vitamin Angels – a charity that ... need of nutritional support - announced its work continues ... Nations (UN). The UN,s newly established Global Goals - ... recent follow up to the Millennium Development Goals established ... The new 17 Global Goals intend to address three ...
(Date:10/13/2015)... Generational Equity , a leading mergers and acquisitions advisor ... acquisition of its client, Quality Medical Rentals ... by Meridian Biomedical, Inc. (Meridian), headquartered in Colorado.  The ... Florida . To learn more, visit ... To learn more, visit . --> ...
(Date:10/13/2015)... -- The spine division of Zimmer Biomet (NYSE and SIX: ... its portfolio of innovative clinical solutions and technologies at ... 14-17, 2015, in Chicago , Illinois.  ... "Supplemental MIS Fixation Options for LLIF" NASS ... 1 p.m. --> "Supplemental MIS Fixation Options ...
Breaking Medicine Technology: