Navigation Links
Colorado researcher discovers mechanism for changing adult cells into stem-like cells
Date:10/7/2010

orking on the roles of caspases in wound healing when Yaminaka published his initial iPSC work in mice. That got Li thinking about potential roles of caspases in iPSC generation.

"I thought maybe caspases could also induce iPS cells instead of the four transcriptional factors that Yamanaka used," he says. "If that was true, it would be very exciting."

For six months, his group tried different experiments using various caspase genes to coax human skin cells into iPS cells, but they had no success. Although caspases were not sufficient to make iPS cells, Li kept going with the idea that caspases were somehow involved.

They made their discovery when they introduced the caspase inhibitors into skin cells, which almost completely shut down the induction of iPS cells.

Caspases, Li says, appear to loosen up the built-in controls that make a cell differentiated or undifferentiated, just like a clutch allows a driver to switch gears while driving. Undifferentiated stem-like cells and differentiated cells from one person have the exact same genes. The difference between them is which genes are turned on or off.

In other words, he says, caspases could be the key to a kind of cellular reincarnationtaking a cell that, during human development, became a skin cell back to its original state to become any kind of cell.

"About twenty years ago, a scientist who was among the first to clone the caspase 3 gene named the gene Yama, the Hindu Lord of Death who was responsible for both killing a being and setting him on his way into his reincarnated life," Li said. "It is now becoming clear that caspases don't just kill, but they can change the cell's fate. They could be a mediator of epigenetic changes in multi-cellular organisms."


'/>"/>

Contact: David Kelly
david.kelly@ucdenver.edu
303-315-6374
University of Colorado Denver
Source:Eurekalert

Page: 1 2

Related medicine news :

1. University of Colorado gets federal award for Cord Blood Bank
2. University of Colorado Denver Business School study shows failure better teacher than success
3. University of Colorado joins forces with major research affiliate
4. University of Colorado joins with major research firm to partner on stem cell research
5. Mission Critical Systems and Dress for Success Denver team up to train disadvantaged Colorado women
6. University of Colorado Hospital Moving Forward with $400 Million Expansion
7. Infant and Young Child Self-Rescue(TM) Swimming Program Coming to Northern Colorado
8. Homewatch CareGivers Show in Colorado is Next for SilverStone Group's In-Home Care Team
9. Skilled Colorado Plastic Surgeon Dr. Christopher G. Williams Earns Full Board Certification
10. Educational Toy Franchise Expects Continued Growth Throughout Colorado in 2010
11. Pew Report: Colorado on Track in Providing Children with Dental Health Care They Need
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2014)... The report “Micronutrient Market by Type (Zinc, ... Non Chelated), Application Mode (Soil, Foliar, Fertigation), Crop ... to 2018” defines and segments the global agriculture ... the global value and volume for agriculture micronutrients. ... for the global agriculture micronutrients market with an ...
(Date:7/13/2014)... 13, 2014 MarketsandMarkets recently conducted ... Modeling; 3D Scanning; 3D rendering; Layout and Animation; ... (2013 - 2018)”, which analyzes and studies the ... America, Western Europe, Eastern Europe, Middle East and ... draws the competitive landscape of the 3D imaging ...
(Date:7/13/2014)... WA (PRWEB) July 13, 2014 Athletes ... longer recovery period from concussions, according to research presented ... ( AOSSM ) Annual Meeting. The research marks the ... concussion based on the known physical events that occur ... patients with a long allele in the (GT)n genotype ...
(Date:7/13/2014)... July 13, 2014 Recently, MyDressCity.com, one ... women’s special occasion outfits, has released its new range ... the new products are available at discounted prices. Worldwide ... 2014. , In the company’s online shop, there ... of them are made with great materials. MyDressCity.com’s hot ...
(Date:7/13/2014)... COPENHAGEN, July 13, 2014 A decreased ability ... cognitive impairment and Alzheimer,s disease, while examinations of ... a protein associated with Alzheimer,s, in the brain, ... reported today at the Alzheimer,s Association International Conference ... of the studies, the decreased ability to identify ...
Breaking Medicine News(10 mins):Health News:Micronutrient Market Worth $6,474.6 Million by 2018 - A Report by MarketsandMarkets 2Health News:Micronutrient Market Worth $6,474.6 Million by 2018 - A Report by MarketsandMarkets 3Health News:Micronutrient Market Worth $6,474.6 Million by 2018 - A Report by MarketsandMarkets 4Health News:3D Imaging Market Worth $9.82 Billion By 2018 - Report by MarketsandMarkets 2Health News:3D Imaging Market Worth $9.82 Billion By 2018 - Report by MarketsandMarkets 3Health News:3D Imaging Market Worth $9.82 Billion By 2018 - Report by MarketsandMarkets 4Health News:Genetic Factors May Be Responsible for Slowing Concussion Recovery in Athletes 2Health News:Cheap Elegant Quinceanera Dresses Unveiled by MyDressCity.com 2Health News:Smell and eye tests show potential to detect Alzheimer's early 2Health News:Smell and eye tests show potential to detect Alzheimer's early 3Health News:Smell and eye tests show potential to detect Alzheimer's early 4Health News:Smell and eye tests show potential to detect Alzheimer's early 5Health News:Smell and eye tests show potential to detect Alzheimer's early 6Health News:Smell and eye tests show potential to detect Alzheimer's early 7
... KR ) said today,it is recalling Private Selection Peanut ... butter in the ice cream was supplied by,Peanut Corporation of ... following names are included in this recall: City Market, ... Stores the company operates under the following names ...
... factors are just as reliable, researchers say, , , MONDAY, ... variation is associated with an increased risk for heart ... who is likely to get heart disease any more ... , There has been continuing excitement in recent years ...
... early-stage lung cancer are not seen when patients are ... January issue of Archives of Surgery , one ... deaths in the United States than any other cancer, ... surgery to remove a portion of the lungprovides the ...
... received recommended care did better, regardless of race, study ... disparities between white and black patients with early-stage lung ... to a U.S. study that included nearly 18,000 patients. ... lung (pulmonary resection) provides the best chance of a ...
... of blood pressure, other factors may be boosting survival, ... First-time heart attacks in the United States aren,t as ... a long-running study finds. , "We know that deaths ... Meyerson, director of the cardiovascular disease prevention program at ...
... specializing in healthcare services at Affiliated Computer Services, Inc. ... highest ranking in a national survey for the second ... place award for its work in the Financial Enterprise ... Top 20 Best in KLAS Awards: Software & Professional ...
Cached Medicine News:Health News:Kroger Recalls Select Ice Cream Products Due to Possible Health Risk 2Health News:Genetic Data May Not Boost Heart Disease Predictions 2Health News:Study examines racial disparities in survival among patients diagnosed with lung cancer 2Health News:Optimal Treatment Boosts Blacks' Lung Cancer Survival 2Health News:U.S. Heart Attacks Becoming Less Severe 2Health News:U.S. Heart Attacks Becoming Less Severe 3Health News:ACS is 'Best in KLAS' for Healthcare Financial Implementation Services for Second Consecutive Year 2Health News:ACS is 'Best in KLAS' for Healthcare Financial Implementation Services for Second Consecutive Year 3
(Date:7/11/2014)... 11, 2014  Rock Creek Pharmaceuticals, Inc. (NASDAQ: ... that the Food and Drug Administration ("FDA"), has notified ... RCP,s Investigational New Drug ("IND") application before granting the ... US. Dr. Chris Chapman , RCP,s ... on our IND. When we receive the agency,s official ...
(Date:7/11/2014)... July 11, 2014  Kindred Hospital Houston Northwest, ... the opening of its new outpatient wound healing ... to people with chronic, hard to heal wounds. ... lead to amputation, lower leg wounds related to ... closure, and traumatic injury wounds which are complex ...
(Date:7/11/2014)... , July 11, 2014 Research and ... of the "Immunoprotein Diagnostic Testing Market - ... highest CAGR of 6% and is expected to ... to their offering. ... diagnostic testing has been segmented according to immunoprotein ...
Breaking Medicine Technology:Rock Creek Pharmaceuticals Issues Update On US Investigational New Drug Application 2Kindred Hospital Houston Northwest, With Wound Care Specialists, Opens Outpatient Wound Healing And Hyperbaric Center 2Immunoprotein Diagnostic Testing Market - Forecasts to 2019: Expected to grow at the highest CAGR of 6% and is expected to be valued at USD 4,943.0 million 2
... . , April 30 A new study, presented at ... , found that Breast-Specific Gamma Imaging (BSGI) is highly accurate in monitoring ... , , ... has been proven in several other studies to improve breast cancer detection ...
... April 29 Warner Chilcott plc (Nasdaq: WCRX ) announced ... market opening on Friday, May 7, 2010 . , ... In addition to issuing a press release, the Company will host a ... 8:00 AM (Eastern Time) to review the results. To participate in the ...
Cached Medicine Technology:BSGI Offers Clear View of Breast Tumor Response to Neoadjuvant Chemotherapy 2Warner Chilcott Announces Earnings Release Date and Conference Call For First Quarter 2010 Financial Results 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: