Navigation Links
Colorado researcher discovers mechanism for changing adult cells into stem-like cells
Date:10/7/2010

orking on the roles of caspases in wound healing when Yaminaka published his initial iPSC work in mice. That got Li thinking about potential roles of caspases in iPSC generation.

"I thought maybe caspases could also induce iPS cells instead of the four transcriptional factors that Yamanaka used," he says. "If that was true, it would be very exciting."

For six months, his group tried different experiments using various caspase genes to coax human skin cells into iPS cells, but they had no success. Although caspases were not sufficient to make iPS cells, Li kept going with the idea that caspases were somehow involved.

They made their discovery when they introduced the caspase inhibitors into skin cells, which almost completely shut down the induction of iPS cells.

Caspases, Li says, appear to loosen up the built-in controls that make a cell differentiated or undifferentiated, just like a clutch allows a driver to switch gears while driving. Undifferentiated stem-like cells and differentiated cells from one person have the exact same genes. The difference between them is which genes are turned on or off.

In other words, he says, caspases could be the key to a kind of cellular reincarnationtaking a cell that, during human development, became a skin cell back to its original state to become any kind of cell.

"About twenty years ago, a scientist who was among the first to clone the caspase 3 gene named the gene Yama, the Hindu Lord of Death who was responsible for both killing a being and setting him on his way into his reincarnated life," Li said. "It is now becoming clear that caspases don't just kill, but they can change the cell's fate. They could be a mediator of epigenetic changes in multi-cellular organisms."


'/>"/>

Contact: David Kelly
david.kelly@ucdenver.edu
303-315-6374
University of Colorado Denver
Source:Eurekalert

Page: 1 2

Related medicine news :

1. University of Colorado gets federal award for Cord Blood Bank
2. University of Colorado Denver Business School study shows failure better teacher than success
3. University of Colorado joins forces with major research affiliate
4. University of Colorado joins with major research firm to partner on stem cell research
5. Mission Critical Systems and Dress for Success Denver team up to train disadvantaged Colorado women
6. University of Colorado Hospital Moving Forward with $400 Million Expansion
7. Infant and Young Child Self-Rescue(TM) Swimming Program Coming to Northern Colorado
8. Homewatch CareGivers Show in Colorado is Next for SilverStone Group's In-Home Care Team
9. Skilled Colorado Plastic Surgeon Dr. Christopher G. Williams Earns Full Board Certification
10. Educational Toy Franchise Expects Continued Growth Throughout Colorado in 2010
11. Pew Report: Colorado on Track in Providing Children with Dental Health Care They Need
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... The Incredible Bulk is a revolutionary method put together ... by up to 30lbs in less than 12 weeks without ... Stevenson, prompting an investigative review. , “Our Incredible Bulk ... formula that allows the body to pack on a massive ...
(Date:1/22/2015)... 23, 2015 AngelWeddingDress, the premier women’s ... maternity wedding dresses. View website of AngelWeddingDress.com ... for maternity wedding dresses online for a bridal party. ... high quality for them. Its maternity wedding dresses are ...
(Date:1/22/2015)... A new white paper by The ... in the long-term care environment as well as provides ... The paper, “The Power of Person-Centeredness in Long-Term Care: ... of the patient, resident and family experience in long-term ...
(Date:1/22/2015)... 22, 2015 For over 20 years, Dr. David ... and Vista area has treated just about every type of ... circumstances. And for those same twenty-plus years, the team at ... those injuries with the best possible doctor. With the ...
(Date:1/22/2015)... NY (PRWEB) January 22, 2015 ... of Sports Medicine flagship journal Medicine & Science ... L-Citrulline before exercise may help reduce gastrointestinal (GI) ... 1 , Participants in the double-blind, placebo-controlled ...
Breaking Medicine News(10 mins):Health News:The Incredible Bulk: Review Examining Ben Pakulski’s Brand New Bulking Muscle Building Diet Program Released 2Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3Health News:Industry Leading Chiropractor in Oceanside Joins the Doctors on Liens Network 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 3
... 17 Clarent Hospital Corporation ... 12, 2007, the Company,s Board ... cash distribution to stockholders of ... is payable on October 31, ...
... 17 The Channel Islands,Alzheimer,s Institute recently received ... be received in four payments of $30,000,each beginning ... Institute is located on the campus of,California State ... donation are at least two student research,scholarships for ...
... Explanations and Insightful Tips for Finding ... Affordable Health Insurance for Your Family, SAN ... a leading source for online,health insurance quotes and ... library of consumer resources: the,Family Health Insurance Guide. Inspired ...
... Prudence Hall,founder of The Hall Center in Santa Monica, ... health of her patients. It wasn,t until she became,immersed ... started investigating her birth control patients more carefully.,"I was ... old patients on the,pill, had hormone levels that were ...
... establishing the Dyslexia Research Laboratory at Beth Israel Deaconess ... dramatic transformation in thinking among both scientists and the ... a host of explanations offered to explain dyslexia, says ... BIDMC whose work has played a key role in ...
... food is needed, study suggests , , WEDNESDAY, Oct. 17 ... to blame, research suggests. , Scientists from the University ... dopamine, a brain chemical that helps make eating and ... more food. , "We weren,t studying obesity, per se, ...
Cached Medicine News:Health News:Channel Islands Alzheimer's Institute Receives $120,000 Donation 2Health News:Health Insurance Finders Debuts A Comprehensive Guide to Family Health Insurance 2Health News:Do Not Take the Pill! Dr. Prudence Hall Tells her Teen and Female Patients 2Health News:Do Not Take the Pill! Dr. Prudence Hall Tells her Teen and Female Patients 3Health News:BIDMC Dyslexia Research Lab celebrates 25th anniversary 2Health News:Genes Might Help Drive Overeating 2Health News:Genes Might Help Drive Overeating 3
(Date:1/23/2015)... , Jan. 23, 2015  Northwest Biotherapeutics, Inc. (NASDAQ: ... personalized immune therapies for operable and inoperable solid tumor cancers, ... at the 7 th Annual Phacilitate Immunotherapy Forum in ... presentation at Phacilitate will take place on January 26 at ...
(Date:1/23/2015)... , Jan. 23, 2015 More than a third ... quarter of those with private insurance, filled a prescription for ... a report in this week,s Morbidity and Mortality Weekly Report ... care providers to treat moderate to severe pain.  They are ...
(Date:1/23/2015)... YORK , Jan. 23, 2015 /PRNewswire/-- Harwood Feffer LLP ... board of directors of Advaxis, Inc. ("Advaxis" or the ... board has breached its fiduciary duties to shareholders. ... on an investing website reporting that Advaxis had misrepresented ...
Breaking Medicine Technology:NW Bio To Present At The 7th Annual Phacilitate Immunotherapy Forum 2NW Bio To Present At The 7th Annual Phacilitate Immunotherapy Forum 3Opioid painkillers widely prescribed among reproductive age women 2Opioid painkillers widely prescribed among reproductive age women 3Harwood Feffer LLP Announces Investigation of Advaxis, Inc. 2
... 7, 2007 - REGENERX,BIOPHARMACEUTICALS' (AMEX: RGN), www.regenerx.com ... the 2007 Association for Research in,Vision and ... May 9th to discuss TB4's ability to ... process closely,associated with inflammation that, if not ...
... TSX-V: PGA, VANCOUVER, May 07, 2007 /PRNewswire-FirstCall/ - ... results from its Phase I/II study of PAC-113, ... and active,in the treatment of oral Candida infection ... of care. Based on these results,the Company plans ...
Cached Medicine Technology:Dr. Gabriel Sosne to Present New TB4 Data at 2007 ARVO Meeting 2Dr. Gabriel Sosne to Present New TB4 Data at 2007 ARVO Meeting 3Pacgen Announces Positive Results from Phase I/II Trial of Novel,Antifungal Drug 2Pacgen Announces Positive Results from Phase I/II Trial of Novel,Antifungal Drug 3Pacgen Announces Positive Results from Phase I/II Trial of Novel,Antifungal Drug 4Pacgen Announces Positive Results from Phase I/II Trial of Novel,Antifungal Drug 5
... The Physique leads are small profile endocardial ... helix. With a lead body size of ... size of 7 F, the Physique lead ... available today. Available in both straight and ...
Used with Temporary Myocardial Heartwires....
Used with permanent pacing leads....
Suture sleeve for permanent pacing leads....
Medicine Products: