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Colonoscopy technique increases polyp detection in far reaches of right colon
Date:10/18/2010

San Antonio, Texas, October 18, 2010 Research exploring the progression of colon polyps to colorectal cancer and evaluating techniques to improve polyp detection was among the clinical science presented at the 75th Annual Scientific Meeting of the American College of Gastroenterology in San Antonio today.

The Progression to Colorectal Cancer in Flat Polyps

Precancerous growths in the colon known as sessile serrated adenomas (SSA) are found in approximately 1 percent of colonoscopy exams. A sessile serrated ademona is a premalignant flat lesion in the colon thought to lead to colorectal cancer through the serrated pathway. To understand the progression of SSAs to dysplasia, Robert M. Genta, M.D., FACG, in a study, "10,000 Sessile Serrated Polyps: Slow Progression to Low‐Grade and High‐Grade Dysplasia in a Large Nationwide Population," analyzed a large nationwide dataset of over 500,000 patient records from Caris Life Sciences, a specialized gastrointestinal pathology lab.

From among those patients who underwent colonoscopy with a biopsy of abnormal tissue, Dr. Genta and his colleagues identified approximately 41 percent who had non‐hyperplastic polyps, those which are not benign. Of this group, approximately 5 percent had sessile serrated adenomas categorized as either low or high dysplasia, reflecting the degree of cellular abnormality.

"The interval for the progression from SSA to SSA with low‐grade dysplasia can be estimated to be approximately seven years, and the further progression to high‐grade dysplasia can be estimated at an additional four years. These polyps appear to advance at a slower rate than conventional adenomas," commented Dr. Genta.

Colonoscopy Technique Increases Polyp Detection in Far Reaches of Right Colon

An endoscopic technique known as retroflexion, when used in the right side of the colon, may increase the diagnostic yield of polyps, including large adenomas (la
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Contact: Jacqueline Gaulin
mediaonly@acg.gi.org
202-255-5541
American College of Gastroenterology
Source:Eurekalert

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