Navigation Links
Colonoscopies May Not Have 'Blind Spot' After All

By Amanda Gardner
HealthDay Reporter

MONDAY, Jan. 3 (HealthDay News) -- In addition to reducing the risk of cancer on the left side of the colon, new research indicates that colonoscopies may also reduce cancer risk on the right side.

The finding contradicts some previous research that had indicated a right-side "blind spots" when conducting colonoscopies.

However, the right-side benefit shown in the new study, published in the Jan. 4 issue of the Annals of Internal Medicine, was slightly less effective than that seen on the left side.

"We didn't really have robust data proving that anything is very good at preventing right-sided cancer," said Dr. Vivek Kaul, acting chief of gastroenterology and hepatology at the University of Rochester Medical Center. "Here is a paper that suggests that risk reduction is pretty robust even in the right side. [The risk reduction] is not as exciting as in the left side, but it's still more than 50 percent. That's a little hard to ignore."

The news is "reassuring," agreed Dr. David Weinberg, chairman of medicine at Fox Chase Cancer Center in Philadelphia, who wrote an accompanying editorial on the finding.

Though no one study ever provides definitive proof, he said, "if the data from this study is in fact true, then this gives strong support for current guidelines."

The American Cancer Society recommends that normal-risk men and women be screened for colon cancer, starting at age 50. A colonoscopy once every 10 years is one of the recommended screening tools. However, there has been some debate as to whether colonoscopy -- an invasive and expensive procedure -- is truly preferable to other screening methods, such as flexible sigmoidoscopy.

Based on a review of medical records of 1,688 German patients aged 50 and over with colorectal cancer and 1,932 without, the researchers found a 77 percent reduced risk for this type of malignancy among people who'd had a colonoscopy in the past 10 years, as compared with those who had not.

The lion's share of the benefit was seen for left-sided cancers, although there was still a 50 percent reduction on the right side (only 26 percent among those aged 60 and younger).

No one knows why colonoscopy seems to be superior in detecting problems on the left side of the colon.

"There are a number of potential reasons," Weinberg said. "It may be that the biology is conspiring to make it harder. [The polyps] look different, grow differently. Also, the quality of the laxative preparation tends to be less effective than on the other side so you might be more likely to miss something."

Then there's the issue of who's doing the test, which might be key.

"Colonoscopy performed by an experienced gastroenterologist or endoscopist probably mitigates the miss rate on the right side," Kaul said. "Myself and a lot of colleagues spend a lot of time in the right colon going back and forth, back and forth. You cannot just whip the scope out from there. You've got to spend time."

Weinberg added that the number of colonoscopies a person has performed also might make a difference. "This is a very good screening mechanism against a very common cancer," he said. "It's not perfect, but it works a lot better than nothing."

Kaul agreed. "This paper adds a little more bite to the argument that, yes, colonoscopy is an invasive procedure. Yes, it is somewhat costly compared to some of the other available options. But, it probably is the best value for the money out there."

A second study in the same issue of the journal found that only advanced colorectal cancers with the normal version of the KRAS gene will benefit from targeted drugs known as anti-epidermal growth factor receptor (anti-EGFR) antibodies, such as cetuximab (Erbitux) and panitumumab (Vectibix).

A review of previously conducted trials determined that people with advanced tumors with the mutated version of the gene did not live as long as those with the "wild-type" version of the gene.

More information

The American Cancer Society has more on colonoscopy and sigmoidoscopy.

SOURCES: David Weinberg, M.D., chairman, medicine, Fox Chase Cancer Center, Philadelphia; Vivek Kaul, M.D., associate professor, medicine, and acting chief, division of gastroenterology and hepatology, University of Rochester Medical Center, Strong Memorial Hospital, Rochester, N.Y.; Jan. 4, 2011, Annals of Internal Medicine

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Tests between colonoscopies could be lifesaver for high-risk patients
2. Virtual colonoscopies help identify additional cancers outside of the colon, study suggests
3. From cholera to blindness, experts present cutting-edge research at international meeting
4. Sense of Touch Faster in Those Blind From Birth
5. Lu receives grant from Research to Prevent Blindness organization
6. Shao wins grant from Research to Prevent Blindness organization for dry eye research
7. Ingredient in red wine may prevent some blinding diseases
8. Quincy Bioscience Announces Encouraging Preliminary Results of Randomized, Double-Blind, Placebo-Controlled Memory Study
9. Tool manipulation is represented similarly in the brains of the blind and the sighted
10. California Family Raising Confident, Blind Child Sharing Successes to Change Perceptions of Blindness
11. Baden Elementary School holds VisionWalk to Fight Blindness
Post Your Comments:
Related Image:
Colonoscopies May Not Have 'Blind Spot' After All
(Date:10/10/2015)... ... ... Isabel Healthcare will participate in the Cerner Health Conference October 11-14, 2015 ... Institute of Medicine’s latest report “Improving Diagnosis in Healthcare”, Isabel Healthcare will be featuring ... and consumers to potentially reduce the chance of error. The report suggests that most ...
(Date:10/9/2015)... ... October 09, 2015 , ... The American Osteopathic Foundation ... Graduate Medical Education J. Michael Finley, DO, as the recipient of the 2015 ... his impact on graduate medical education opportunities for osteopathic residents, and his dedication ...
(Date:10/9/2015)... ... ... A new health tool that helps identify if a sore throat is ... – just in time for the cold and flu season, which the Center for ... the U.S., the real start of cold/flu season is the start of the school ...
(Date:10/9/2015)... ... October 09, 2015 , ... Dentist in Huntington Beach ... system that uses clear, plastic aligners. This alternative to braces has become wildly ... allow patients to complete treatment in privacy. Additionally, Invisalign aligners are removable, so ...
(Date:10/9/2015)... (PRWEB) , ... October 09, 2015 , ... The Asthma ... the US Centers for Disease Control and Prevention (CDC) to improve the knowledge and ... that AAFA has been awarded a project by the CDC and allows AAFA to ...
Breaking Medicine News(10 mins):
... better diagnosis and drug treatments, study says , , WEDNESDAY, ... most common form of mental retardation -- called nonsyndromic ... that may contribute to the condition, new research finds. ... occurs during development of the child and is not ...
... virus strikes healthy kids, and it affects more youngsters than ... It,s called respiratory syncytial virus (RSV), a childhood infection that,s ... and one of every 38 emergency room trips, a new ... for inpatient hospital stays for one out of every 334 ...
... is a statement by Matthew L. Myers, President, ... and President Obama today are delivering a historic ... increasing federal tobacco taxes, including a 62-cent increase ... Children,s Health Insurance Program (SCHIP). This legislation ...
... Feb. 4 , WHAT: , ... event, with members of the cast,of Broadway,s Tony Award-winning best ... February 6, 2009 , WHO: , ... compelling stories of women making,heart-healthy choices and inspiring others with ...
... seeks new ways to prevent and treat chronic diseases such ... be conducted on the benefits of certain foods in reducing ... often cited as being high in antioxidants, which have the ... within the body, reducing the risk of cancer and other ...
... Feb. 4 Erik Olson, director of chemical and food ... the following statement today in response to the introduction of ... , , "In the midst of ... Safety Modernization Act (FSMA) could not be more timely. The ...
Cached Medicine News:
(Date:10/9/2015)... , October 9, 2015 ... die sich einer Kolonoskopie im Rahmen eines ... unterziehen. Die NOCT-Studie bewertete auch die Compliance, ... --> ® ) an erwachsenen Patienten ... eines Screenings, einer beobachtenden oder einer diagnostischen ...
(Date:10/9/2015)... , October 9, 2015 ... (OTCQB: CNBX) has announced its execution of an Intellectual Property ... Liabilities Agreement with Cannabics, Inc. a Delaware Corporation, related party, ... --> --> These ... of the Company, whereby the Research and Development components ...
(Date:10/9/2015)... India , October 9, 2015 ... --> The report ... market and overall status of the ... of guidance and direction for companies ... . ...
Breaking Medicine Technology:
... PRO-DEX, INC. (Nasdaq: PDEX ) invites investors and ... fiscal 2012 first quarter financial results. (Logo:   ... be broadcast live over the internet on Wednesday, November 9, ... and may be accessed by visiting the Company,s website at ...
... VIEW, Calif., Nov. 3, 2011 VIVUS, Inc. (NASDAQ: ... were published in Obesity, the peer-reviewed journal of The ... the investigational drug Qnexa in 1,267 severely obese (BMI >/= 35 ... addition to average weight loss of 14.4% of initial body weight ...
Cached Medicine Technology:
2.5V Halogen source, fiber-optic delivery, 2.5X magnification....
Pocket-sized instrument with 2.5X magnification....
Pocket-sized instrument. All Keeler otoscopes have bright halogen illumination for clear and accurate visualization of aural canal. Lithium-ion batteries with quick recharge capability. Ring rheos...
Otoscope with 4X magnification lens, swivellable to both sides, with removable cover glass to insert external instruments. Sealed system allowing for pneumatic otoscopy. 2.5V halogen source....
Medicine Products: